본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

 The structures of the intact synaptosomal plasma membrane vesicles (SPMVs) isolated from bovine cerebral cortexs, and the outer and the inner monolayer separately, were evaluated with 1,6-diphenyl-1,3,5-hexatriene (DPH) and 1,3-di(1-pyrenyl)propane (Py-3-Py) as fluorescent reporters and trinitro-phenyl groups as quenching agents. The methanol increased bulk rotational and lateral mobilities of SPMVs lipid bilayers. The methanol increased the rotational and lateral mobilities of the outer monolayers more than of the inner monolayers. n-(9-Anthroyloxy)stearic acid (n-AS) were used to evaluate the effect of the methanol on the rotational mobility at the 16, 12, 9, 6, and 2 position of aliphatic chains present in phospholipids of the SPMVs outer monolayers. The methanol decreased the anisotropy of the 16-(9-anthroyloxy)palmitic acid (16-AP), 12-(9-anthroyloxy)stearic acid (12-AS), 9-(9-anthroyloxy)stearic acid (9-AS), and 6-(9-anthroyloxy)stearic acid (6-AS) in the SPMVs outer monolayer but it increased the anisotropy of 2-(9-anthroyloxy)stearic acid (2-AS) in the monolayers. The magnitude of the increased rotational mobility by the methanol was in the order at the position of 16, 12, 9, and 6 of aliphatic chains in phospholipids of the outer monolayers. Furthermore, the methanol increased annular lipid fluidity and also caused membrane proteins to cluster. The important finding is that was far greater increase by methanol in annular lipid fluidity than increase in lateral and rotational mobilities by the methanol. Methanol alters the stereo or dynamics of the proteins in the lipid bilayers by combining with lipids, especially with the annular lipids. In conclusion, the present data suggest that methanol, in additions to its direct interaction with proteins, concurrently interacts with membrane lipids, fluidizing the membrane, and thus inducing conformational changes of proteins known to be intimately associated with membranes lipids.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Immunostimulatory effects of β-glucan purified from Paenibacillus polymyxa JB115 on mouse splenocytes Ji-Mi Kim, Hong-Gu Joo pp.225-230

Effects of single treatment of anti-dementia drugs on sleep-wake patterns in rats Ji-Young Jung, Mootaek Roh, Kyung-Kyun Ko, Hwan-Soo Jang, Seong-Ryong Lee, Jeoung-Hee Ha, Il-Sung Jang, Ho-Won Lee, Maan-Gee Lee pp.231-236

Anovel carbamoyloxy arylalkanoyl arylpiperazine compound(SKL-NP) inhibits hyperpolarization-activated cyclic nucleotide-gated(HCN) channel currents in rat dorsal root ganglion neurons Gehoon Chung, Tae-hyung Kim, Hyewon Shin, Eunhee Chae, Hanju Yi, Hongsik Moon, Hyun Jin Kim, Joong Soo Kim, Sung Jun Jung, Seog Bae Oh pp.237-241
Morphologic evidence of anti-tumor specificity of T cells activated by denritic cells derived from peripheral blood mononuclear cells of thyroid cancer patients Dae-Heui Lee pp.243-247

Thesafety and pharmacokinetics of cyanidin-3-glucoside after 2-week administration of black bean seed coat extract in healthy subjects Sangil Jeon, Seunghoon Han, Jongtae Lee, Taegon Hong, Dong-Seok Yim pp.249-253

Theeffect of methanol on the structural parameters of neuronal membrane lipid bilayers Hyung-Jin Joo, Shin-Ho Ahn, Hang-Rae Lee, Sung-Woo Jung, Chang-Won Choi, Min-Seok Kim, Moon-Kyoung Bae, In-Kyo Chung, Soo-Kyoung Bae, Hye-Ock Jang … [et al.] pp.255-264

Increased HoxB4 inhibits apoptotic cell death in pro-B cells Sung-Won Park, Kyung-Jong Won, Yong-Soo Lee, Hye Sun Kim, Yu-Kyung Kim, Hyeon-Woo Lee, Bokyung Kim, Byeong Han Lee, Jin-Hoi Kim, Dong-Ku Kim pp.265-271

