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The DJ-1 superfamily (DJ-1/ThiJ/PfpI superfamily) is distributed across all three kingdoms of life. These pro-teins are involved in a highly diverse range of cellular functions, including chaperone and protease activity. DJ-1 proteins usually form dimers or hexamers in vivo and show at least four different binding orientations via distinct interface patches. Abnormal oligomerization of human DJ-1 is related to neurodegenerative disorders including Parkinson’s disease, suggesting important functional roles of quaternary structures. However, the quaternary structures of the DJ-1 superfamily have not been extensively studied. Here, we focus on the diverse oligomerization modes among the DJ-1 superfamily proteins and investigate the functional roles of quaternary structures both computationally and experimentally. The oligomerization modes are classified into 4 types (DJ-1, YhbO, Hsp, and YDR types) depending on the distinct interface patches (I-IV) upon dimerization. A unique, rotated interface via patch I is reported, which may potentially be related to higher order oligomerization. In general, the groups based on sequence similarity are consistent with the quaternary structural classes, but their biochemical functions cannot be directly inferred using sequence information alone. The observed phyletic pattern suggests the dynamic nature of quaternary structures in the course of evolution. The amino acid residues at the interfaces tend to show lower mutation rates than those of non-interfacial surfaces.

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기사명 저자명 페이지 원문 목차
Molecular links between mitochondrial dysfunctions and schizophrenia Cana Park, Sang Ki Park pp.105-110

Identification and characterization of a noncoding RNA at the mouse Pcna locus Ji-Yeon Lee, Abdul Aziz Khan, Hyehyun Min, Xinnan Wang, Myoung Hee Kim pp.111-116

Activation of rice Yellow Stripe1-Like 16(OsYSL16) enhances iron efficiency Sichul Lee, Nayeon Ryoo, Jong-Seong Jeon, Mary Lou Guerinot, Gynheung An pp.117-126

Expression profiling after induction of demethylation in MCF-7 breast cancer cells identifies involvement of TNF-α mediated cancer pathways Ju Hee Kim, Seongeun Kang, Tae Woo Kim, Lihong Yin, Ran Liu, Sun Jung Kim pp.127-133

Overexpression of Arabidopsis dehydration-responsive element-binding protein 2C confers tolerance to oxidative stress Jung Eun Hwang, Chan Ju Lim, Huan Chen, Jihyun Je, Chieun Song, Chae Oh Lim pp.135-140

Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling Sun Joo Park, You Jin Jeon pp.141-149

Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity Sung Hee Hwang, Tae-Joon Shin, Sun-Hye Choi, Hee-Jung Cho, Byung-Hwan Lee, Mi Kyung Pyo, Jun-Ho Lee, Jiyeon Kang, Hyeon-Joong Kim, Chan-Woo Park … [et al.] pp.151-162

Dissection of the dimerization modes in the DJ-1 superfamily Hoi Jong Jung, Sangok Kim, Yun Jae Kim, Min-Kyu Kim, Sung Gyun Kang, Jung-Hyun Lee, Wankyu Kim, Sun-Shin Cha pp.163-171

The effects of rosiglitazone on osteoblastic differentiation, osteoclast formation and bone resorption Eui-Sic Cho, Myoung-Kyun Kim, Young-Ok Son, Keun-Soo Lee, Seung-Moon Park, Jeong-Chae Lee pp.173-181

A MAP kinase pathway is implicated in the pseudohyphal induction by hydrogen peroxide in Candica albicans Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim, Wonja Choi pp.183-193

pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases In-Young Hwang, Jae-Seok Roe, Ja-Hwan Seol, Hwa-Ryeon Kim, Eun-Jung Cho, Hong-Duk Youn pp.195-201

Moesin is a biomarker for the assessment of genotoxic carcinogens in mouse lymphoma Yoen Jung Lee, In-Kwon Choi, Yhun Yhong Sheen, Sue Nie Park, Ho Jeong Kwon pp.203-210

A mutational study of Cnu reveals attractive forces between Cnu and H-NS Sang Hoon Yun, Sang Chun Ji, Heung Jin Jeon, Xun Wang, Younghoon Lee, Byong-Seok Choi, Heon M. Lim pp.211-216

