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Background: Necrotizing fasciitis (NF) is an infrequent but potentially lethal infection characterized by rapid progressive destruction of fascia and fat, concomitant systemic toxicity, and high fatality. In spite of the clinical significance of NF, only limited data is available regarding the clinical characteristics of patients with NF in Korea. Materials and Methods: We retrospectively reviewed the medical records of patients who had been diagnosed as community-acquired NF in 9 centers of the Republic of Korea between January 2000 and November 2010. Results: During the study period, a total of 103 patients had a community-acquired NF. Of sixty six cases with causative microorganisms identified, the majority (55, 83.3%) had monomicrobial infections. Whereas streptococci were the most common cause of NF in patients without underlying diseases (16/24, 66.7%), variable organisms, such as staphylococci, streptococci, Enterobacteriaceae , and non-fermentative Gram-negative bacilli were causative organisms of NF in patients with underlying diseases. The majority of patients with NF caused by Vibrio vulnificus or Aeromonas hydrophila (7/9, 77.8%) had liver cirrhosis or alcoholism. Surgery to counteract NF was performed in 60.2% of patients with NF (62/102), and mean time to surgery was 3 days. In-hospital mortality was observed in 21 of 99 patients with available data (21.2%). In multivariate analysis, the presence of solid tumors (adjusted OR [aOR]=63.88, 95% CI=2.58-1580.61, P=0.011), shock (aOR= 24.19, 95% CI=2.00-292.19, P=0.012), bacteremia (aOR=87.53, 95% CI= 3.99-1921.46, P=0.005), and Gram-negative bacilli infections (aOR=437.11, 95% CI=4.67-40956.82, P=0.009) were associated with in-hospital mortality. Conclusions: Streptococci were predominant causative organisms of communityacquired NF in patients without underlying diseases. However, in patients with underlying diseases, variable organisms such as staphylococci, streptococci, Enterobacteriaceae , or non-fermentative Gram-negative bacilli were isolated. NF caused by V. vulnificus or A. hydrophila occurred frequently in patients with liver cirrhosis or alcoholism. Key Words: Necrotizing fasciitis

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참고문헌 (15건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Necrotizing soft tissue infections 네이버 미소장
2 Diagnosis and management of necrotising fasciitis: a multiparametric approach 네이버 미소장
3 Necrotizing Soft-Tissue Infection: Diagnosis and Management 네이버 미소장
4 Necrotising fasciitis of upper and lower limb: A systematic review 네이버 미소장
5 The diagnosis of necrotizing fasciitis 네이버 미소장
6 Necrotizing Fasciitis: Current Concepts and Review of the Literature 네이버 미소장
7 Practice Guidelines for the Diagnosis and Management of Skin and Soft-Tissue Infections 네이버 미소장
8 Statistics Korea. The Korean Standard Classification of Diseases and Causes of Death. Availiable at: http://kostat.go.kr/ kssc/main/MainAction.do?method=sub&catgrp=kssc&cati d1=kssc03. Accessed 23 January 2012. 미소장
9 Characteristics of necrotizing fasciitis in three university hospitals in Korea 소장
10 Marine bacteria as a leading cause of necrotizing fasciitis in coastal areas of South Korea 네이버 미소장
11 Vinh DC.,Embil JM. (2005). Rapidly progressive soft tissue infections. Lancet Infect Dis ,5,501-513. 미소장
12 Clinical significance of spontaneous Aeromonas bacterial peritonitis in cirrhotic patients: a matched case-control study. 네이버 미소장
13 Diagnosis and management of necrotizing fasciitis. 네이버 미소장
14 Treatment of complicated skin and soft tissue infections. 네이버 미소장
15 NECROTIZING FASCIITIS 네이버 미소장