Asimple dosing scheme for intravenous busulfan based on retrospective population pharmacokinetic analysis in Korean patients Sangmin Choe, Gayeong Kim, Hyeong-Seok Lim, Sang-Heon Cho, Jong-Lyul Ghim, Jin Ah Jung, Un-Jib Kim, Gyujeong Noh, Kyun-Seop Bae, Dongho Lee pp.273-279

Comparison of neurite outgrowth induced by erythropoietin(EPO) and carbamylated erythropoietin(CEPO) in hippocampal neural progenitor cells Dong Hoon Oh, In Young Lee, Miyeon Choi, Seok Hyeon Kim, Hyeon Son pp.281-285

Dipeptides inhibit melanin synthesis in Mel-Ab cells through down-regulation of yyrosinase Hyun-e Lee, Eun-Hyun Kim, Hye-Ryung Choi, Uy Dong Sohn, Hye-Young Yun, Kwang Jin Baek, Nyoun Soo Kwon, Kyoung-Chan Park, Dong-Seok Kim pp.287-291

참고문헌 (56건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Effects of low concentrations of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes. 네이버 미소장
2 Drug Tolerance in Biomembranes: A Spin Label Study of the Effects of Ethanol 네이버 미소장
3 Membrane-disordering action of ethanol: variation with membrane cholesterol content and depth of the spin label probe. 네이버 미소장
4 Cholesterol blocks the disordering effects of ethanol in biomembranes. 네이버 미소장
5 Ethanol Disordering of Spin-Labeled Mouse Brain Membranes: Correlation with Genetically Determined Ethanol Sensitivity of Mice 네이버 미소장
6 Effects of ethanol on structural parameters of rat brain membranes: relationship to genetic differences in ethanol sensitivity. 네이버 미소장
7 Chronic ethanol consumption alters effects of ethanol in vitro on brain membrane structure of high alcohol sensitivity and low alcohol sensitivity rats. 네이버 미소장
8 Effects of chlorpromazine·HCl on the structural parameters of bovine brain membranes 소장
9 Effects of dimyristoylphosphatidylethanol on the structural parameters of neuronal membranes 소장
10 The effect of ethanol on the physical properties of neuronal membranes 소장
11 Nature 네이버 미소장
12 Do general anaesthetics act by competitive binding to specific receptors? 네이버 미소장
13 Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects. 네이버 미소장
14 Ethanol-induced disordering of membranes from different age groups of C57BL/6NNIA mice. 네이버 미소장
15 The effects of drugs on membrane fluidity. 네이버 미소장
16 Location and interaction of N-(9-anthroyloxy)-stearic acid probes incorporated in phosphatidylcholine vesicles 네이버 미소장
17 Properties of phosphatidylcholine bilayers as revealed by mixed-acyl phospholipid fluorescent probes containing n-(9-anthroyloxy) fatty acids. 네이버 미소장
18 Properties and the locations of a set of fluorescent probes sensitive to the fluidity gradient of the lipid bilayer. 네이버 미소장
19 An assessment of the fluidity gradient of the lipid bilayer as determined by a set of n-(9-anthroyloxy) fatty acids (n = 2, 6, 9, 12, 16). 네이버 미소장
20 Static and dynamic components of renal cortical brush border and basolateral membrane fluidity: role of cholesterol. 네이버 미소장
21 Amphiphilic effects of local anesthetics on rotational mobility in neuronal and model membranes. 네이버 미소장
22 The General lipid Composition and Aminophospholipid Asymmetry of Synaptosomal Plasma Membrane Vesicles Isolated from Bovine Cerebral Cortex 네이버 미소장
23 Comparison of Several Procedures for the Preparation of Synaptosomal Plasma Membrane Vesicles 소장
24 Yun I, Yang MS, Kim IS, Kang JS. Bulk vs. transbilayer effects of ethanol on the fluidity of the plasma membrane vesicles of cultured Chinese hamster ovary cells. Asia Pacific J Pharmacol. 1993;8;9-16. 미소장