참고문헌 (42건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Abdallah, J., Kern, R., Malki, A., Eckey, V., and Richarme, G. (2006). Cloning, expression, and purification of the general stress protein YhbO from Escherichia coli. Protein Expr. Purif. 47, 455-460. 미소장
2 YhbO protects cells against multiple stresses. 네이버 미소장
3 Bandyopadhyay, S., and Cookson, M.R. (2004). Evolutionary and functional relationships within the DJ1 superfamily. BMC Evol. Biol. 4, 6. 미소장
4 Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism 네이버 미소장
5 Crystallographic water sites from a theoretical perspective. 네이버 미소장
6 The Parkinson's Disease Protein DJ-1 Is Neuroprotective Due to Cysteine-Sulfinic Acid-Driven Mitochondrial Localization 네이버 미소장
7 Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. 네이버 미소장
8 Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage 네이버 미소장
9 Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution. 네이버 미소장
10 Features and development of Coot 네이버 미소장
11 Structure of the stress response protein DR1199 from Deinococcus radiodurans: a member of the DJ-1 superfamily. 네이버 미소장
12 Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. 네이버 미소장
13 Crystal Structure of the YDR533c S. cerevisiae Protein, a Class II Member of the Hsp31 Family 네이버 미소장
14 Purification and Characterization of Two Functional Forms of Intracellular Protease PfpI from the Hyperthermophilic Archaeon Pyrococcus furiosus. 네이버 미소장
15 The C‐terminal domain of HPII catalase is a member of the type I glutamine amidotransferase superfamily 네이버 미소장
16 Interaction of DJ-1 with Daxx Inhibits Apoptosis Signal-Regulating Kinase 1 Activity and Cell Death 네이버 미소장
17 DJ-1, a novel regulator of the tumor suppressor PTEN 네이버 미소장
18 Kim, W.K., Henschel, A., Winter, C., and Schroeder, M. (2006). The many faces of protein-protein interactions: a compendium of interface geometry. PLoS Comput. Biol. 2, e124. 미소장
19 Larkin, M.A., Blackshields, G., Brown, N.P., Chenna, R., McGettigan, P.A., McWilliam, H., Valentin, F., Wallace, I.M., Wilm, A., Lopez, R., et al. (2007). Clustal W and Clustal X version 2.0Bioinformatics 23, 2947-2948. 미소장
20 Laskowski, R.A., Rullmannn, J.A., MacArthur, M.W., Kaptein, R., and Thornton, J.M. (1996). AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J. Biomol. NMR 8, 477-486. 미소장
21 Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. 네이버 미소장
22 Li, Y.H., Wang, Y.Y., Zhong, S., Rong, Z.L., Ren, Y.M., Li, Z.Y., Zhang, S.P., Chang, Z.J., and Liu, L. (2009). Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling. Mol. Cells 27, 39-45. 미소장
23 A new evolutionary paradigm for the Parkinson disease gene DJ-1. 네이버 미소장
24 Cloning and characterization of the thiD/J gene of Escherichia coli encoding a thiamin-synthesizing bifunctional enzyme, hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase. 네이버 미소장
25 Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. 네이버 미소장
26 Chaperone Hsp31 contributes to acid resistance in stationary-phase Escherichia coli. 네이버 미소장
27 Pathological properties of the Parkinson’s disease-associated protein DJ-1 in α-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick’s disease 네이버 미소장
28 T-Coffee: A novel method for fast and accurate multiple sequence alignment. 네이버 미소장
29 The alpha/beta hydrolase fold. 네이버 미소장
30 Processing of X-ray diffraction data collected in oscillation mode. 네이버 미소장
31 Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues 네이버 미소장
32 Quigley, P.M., Korotkov, K., Baneyx, F., and Hol, W.G. (2003). The1.6-A crystal structure of the class of chaperones represented byEscherichia coli Hsp31 reveals a putative catalytic triad. Proc.Natl. Acad. Sci. USA 100, 3137-3142. 미소장
33 Hsp31, the Escherichia coli yedU gene product, is a molecular chaperone whose activity is inhibited by ATP at high temperatures. 네이버 미소장
34 DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. 네이버 미소장
35 MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0 네이버 미소장
36 Molecular replacement with MOLREP 네이버 미소장
37 Wei, Y., Ringe, D., Wilson, M.A., and Ondrechen, M.J. (2007). Identification of functional subclasses in the DJ-1 superfamily proteins. PLoS Comput. Biol. 3, e10. 미소장
38 Wilson, M.A., St Amour, C.V., Collins, J.L., Ringe, D., and Petsko, G.A. (2004). The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/ PfpI superfamily. Proc. Natl. Acad. Sci. USA 101, 1531-1536. 미소장
39 The Atomic Resolution Crystal Structure of the YajL (ThiJ) Protein from Escherichia coli: A Close Prokaryotic Homologue of the Parkinsonism-associated Protein DJ-1 네이버 미소장
40 SCOPPI: a structural classification of protein–protein interfaces 네이버 미소장
41 Cysteine pKa depression by a protonated glutamic acid in human DJ-1. 네이버 미소장
42 Inactivation of Drosophila DJ-1 Leads to Impairments of Oxidative Stress Response and Phosphatidylinositol 3-Kinase/Akt Signaling 네이버 미소장

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