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The aim of this study was to investigate whether the changes in the magnetization transfer ratio (MTR) histogram are related to specific characteristics of Parkinson’s disease (PD) and to investigate whether the MTR histogram parameters are associated with neurochemical dysfunction by performing in vivo proton magnetic resonance spectroscopy (1H-MRS). MTR and in vivo 1HMRS studies were performed on control mice (n = 10) and 1-methyl-1,2,3,6-tetrahydropyridine intoxicated mice (n = 10). All the MTR and in vivo 1H-MRS experiments were performed on a 9.4 T MRI/MRS system (Bruker Biospin, Germany) using a standard head coil. The protondensity fast spin echo (FSE) images and the T2-weighted spin echo (SE) images were acquired with no gap. Outer volume suppression (OVS), combined with the ultra-short echo-time stimulated echo acquisition mode (STEAM), was used for the localized in-vivo 1H-MRS. The quantitative analysis of metabolites was performed from the 1H spectra obtained in vivo on the striatum (ST) by using jMRUI (Lyon, France). The peak height of the MTR histograms in the PD model group was significantly lower than that in the control group (p < 0.05). The midbrain MTR values for volume were lower in the PD group than the control group(p < 0.05). The complex peak (Glx: glutamine+glutamate+ GABA)/creatine (Cr) ratio of the right ST in the PD group was significantly increased as compared to that of the control group. The present study revealed that the peak height of the MTR histogram was significantly decreased in the ST and substantia nigra, and a significant increase in the Glx/Cr ratio was found in the ST of the PD group, as compared with that of the control group. These findings could reflect the early phase of neuronal dysfunction of neurotransmitters.

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기사명 저자명 페이지 원문 목차
Analyses of the structure of group correlations in Korean financial markets Jeung Su Ko, Gyuchang Lim, Kyungsik Kim pp.1751-1758

Adaptive compensation for the nonlinearity error in a heterodyne interferometer Pyungjun Kim, Kiho Kim, Kwanho You pp.1759-1765

Charge-exchange and charge-conserving reactions on Mg, Ar, Zr, and Sn isotopes Myung-Ki Cheoun, Eunja Ha, Kiseok Choi, Youngshin Kwon, W.Y. So, K.S. Kim, C.H. Hyun, C.Y. Ryu, T.K. Choi pp.1766-1785

Searching for resonances in the unbound ^6^Be nucleus by using a radioactive ^7^Be beam K.Y. Chae, D.W. Bardayan, J.C. Blackmon, M.S. Smith, A.E. Champagne, R.P. Fitzgerald, D.W. Visser, J.J. Das, V. Guimarães, K.L. Jones … [et al.] pp.1786-1791

Study on the RF Set Point for the PEFP DTL by using a phase scan method Ji-Ho Jang, Hyeok-Jung Kwon, Yong-Sub Cho pp.1792-1796

Compact modeling of extremely scaled graphene FETs Jaehong Lee, Hyungcheol Shin, Hyun-Jong Chung, Jaeho Lee, Jinseong Heo, Heejun Yang, Sung-Hoon Lee, Sunae Seo pp.1797-1801

Superconducting properties of Ba₂Ca_7_Cu_8_O_16_(O_0.8+δ_F_1.2_) studied via reversible magnetization Yong-Tae Kwon, Young Cheol Kim, Heon-Jung Kim, Akira Iyo, Parasharam M. Shirage pp.1802-1806

Spin oscillations in a free molecular magnet Gwang-Hee Kim pp.1807-1811

Structural and magnetic properties of nanoparticle Mn-Zn-Ni ferrite powders grown by using a sol-gel method Won Oak Choi, Woo Hyun Kwon, Jae-Gwang Lee, Byung-Sub Kang, Kwang Pyo Chae pp.1812-1816

Tuning of the magnetocaloric effect in La manganites Il Jin Park, Chan Hyuk Rhee, Chin Mo Kim, In-Bo Shim, Chul Sung Kim, Sam Jin Kim pp.1817-1820

