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Gangliosides play important roles in the control of several biological processes, including proliferation and transmembrane signaling. In this study, we demonstrate the effect of ganglioside GM1 on the proliferation of mouse induced pluripotent stem cells (miPSCs). The proliferation rate of miPSCs was lower than in mouse embryonic stem cells (mESCs). Fluorescence activated cell sorting analysis showed that the percentage of cells in the G2/M phase in miPSCs was lower than that in mESCs. GM1 was expressed in mESCs, but not miPSCs. To confirm the role of GM1 in miPSC proliferation, miPSCs were treated with GM1. GM1-treated miPSCs exhibited increased cell proliferation and a larger number of cells in the G2/M phase. Furthermore, phosphorylation of mitogen-activated protein kinases was increased in GM1- treated miPSCs.

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기사명 저자명 페이지 원문 목차
Tumor-associated autoantibodies as diagnostic and prognostic biomarkers Chang-Kyu Heo, Young Yil Bahk, Eun-Wie Cho pp.677-685

Mouse genetics : catalogue and scissors Young Hoon Sung, In-Jeoung Baek, Je Kyung Seong, Jin-Soo Kim, Han-Woong Lee pp.686-692

Structure and catalytic mechanism of human protein tyrosine phosphatome Seung Jun Kim, Seong Eon Ryu pp.693-699

Involvement of protein tyrosine phosphatases in adipogenesis : new anti-obesity targets? Kwang-Hee Bae, Won Kon Kim, Sang Chul Lee pp.700-706

Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA Hyo Jeong Son, Seung Cheol Ha, Eun Young Hwang, Eun-A Kim, Jee-Yin Ahn, Soo Young Choi, Sung-Woo Cho pp.707-712

Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells Jae-Sung Ryu, Kyu-Tae Chang, Ju-Taek Lee, Malg-Um Lim, Hyun-Ki Min, Yoon-Ju Na, Su-Bin Lee, Gislain Moussavou, Sun-Uk Kim, Ji-Su Kim … [et al.] pp.713-718

HER2 induces expression of leptin in human breast epithelial cells Yujin Cha, Youjin Kang, Aree Moon pp.719-723

The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells Hye-Eun Kim, Atsushi Ishihara, Seong-Gene Lee pp.724-729

p13 from group Ⅱ baculoviruses is a killing-associated gen Nan Lu, Enqi Du, Yangkun Liu, Hong Qiao, Lunguang Yao, Zishu Pan, Songya Lu, Yipeng Qi pp.730-735

In-silico and in-vitro based studies of Streptomyces peucetius CYP107N3 for oleic acid epoxidation Saurabh Bhattarai, Narayan Prasad Niraula, Jae Kyung Sohng, Tae-Jin Oh pp.736-741

Antiapoptotic effects of Phe140Asn, a novel human granulocyte colony-stimulating factor mutant in H9c2 rat cardiomyocytes Hee Kyoung Chung, Eun Mi Ko, Sung Woo Kim, Sung-June Byun, Hak-Jae Chung, Moosik Kwon, Hwi-Cheul Lee, Byoung-Chul Yang, Deug-Woo Han, Jin-Ki Park … [et al.] pp.742-747

Rationalization of allosteric pathway in Thermus sp. GH5 methylglyoxal synthase Shekufeh Zareian, Khosro Khajeh, Mohammad Pazhang, Bijan Ranjbar pp.748-753

