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Lck Interacting Membrane protein (LIME) was previously characterized as a transmembrane adaptor protein media-ting TCR-dependent T cell activation. Here, we show that LIME associates with Vav in response to TCR stimulation and is required for Vav guanine nucleotide exchange factor (GEF) activity for Rac1. Consistent with this finding, actin polymerization at the immunological synapse (IS) was markedly enhanced by overexpression of LIME, but was reduced by expression of a LIME shRNA. Moreover, TCR-mediated cell adhesion to ICAM-1, laminin, or fibro-nectin was downregulated by expression of LIME shRNA. In addition, in the IS, LIME but not LAT was found to localize at the peripheral-supramolecular activation cluster (p-SMAC) where the integrins were previously shown to be localized. Together, these results establish LIME as a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of Vav.

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기사명 저자명 페이지 원문 목차
Compartmentalization of vertebrate optic neuroephithelium : external cues and transcription factors Hyoung-Tai Kim, Jin Woo Kim pp.317-324

Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis Sunbae Lee, Yun Soo Bae pp.325-334

Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells Sung Mi Ju, Ah Ra Goh, Dong-Joo Kwon, Gi Soo Youn, Hyung-Joo Kwon, Yong Soo Bae, Soo Young Choi, Jinseu Park pp.335-341

Nicotinic acetylcholine receptor α7 and β4 subunits contribute nicotine-induced apoptosis in periodontal ligament stem cells So Yeon Kim, Kyung Lhi Kang, Jeong-Chae Lee, Jung Sun Heo pp.343-350

Prioritization of SNPs for genome-wide association studies using an interaction model of genetic variation, gene expression, and trait variation Hyojung Paik, Junho Kim, Sunjae Lee, Hyoung-Sam Heo, Cheol-Goo Hur, Doheon Lee pp.351-361

Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein(WASP)-family verprolin-homologous protein 2(WAVE2)-mediated invasive migration of B16 mouse melanoma cells Sun Joo Park, Yong Tae Kim, You Jin Jeon pp.363-369

Prostaglandin E₂ blocks menadione-induced apoptosis through the Ras/Raf/Erk signaling pathway in promonocytic leukemia cell lines Hyun-Seok Yeo, Adeeb Shehzad, Young Sup Lee pp.371-378

Identification of tobacco proteins associated with the stem-loop 1 RNAs of Potato virus X Sang-Yun Cho, Won Kyong Cho, Kook-Hyung Kim pp.379-384

A genome-wide comparison of NB-LRR type of resistance gene analogs(RGA) in the plant kingdom Jungeun Kim, Chan Ju Lim, Bong-Woo Lee, Jae-Pil Choi, Sang-Keun Oh, Raza Ahmad, Suk-Yoon Kwon, Jisook Ahn, Cheol-Goo Hur pp.385-392

A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment Su Jeong Ryu, Ji Yeong Jeon, Jun Chang, Thomas J. Sproule, Derry C. Roopenian, Eun Young Choi pp.393-399

The transmembrane adaptor protein, linker for activation of T cells(LAT), regulates RANKL-induced osteoclast differentiation Kabsun Kim, Jung Ha Kim, Jang Bae Moon, Jongwon Lee, Han bok Kwak, Yong-Wook Park, Nacksung Kim pp.401-406

LIME mediates immunological synapse formation through activation of VAV Myoungsun Son, Inyoung Park, Ok-Hee Lee, Inmoo Rhee, Changwon Park, Yungdae Yun pp.407-414

Ectopic expression of Capsicum-specific cell wall protein Capsicum annuum senescence-delaying 1(CaSD1) delays senescence and induces trichome formation in Nicotiana benthamiana Eunyoung Seo, Seon-In Yeom, SungHwan Jo, Heejin Jeong, Byoung-Cheorl Kang, Doil Choi pp.415-422

참고문헌 (38건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. 네이버 미소장
2 Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. 네이버 미소장
3 Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. 네이버 미소장
4 Billadeau, D.D., Nolz, J.C., and Gomez, T.S. (2007). Regulation of T-cell activation by the cytoskeleton. Nat. Rev. Immunol. 7, 131- 143. 미소장
5 LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. 네이버 미소장
6 A System for Stable Expression of Short Interfering RNAs in Mammalian Cells 네이버 미소장
7 Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading: A Role for the Signal Transduction Adaptor LAT 네이버 미소장
8 T‐cell receptor signaling to integrins 네이버 미소장
9 Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. 네이버 미소장
10 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. 네이버 미소장
11 CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. 네이버 미소장
12 Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor 네이버 미소장
13 Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. 네이버 미소장
14 Deletion of the LIME adaptor protein minimally affects T and B cell development and function 네이버 미소장
15 Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation 네이버 미소장
16 Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling. 네이버 미소장
17 LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation. 네이버 미소장
18 Mechanisms for Segregating T Cell Receptor and Adhesion Molecules during Immunological Synapse Formation in Jurkat T Cells 네이버 미소장
19 Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. 네이버 미소장
20 Suppression of thymic development by the dominant-negative form of Gads 네이버 미소장
21 Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells 네이버 미소장
22 Lee, S.H., and Dominguez, R. (2010). Regulation of actin cytoskeleton dynamics in cells. Mol. Cells 29, 311-325. 미소장
23 Adapters in lymphocyte signaling. 네이버 미소장
24 Three-dimensional segregation of supramolecular activation clusters in T cells. 네이버 미소장
25 Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. 네이버 미소장
26 Park, D., and Yun, Y. (2001). Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domainbinding proteins. Mol. Cells 12, 244-249. 미소장
27 Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. 네이버 미소장
28 Immunological synapse and microclusters: the site for recognition and activation of T cells 네이버 미소장
29 p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. 네이버 미소장
30 T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster 네이버 미소장
31 Wange, R.L. (2000). LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. Sci. STKE 2000, RE1. 미소장
32 Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. 네이버 미소장
33 Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation 네이버 미소장
34 Yu, C.H., Wu, H.J., Kaizuka, Y., Vale, R.D., and Groves, J.T. (2010). Altered actin centripetal retrograde flow in physically restricted immunological synapses. PLoS One 5, e11878. 미소장
35 SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. 네이버 미소장
36 LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 네이버 미소장
37 Zhang, W., Sommers, C.L., Burshtyn, D.N., Stebbins, C.C., DeJarnette, J.B., Trible, R.P., Grinberg, A., Tsay, H.C., Jacobs, H.M., Kessler, C.M., et al. (1999). Essential role of LAT in T cell development. Immunity 10, 323-332. 미소장
38 Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues 네이버 미소장

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