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Multinucleated giant cells appear in a variety forms in different types of oral lesion. However, their nature is still not well understood. Thus, to address this issue, the immunohistochemical characteristics of inflammatory giant cells (Langhans’ giant cells in lesions of tuberculosis and foreign body giant cells in odontogenic keratocysts and squamous cell carcinomas) and tumor giant cells in central giant cell granulomas were compared with those of osteoclasts, the normal giant cell, using a panel of macrophage and osteoclast marker antibodies, such as calcitonin receptor (CT-R), c-Src, Cathepsin K (Cath-K), CD14, RANK, and c-fms. The foreign body giant cells around cholesterol clefts in inflamed odontogenic keratocysts revealed more macrophage-like characteristics than the foreign body giant cells resorbing keratin pearls in squamous cell carcinomas. As such, both cases of foreign body giant cell exhibited immunoreactivity for the macrophage markers, such as CD14, RANK, and c-fms, yet only the latter case exhibited immunoreactivity for the osteoclast markers, such as CT-R and c-Src. Moreover, both cases of foreign body giant cells were positive for TRAP activity, yet negative for Cathepsin K activity. In contrast, the other inflammatory giant cells, Langhans’ giant cells,exhibited immunoreactivity for both the macrophage and osteoclast markers, yet were negative for TRAP activity. Meanwhile, the giant cells in the central giant cell granulomas reacted positively to both the macrophage and osteoclast markers, and were also positive for TRAP activity. Accordingly, these findings suggest that the immunoprofiles of giant cells in oral lesions vary according to the nature of the lesion, despite shared osteoclast and macrophage characteristics. Furthermore, the giant cells in tumorous lesions closely associated with bony destruction revealed more osteoclastic characteristics and their enzyme components were different according to the nature of the lesion.

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Differential diagnosis of papillary papilloma verrucous papilloma, and inverted papilloma from oral squamous cell papillomas Sang Shin Lee, Hyun Ju Kim, Seong Yeon Park, Yeon Sook Kim, Suk Keun Lee pp.69-76

Immunohistochemical evaluation of multinucleated giant cells in oral lesions Jong Ho Lim, Ji Hye Lee, Hong In Shin pp.77-85

한국인의 타석증에 대한 임상병리학적 리뷰 박시원, 조영아, 신의정, 윤혜정, 홍성두, 이재일, 홍삼표 pp.87-91

Cytokeratin 8/18과 Vimentin의 분포에 따른 법랑모세포종의 발생학적 연구 김정현, 이종헌, 유태민, 송영균, 도래미, 박경주 pp.93-98

Hypoxia-induced alteration in microRNAs and predicted target mRNAs implicated in progression of oral squamous cell carcinoma Ji Hye Lee pp.99-108

Carcinoma ex pleomorphic adenoma including two carcinoma components arising in the palate Hiroyuki Kaneko, Takashi Muramatsu, Kitaro Onozawa, Hisashi Yano, Mami Owada, Hiroyuki Abe pp.109-112

Differential diagnosis of glandular odontogenic cyst versus non-odontogenic cyst in anterior maxilla Yeon Sook Kim, Eul Rak Song, Suk Keun Lee pp.113-119

대한구강악안면병리학회 약사. 1 조재오 pp.57-68

참고문헌 (28건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Thomas C, Richter GW: Sandritter’s color atlas and textbook of histopathology. 7th Ed 1984;31-32. 미소장
2 Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. 네이버 미소장
3 Generation of multinucleated giant cells in vitro by culture of human monocytes with Mycobacterium bovis BCG in combination with cytokine-containing supernatants. 네이버 미소장
4 The biological relevance of polykaryons in the immune response 네이버 미소장
5 Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. 네이버 미소장
6 Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation 네이버 미소장
7 Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor 네이버 미소장
8 Multinucleated giant cells. 네이버 미소장
9 Monocyte-derived multinucleated giant cells and sarcoidosis. 네이버 미소장
10 Athanasou NA, Wuinn J: Immunophenotypic differences between osteoclasts and macrophage polykaryons: Immunohistological distinction and implications for osteoclast ontogeny and function. J Clin Pathol 1990;43:997-1003. 미소장
11 Human tumour‐associated macrophages differentiate into osteoclastic bone‐resorbing cells 네이버 미소장
12 Monocyte-macrophage lineage of giant cell tumor of bone. Establishment of a multinucleated cell line. 네이버 미소장
13 Tiffee JC, Aifdeprte TB: Markers for macrophage and osteoclast lineages in giant cell lesions of the oral cavity. J. Oral Maxillofac Surg 1997;55:1108-1112. 미소장
14 Neale SD, Athanasou NA: Cytokine receptor profile of arthroplasty macrophages, foreign body giant cells and mature osteoclasts. Acta Orthop Scand 1999;70:452-458. 미소장
15 Boyle WJ, Simonet WS, Lacey DL: Osteoclast differentiation and activation 2003;423:337-342. 미소장
16 OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. 네이버 미소장
17 Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis: Biochem Biophys Res Commun 1998;253:395-400. 미소장
18 Functions of the M-CSF receptor on osteoclasts. 네이버 미소장
19 Macrophage activation results in bone resorption. 네이버 미소장
20 Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. 네이버 미소장
21 Haring JI, Van Dis ML: Odontogenic keratocysts:a clinical, radiographic, and histopathologic study. Oral Surg Oral Med Oral Pathol 1988;66:145-153. 미소장
22 Mineralization of connective tissue surrounding implanted devices. 네이버 미소장
23 Ballanti P, Minisola S, Pacitti MT, Scarnecchia L, Rosso R, Mazzuoli GF, Bonucci E: Tartrate-resistant acid phosphate activity as osteoclastic marker:sensitivity of cytochemical assessment and serum assay in comparison with standardized osteoclast histomorphometry. Osteoporos Int 1997;7:39-43. 미소장
24 Buhling F, Reisenauer A, Gerber A, Kruger S, Weber E, Bromme D, Roessner A, Ansorge S, Welte T, Rocken C: Cathepsin K--a marker of macrophage differentiation? J Pathol 2001;195:375-82. 미소장
25 The nature of giant cell tumor of bone. 네이버 미소장
26 The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. 네이버 미소장
27 Cellular mechanisms of osteoclast formation and lacunar resorption in giant cell granuloma of the jaw 네이버 미소장
28 Markers for macrophage and osteoclast lineages in giant cell lesions of the oral cavity 네이버 미소장

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