참고문헌 (39건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors 네이버 미소장
2 Generation of germline-competent induced pluripotent stem cells 네이버 미소장
3 Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., Plath, K. and Hochedlinger, K. (2007) Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell. Stem. Cell 1, 55-70. 미소장
4 Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells 네이버 미소장
5 Reprogramming of pancreatic beta cells into induced pluripotent stem cells. 네이버 미소장
6 Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. 네이버 미소장
7 Hakomori, S. (1990) Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions. J. Biol. Chem. 265, 18713-1 8716. 미소장
8 Transport and sorting of membrane lipids. 네이버 미소장
9 Ganglioside/glycosphingolipid turnover: New concepts 네이버 미소장
10 Hakomori, S., Yamamura, S. and Handa, A. K. (1998) Signal transduction through glyco(sphingo)lipids. Introduction and recent studies on glyco(sphingo)lipid-enriched microdomains. Ann. N. Y. Acad. Sci. 845, 1-10. 미소장
11 Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells 소장
12 Developmental patterns of mST3GalV mRNA expression in the mouse: in situ hybridization using DIG-labeled RNA probes. 소장
13 Expression of Ganglioside GT1b in Mouse Embryos at DifferentDevelopmental Stages after Cryopreservation 소장
14 Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains 네이버 미소장
15 GM1 enhances dopaminergic markers in the brain of aged rats 네이버 미소장
16 Goettl, V. M., Wemlinger, T. A., Duchemin, A. M., Neff, N. H. and Hadjiconstantinou, M. (1999) GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats. Neuroscience 92, 991-1000. 미소장
17 Duan, J. G., Xiang, T., Chen, H. and Liu, M. (2007) Role of extrinsic ganglioside GM1 in proliferation and differentiation of neural stem cells. Sichuan Da Xue Xue Bao Yi Xue Ban 38, 260-263. 미소장
18 Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway. 네이버 미소장
19 Over-expression of GM1 enhances cell proliferation with epidermal growth factor without affecting the receptor localization in the microdomain in PC12 cells. 네이버 미소장
20 Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1. 네이버 미소장
21 Glycosphingolipid Synthesis Inhibitor Represses Cytokine-Induced Activation of the Ras-MAPK Pathway in Embryonic Neural Precursor Cells 네이버 미소장
22 Ganglioside GM1 Activates the Mitogen‐Activated Protein Kinase Erk2 and p70 S6 Kinase in U‐1242 MG Human Glioma Cells 네이버 미소장
23 Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. 네이버 미소장
24 Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily. 네이버 미소장
25 The expression and functions of glycoconjugates in neural stem cells 네이버 미소장
26 Stem Cell Glycolipids 네이버 미소장
27 Carbohydrate antigen expression in murine embryonic stem cells and embryos. I. Lacto and neo-lacto determinants. 네이버 미소장
28 Kwak, D. H., Yu, K., Kim, S. M., Lee, D. H., Jung, J. U., Seo, J. W., Kim, N., Lee, S., Jung, K. Y., You, H. K., Kim, H. A. and Choo, Y. K. (2006) Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells. Exp. Mol. Med. 38, 668-676. 미소장
29 Effects of daunorubicin on ganglioside expression and neuronal differentiation of mouse embryonic stem cells 네이버 미소장
30 Biology of gangliosides: neuritogenic and neuronotrophic properties. 네이버 미소장
31 Leon, A., Dal Toso, R., Presti, D., Benvegnu, D., Facci, L., Kirschner, G., Tettamanti, G. and Toffano, G. (1988) Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: II. Modulatory effects of gangliosides. J. Neurosci. 8, 746-753. 미소장
32 Ganglioside GM1 Binds to the Trk Protein and Regulates Receptor Function 네이버 미소장
33 Wang, Q., Wang, Z. P., Xu, Q. and Bao, N. (2009) Effects of ganglioside 1 and nerve growth factor on the proliferation of neural stem cells in vitro. Zhongguo Dang Dai Er Ke Za Zhi 11, 841-845. 미소장
34 Duan, J. G., Xiang, T., Chen, H. and Liu, M. (2007) Role of extrinsic ganglioside GM1 in proliferation and differentiation of neural stem cells. Sichuan Da Xue Xue Bao Yi Xue Ban 38, 260-263. 미소장
35 GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain 네이버 미소장
36 Ferrari, G. and Greene, L. A. (1998) Promotion of neuronal survival by GM1 ganglioside. Phenomenology and mechanism of action. Ann. N. Y. Acad. Sci. 845, 263-273. 미소장
37 Promotion of neurite outgrowth by protein kinase inhibitors and ganglioside GM1 in neuroblastoma cells involves MAP kinase ERK1/2 네이버 미소장
38 Jung, J. U., Ko, K., Lee, D. H., Chang, K. T. and Choo, Y. K. (2009) The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells. Exp. Mol. Med. 41, 935-945. 미소장
39 Cell-Specific Deletion of Glucosylceramide Synthase in Brain Leads to Severe Neural Defects after Birth 네이버 미소장

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