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국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

초록보기

This experiment was carried out in order to separate bovine colostral whey protein from Imsil province and to test the effect of immunological activity on RAW 264.7 cells. The colostral whey protein contained TGF-β 7, 475 pg/g in total. We first tested the effect of the colostral whey protein on the proliferation of RAW 264.7 cells and it demonstrated cytotoxicity at concentrations greater than 20 mg/mL. Therefore, the immunological activities of colostral whey protein were investigated in maximum concentration of 10 mg/mL on LPS-induced RAW 264.7 cells. Results indicated that colostral whey protein inhibited the LPS-induced nitric oxide (NO) production in a dose-dependent manner. The colostral whey protein also suppressed the productions of proinflammatory cytokines (TNF-α, IL-1β, IL-6) in a dose-dependent manner. In addition to the immunological activity, colostral whey protein led to the expression of heme oxygenase-1 (HO-1) in RAW 264.7 cells.

In conclusion, colostral whey protein containing TGF-β inhibited the production of NO, TNF-α, IL-1β, and IL-6 via expression of HO-1.

권호기사

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참고문헌 (26건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Ahn, J. H. and Park J. K. (2010) Effect of supplementation of fermented colostrum on growth and occurrence of diarrhea in holstein calves. J. Ani. Sci. Technol. 52, 281-286. 미소장
2 Bovine colostrum inhibits nuclear factor κB–mediated proinflammatory cytokine expression in intestinal epithelial cells 네이버 미소장
3 Bovine Colostrum Prevents Bacterial Translocation in an Intestinal Ischemia/Reperfusion-Injured Rat Model 소장
4 Elfstrand, L., Lindmak-Mnsson, H., Paulsson, M., Nyberg, L., and kesson, B. (2002) Immunoglobulins, growth factors and growth hormone in bovine colostrums and the effects of processing. Int. Dairy J. 12, 879-887. 미소장
5 Jeon, S. K. (2001) Characterization of TGF-β present in human and bovine colostrum. M.D. Thesis, Kangwon Univ., Chuncheon, Korea. 미소장
6 Jeong, I. Y., Jin, C. H., Pack, Y. D., Lee, H. J., Choi, D. S., Byun, M. W., and Kim, Y. J. (2008) Anti-inflammatory activity of an ethanol extract of Caesalpinia sappan L. in LPSinduced RAW 264.7 cells. J. Food Sci. Nutr. 13, 253-258. 미소장
7 Jin, M., Suh, S. J., Yang, J. H., Lu, Y., Kim, S. J., Kwon, S., Jo, T. H., Kim, J. W., Park, Y. I., Ahn, G. W., Lee, C. K., Kim, C. H., Son, J. K., Son, K. H., and Chang, H. W. (2010) Antiinflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW 264.7 cells via NF-κB and ERK1/2 inactivation. Food Chem. Toxicol. 48, 3073-3079. 미소장
8 Kang, S. H. (2007) Milk-derived growth factors as neutraceuticals. Korean J. Dairy Sci. Technol. 25, 27-31. 미소장
9 Combined effects of bovine colostrum and glutamine in diclofenac-induced bacterial translocation in rat 네이버 미소장
10 Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice. 네이버 미소장
11 Biotechnology Journal 10/2010 네이버 미소장
12 Liblau, R. S., Singer, S. M., and McDevitt, H. O. (1995) Th1 and Th2 cells in the pathogenesis of organ-specific autoimmune disease. Immunol. Today 16, 34-38. 미소장
13 Involvement of TGF-β in Inhibitory Effects of Negatively Charged Liposomes on Nitric Oxide Production by Macrophages Stimulated with LPS 네이버 미소장
14 TGF-β1 enhances degradation of IFN-γ-induced iNOS protein via proteasomes in RAW 264.7 cells 네이버 미소장
15 Nam, M. S., Bae, H. C., Kim, P. H., Kim, W. S., and Goh, J. S. (2002) Purification of TGF-β1 from bovine colostrums. Korean J. Food Sci. Ani. Resour. 22, 343-347. 미소장
16 Growth factors and antimicrobial factors of bovine colostrum 네이버 미소장
17 Park, J. D., Son, D. H., Jeong, K. S. (2003) Stability of immunoglobulin G(IgG) by heat treatment. Korean J. Food Preserv. 10, 236-240. 미소장
18 Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. 네이버 미소장
19 Rodriguez, C., Castro, N., Capote, J., Morales-delaNuez, A., Moreno-Indias, I., Sanchez-Macias, D., and Arguello, A. (2008) Effect of colostrum immunoglobulin concentration on immunity in Majorera goat kids. J. Dairy Sci. 92, 1696-1701. 미소장
20 Stimulation by colostrum or mature milk of gastrointestinal tissue development in newborn pigs. 네이버 미소장
21 Anti-inflammatory effect of ethyl acetate extract from Cissus quadrangularis Linn may be involved with induction of heme oxygenase-1 and suppression of NF-κB activation. 네이버 미소장
22 A role for transforming growth factor-beta 1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus. 네이버 미소장
23 Sugisawa, H., Itou, T., and Sakai, T. (2001) Promoting effect of colostrums on the phagocytic activity of bovine polymorphonuclear leukocytes in vitro. Biol. Neonate 79, 140-144. 미소장
24 Preparation from bovine colostrum of a fraction rich in latent transforming growth factor-β2 and cleared of most allergenic proteins by one-step Cibacron Blue chromatography 네이버 미소장
25 Colostrum and its benefits: a review 네이버 미소장
26 Antimicrobial Activities of Lactoferrin and its Hydrolysate Obtained from the Colostrum of Hanwoo and Holstein Cattle 소장