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The dermal papilla cells (DPCs) of hair follicles are known to secrete paracrine factors for follicular cells. Shotgun proteomic analysis was performed to compare the expression profiles of the secretomes of human DPCs and dermal fibroblasts (DFs). In this study, the proteins secreted by DPCs and matched DFs were analyzed by 1DE/LTQ FTICR MS/MS, semi-quantitatively determined using emPAI mole percent values and then characterized using protein interaction network analysis. Among the 1,271 and 1,188 proteins identified in DFs and DPCs, respectively, 1,529 were further analyzed using the Ingenuity Pathway Analysis tool. We identified 28 DPC-specific extracellular matrix proteins including transporters (ECM1, A2M), enzymes (LOX, PON2), and peptidases (C3, C1R). The biochemically- validated DPC-specific proteins included thrombospondin 1 (THBS1), an insulin-like growth factor binding protein3 (IGFBP3), and, of particular interest, an integrin beta1 subunit (ITGB1) as a key network core protein. Using the shotgun proteomic technique and network analysis, we selected ITGB1, IGFBP3, and THBS1 as being possible hair-growth modulating protein biomarkers.

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Retroviral integration profiles : their determinants andimplications for gene therapy Kwang-il Lim pp.207-212

Systems biology of virus-host signaling network interactions Qiong Xue, Kathryn Miller-Jensen pp.213-220

Anticoagulant activities of curcumin and its derivative Dong-Chan Kim, Sae-Kwang Ku, Jong-Sup Bae pp.221-226

Translation elongation factor-1A1(eEF1A1) localizes to thespine by domain III Sun-Jung Cho, HyunSook Lee, Samikshan Dutta, Dae-Hyun Seog, Il Soo Moon pp.227-232

Affinity chromatography and capillary electrophoresis foranalysis of the yeast ribosomal proteins Miriam S. Goyder, Keith R. Willison, David R. Klug, Andrew J. deMello, Oscar Ces pp.233-238

Bacillus subtilis HmoB is a heme oxygenase with a novel structure Seonghun Park, Sarah Choi, Jungwoo Choe pp.239-241

Resveratrol and piperine enhance radiosensitivity of tumorcells Jean Kyoung Tak, Jun Ho Lee, Jeen-Woo Park pp.242-246

Smads, p38 and ERK1/2 are involved in BMP9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells Dao-jing Xu, Ying-ze Zhao, Jin Wang, Juan-wen He, Ya-guang Weng, Jin-yong Luo pp.247-252

Comparative secretome analysis of human follicular dermalpapilla cells and fibroblasts using shotgun proteomics Chong Hyun Won, Oh Sang Kwon, Yong Jung Kang, Hyeon Gyeong Yoo, Dong Hun Lee, Jin Ho Chung, Kyu Han Kim, Won Seok Park, Nok Hyun Park, Kun Cho … [et al.] pp.253-258

Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism Oluwafemi Davies, Pedro Mendes, Kieran Smallbone, Naglis Malys pp.259-264

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