Parametric model dielectric functions of InAs for temperatures from 22 to 675 K Tae Jung Kim, Soon Yong Hwang, Jun Seok Byun, Mangesh S. Diware, Jun Young Kim, Young Dong Kim pp.1821-1825

Photoluminescence studies of ZnO thin films prepared using a laser-assisted sol-gel method Min Su Kim, Jewon Lee, Yangsoo Kim, Jae-Young Leem, Sang-heon Lee, Wonshoup So, Jae Hak Jung, Jong Su Kim pp.1826-1830

Optimizing the atomic force microscopic parameters for submicron IDT patterns M. Tavakoli, H. Hajghassem, M. Dousti, A. Habibzadeh pp.1831-1834

A delta-doped amorphous silicon thin-film transistor with high mobility and stability Pyunghun Kim, Kyung Min Lee, Eui-Wan Lee, Younjung Jo, Do-Hyung Kim, Hong-jae Kim, Key Young Yang, Hyunji Son, Hyun Chul Choi pp.1835-1839

Optimization of a photon rejecter to separate electronic noise in a photon-counting detector Hyo-Min Cho, Yu-Na Choi, Seung-Wan Lee, Young-Jin Lee, Hyun-Ju Ryu, Hee-Joung Kim pp.1840-1845

Total variation minimization-based spiral CT reconstruction in a dental panoramic imaging system for cost-effective, low-dose dental X-ray imaging D.K. Hong, S.H. Lee, H.S. Cho, J.E. Oh, M.S. Lee, H.J. Kim, Y.O. Park, U.K. Je, S.I. Choi, Y.S. Koo … [et al.] pp.1846-1851

MTR and In-vivo ¹H-MRS studies on mouse brain with parkinson's disease Moon-Hyun Yoon, Hyeon-Jin Kim, Jin-Yeung Chung, Ah-Reum Doo, Hi-Joon Park, Seung-Nam Kim, Bo-Young Choe pp.1852-1859

Evaluation of fatty liver by using in-phase and opposed-phase MR images and in-vivo proton MR spectroscopy Jae-Seung Lee, In-Chul Im, Eun-Hoe Goo, Hyong-Hu Park, Byung-Joon Kwak pp.1860-1865

Gd-EOB-DTPA-enhanced 3.0-Tesla MRI findings for the preoperative detection of focal liver lesions : comparison with iodine-enhanced multi-detector computed tomography Hyong-Hu Park, Eun-Hoe Goo, In-Chul Im, Jae-Seung Lee, Moon-Jib Kim, Byung-Joon Kwak, Woon-Kwan Chung, Kyung-Rae Dong pp.1866-1876

Effect of acquisition parameters on digital breast tomosynthesis : total angular range and number of projection views Young-Wook Choi, Hye-Suk Park, Ye-seul Kim, Hee-Joung Kim, Jae-Gu Choi pp.1877-1883

Evaluation of aortic regurgitation by using PC MRI : a comparison of the accuracies at different image plane locations Byeong-Gull Kim, Kyung-Soo Kim, Soon-Bae Kim, Woon-Kwan Chung, Jae-Hwan Cho, Yong-Soon Park pp.1884-1888

A study on the effects of a calcium drug on the bone mineral density(BMD) by using dual-energy X-ray absorptiometry(DXA) Eun-Hye Kim, Ho-Sung Kim, Kyung-Rae Dong, Yong-Soon Park, Woon-Kwan Chung, Jae-Hwan Cho pp.1889-1897

Dynamics of quasi-species models with a complex spin coherent state representation Mark Ancliff, Jeong-Man Park pp.1898-1905

Mathematical investigations of branch length similarity entropy profiles of shapes for various resolutions Wonju Jeon, Sang-Hee Lee pp.1906-1910

Correlation between ultra-high-energy cosmic rays and active galactic nuclei from the fermi large-area telescope Jihyun Kim, Hang Bae Kim pp.1911-1917

Multi-component Erlang distribution of plant seed masses and sizes San-Hong Fan, Hua-Rong Wei pp.1918-1921

참고문헌 (26건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
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