25 The effect of ethanol on lateral and rotational mobility of plasma membrane vesicles isolated from cultured Mar 18.5 hybridoma cells. 네이버 미소장
26 Effects of ethanol on lateral and rotational mobility of plasma membrane vesicles isolated from cultured mouse myeloma cell line Sp2/0-Ag14. 네이버 미소장
27 Protein measurement with the Folin phenol reagent. 네이버 미소장
28 A fluorescence study of apolipoprotein localization in relation to lipids in serum low density lipoproteins. 네이버 미소장
29 Charged anesthetics selectively alter plasma membrane order. 네이버 미소장
30 Transbilayer effects of ethanol on fluidity of brain membrane leaflets. 네이버 미소장
31 Acute and chronic effects of ethanol on transbilayer membrane domains. 네이버 미소장
32 Investigation of human erythrocyte ghost membranes with intramolecular excimer probes. 네이버 미소장
33 Fluidity and Function of Hepatocyte Plasma Membranes 네이버 미소장
34 Stubbs CD, Williams BW. Fluorescence in membranes: Fluorescence Spectroscopy in Biochemistry. Vol 3. New York: Plenum Press; 1992. 231-263 p. 미소장
35 Transbilayer movement of cholesterol in the human erythrocyte membrane. 네이버 미소장
36 Asymmetry of lipid dynamics in human erythrocyte membranes studied with impermeant fluorophores. 네이버 미소장
37 Lipid fluidity of the individual hemileaflets of human erythrocyte membranes. 네이버 미소장
38 Asymmetric distribution of a fluorescent sterol in synaptic plasma membranes: effects of chronic ethanol consumption. 네이버 미소장
39 Effects of benzyl alcohol on erythrocyte shape, membrane hemileaflet fluidity and membrane viscoelasticity. 네이버 미소장
40 Asymmetric lipid fluidity in human erythrocyte membrane: new spin-label evidence. 네이버 미소장
41 Curtain CC, Gordon LM, Aloia RC. The role of cholesterol in regulating membrane fluidity: Advances in Membrane Fluidity. Vol 2. New York: Alan R Liss; 1988. 1-15 p. 미소장
42 Regulation of transbilayer distribution of a fluorescent sterol in tumor cell plasma membranes. 네이버 미소장
43 Transmembrane distribution of sterol in the human erythrocyte. 네이버 미소장
44 Amphiphilic effects of dibucaine·HCl on rotational mobility of n-(9-anthroyloxy)stearic acid in neuronal and model membranes 네이버 미소장
45 Janoff AS, Boni LT, Rauch J. Phase-defined domain in biological membranes: Advances in Membrane Fluidity. Vol 2. New York: Alan R Liss; 1988. 101-109 p. 미소장
46 Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity. 네이버 미소장
47 Synthesis and use of the n-bromododecane-1,12-diols as conformational probes for general anesthetic target sites. 네이버 미소장
48 Thermodynamics of anesthetic/protein interactions. Temperature studies on firefly luciferase 네이버 미소장
49 Neuron membranes: anaesthetics on the mind. 네이버 미소장
50 Do general anaesthetics act by competitive binding to specific receptors? 네이버 미소장
51 Molecular and cellular mechanisms of general anaesthesia. 네이버 미소장
52 Modulation of the General Anesthetic Sensitivity of a Protein: A Transition Between Two Forms of Firefly Luciferase 네이버 미소장
53 Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal 네이버 미소장
54 Gonzales RA, Hoffman PL. Receptor-gated ion channels may be selective CNS targets for ethanol. Trends Pharmacol Sci. 1991;12:1-3. 미소장
55 Ex vivo binding of t-[35S )butylbicyclophosphorothionate: a biochemical tool to study the pharmacology of ethanol at the gamma-aminobutyric acid-coupled chloride channel. 네이버 미소장
56 Binding of specific ligands to muscarinic receptors alters the fluidity of membrane fragments from rat brain A fluorescence polarization study with lipid-specific probes 네이버 미소장

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기