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국회도서관 홈으로 정보검색 소장정보 검색

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Background: It is important to differentiate Graves’ disease from that of painless thyroiditis in patients with thyrotoxicosis. In this study, we evaluated the usefulness of total T3 to free T4 ratio in making a differential diagnosis between Graves’ disease and painless thyroiditis.

Methods: We reviewed medical records of thyrotoxic patients, who had been diagnosed with Graves’ disease or painless thyroiditis,from October 2009 to July 2011. We assessed clinical characteristics, serum levels of total T3, free T4, thyroid stimulating hormone,thyrotropin-binding inhibitory immunoglobulin, and findings of 99mTechnetium thyroid scan. We analyzed the total T3/free T4 ratios between Graves’ disease and painless thyroiditis patients.

Results: A total of 76 untreated thyrotoxic patients “49 Graves’ disease and 27 painless thyroiditis” were examined. The total T3,free T4 levels and the total T3/free T4 ratios were significantly higher in patients with Graves’ disease than in those with painless thyroiditis (P < 0.001). In the total T3/free T4 ratio > 73, the possibility of Graves’ disease was significantly higher than in painless thyroiditis (sensitivity, 75.5%; specificity, 70.3%). The sensitivity and specificity of the total T3/free T4 ratio in patients with free T4< 3.6 ng/dL have been increased (sensitivity, 100%; specificity, 71.4%).

Conclusion: The total T3/free T4 ratios was useful for making a differential diagnosis between Graves’ disease and painless thyroiditis.

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참고문헌 (15건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Lymphocytic Thyroiditis With Spontaneously Resolving Hyperthyroidism (Silent Thyroiditis) 네이버 미소장
2 Low incidence of painless thyroiditis in the Philadelphia area. 네이버 미소장
3 Silent (Painless) Thyroiditis 네이버 미소장
4 Cooper DS: Treatment of thyrotoxicosis. In: Braverman LR, Utiger RD. Werner and Ingbar’s the Thyroid: A Fundamental and Clinical Text. 9th ed. pp665-694, Philadelphia, JB Lippincott Co., 2004 미소장
5 Second Generation Assay for Thyrotropin Receptor Antibodies Has Superior Diagnostic Sensitivity for Graves' Disease 네이버 미소장
6 Sayama N, Yoshida K, Mori K, Fukazawa H, Hori H, Nakazato N, Tani J, Nakagawa Y, Ito S: Measurement of red blood cell zinc concentration with Zn-test kit: discrimination between hyperthyroid Graves’ disease and transient thyrotoxicosis. Endocr J 45:767-772, 1998 미소장
7 Schott M, Feldkamp J, Bathan C, Fritzen R, Scherbaum WA, Seissler J:Detecting TSH-receptor antibodies with the recombinant TBII assay: technical and clinical evaluation. Horm Metab Res 32:429-435, 2000 미소장
8 Frequency and characteristics of TBII‐seronegative patients in a population with untreated Graves’ hyperthyroidism: a prospective study 네이버 미소장
9 The occurrence of thyrotropin binding-inhibiting immunoglobulins and thyroid-stimulating antibodies in patients with silent thyroiditis. 네이버 미소장
10 Amino N, Yabu Y, Miki T, Morimoto S, Kumahara Y, Mori H, Iwatani Y, Nishi K, Nakatani K, Miyai K: Serum ratio of triiodothyronine to thyroxine, and thyroxine-binding globulin and calcitonin concentrations in Graves’ disease and destruction-induced thyrotoxicosis. J Clin Endocrinol Metab 53:113-116, 1981 미소장
11 Lower serum free thyroxine (T4) levels in painless thyroiditis compared with Graves' disease despite similar serum total T4 levels. 네이버 미소장
12 Simple and practical parameters for differentiation between destruction-induced thyrotoxicosis and Graves' thyrotoxicosis. 네이버 미소장
13 Yanagisawa T, Sato K, Kato Y, Shimizu S, Takano K: Rapid differential diagnosis of Graves’ disease and painless thyroiditis using total T3/T4 ratio, TSH, and total alkaline phosphatase activity. Endocr J 52:29-36, 2005 미소장
14 Ratio of Serum Free Triiodothyronine to Free Thyroxine in Graves' Hyperthyroidism and Thyrotoxicosis Caused by Painless Thyroiditis 네이버 미소장
15 Quantitative measurement of thyroid blood flow for differentiation of painless thyroiditis from Graves' disease. 네이버 미소장