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Background:Performance of antibody screening and identification tests before blood transfusion is important because the unexpected presence of red cell antibodies may cause hemolytic transfusion reactions. Many patients with malignancy undergo transfusion in order to overcome pancytopenia due to disease itself or chemotherapy. We investigated the type distribution of unexpected red cell antibodies in cancer patients and compared our results with those of other institutions. Methods:From January 2008 to June 2011, 30,989 serum samples were screened using a LISS/Coombs card and ID-DiaCell I, II (DiaMed AG, Morat, Switzerland). Data-Cyte Plus Reagent Red Blood Cells (Medion Diagnostics, Düdingen, Switzerland) were used in performance of antibody identification tests. Results:Out of 30,989 serum samples, 180 cases (0.58%) showed screening-positive results, and unexpected antibodies were identified in 72 cases. The type of unexpected antibody observed most often in cancer patients was a member of the Rh antibody group, anti-E in 17 cases (29.8%), followed by anti-Lea in five cases (8.8%) and anti-e in three cases (5.3%). While Rh group antibodies were observed in the colon cancer group, non-Rh group antibodies were observed in the rectal cancer group. And, in the genitourinary cancer group, Lewis group antibodies were more frequently detected than others. Conclusion:Findings from our study demonstrated a type distribution of unexpected red cell antibodies that was similar to those reported in previous studies. Compared with non-cancerous patients, no difference in type distribution of unexpected red cell antibodies was observed in cancer patients. Some antibodies were frequently observed in certain cancer groups. Further comprehensive research on unexpected antibodies based on location or histologic type of cancer is needed.

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한국인 정상 ABO 및 아형의 ABO 대립유전자의 전체염기서열분석 원은정, 박건, 조덕, 임아현, 권소영, 송혜림, 권순석, 신명근, 조남선, 양동욱 pp.1-12

Evaluation of RF300 for leukoreduction of red blood cells So-Yong Kwon, Nam-Sun Cho, Sun Nyeo Song, Ju Yeon Lee, A Hyun Lim, Hyeon Mi Lee, Yeong Cheon Ji, Chang Sik Seo, Yun Hui Park pp.13-19

저장기간에 따른 전혈 및 적혈구 농축액내의 Proteasome 농도변화 김유경, 서장수 pp.20-27

혈소판성분채집세트내 잔여혈액에서 자연살생세포의 체외 증폭 신동준, 조덕, 장윤영, 박지윤, 김주선, 김상기, 이제중, 장민중, 신명근, 양동욱 pp.28-37

헌혈혈액 혈액형검사 외부 숙련도조사 결과보고, 2011 임영애, 차영주, 김진규, 이미남, 신지연 pp.38-47

부산대학교병원에서 시행된 혈전혈소판감소자반증-용혈요독증후군 혈장교환술, 2003~2011 신경화, 이현지, 김신영, 장철훈, 박기형, 이은엽, 손한철, 김형회 pp.48-57

악성종양 환자에서 동정된 적혈구 비예기항체의 형별 분포 윤창은, 이진경, 홍영준, 홍석일, 윤보유, 조희승, 장윤환 pp.58-67

고농도 항체를 가지는 후천성 혈우병에서 혈장교환술을 이용하여 치료한 1예 김유경, 서장수 pp.68-71

면역성 혈소판감소성 자반증 환자에서 Anti-D 면역글로불린 투여 후 발생한 용혈성 빈혈 1예 정보경, 김장수, 윤승규, 고선영, 조치현, 임채승 pp.72-77

A case of immune hemolytic anemia due to autoantibodies against C and e antigens in a patient with paroxysmal nocturnal hemoglobinuria and myelodysplastic syndrome Mi-Jung Park, Yiel-Hea Seo, Pil-Whan Park, Kyung-Hee Kim, Soon-Ho Park, Ji-Hun Jeong, Jae-Hoon Lee, Jun-Shik Hong, Jeong-Yeal Ahn pp.78-83

참고문헌 (12건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 TRANSFUSION MEDICINE 네이버 미소장
2 Unexpected Antibody Positivity with the Use of the LISS/Coombs Gel Test 소장
3 The Frequency and Distribution of Unexpected Antibodies in Surgical Patients at Chonbuk National University Hospital 네이버 미소장
4 The Frequency and Distribution of Unexpected Antibodies in Transfusion Candidates with the Use of the Ortho BioVue System: Recent Four Year Experience 소장
5 The Frequency Unexpected Antibodies at Kyungpook National University Hospital 네이버 미소장
6 The Frequency and Distribution of Unexpected Red Cell Antibodies at National Cancer Center 소장
7 Clinical predictors of alloimmunization after red blood cell transfusion 네이버 미소장
8 Itzkowitz SH. Blood group-related carbohydrate antigen expression in malignant and premalignant colonic neoplasms. J Cell Biochem Suppl 1992;16G:97-101 미소장
9 Sasagawa T, Inoue M, Shimizu C, Shimizu H, Saito J, Ueda G, et al. Expression of blood group antigens A, B, H, Lewis a, Lewis b, in malignant lesions of the uterine cervix. Nihon Sanka Fujinka Gakkai Zasshi 1988;40:345-52 미소장
10 Primary gastrointestinal diffuse large B cell lymphoma presenting with cold agglutinin disease. 네이버 미소장
11 IMMUNOHEMATOLOGY: The characterization and classification of concurrent blood group antibodies 네이버 미소장
12 Alloimmune response after additional red blood cell antigen challenge in immunized hematooncology patients. 네이버 미소장

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