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Hizikia fusiformis, a brown alga that is widely consumed in Korea, Japan, and China, possesses a number of potentially benef icial compounds, including antioxidants and anticoagulants. However, the molecular mechanisms of H. fusiformis in hepatoma cells have not been elucidated. This study investigated the antiproliferative effect and mechanism of action of a glycoprotein from H. fusiformis (HFGP) in HepG2 human hepatoma cells. In an MTS assay, 25μg/mL HFGP inhibited the proliferation of HepG2 cells by 52.36±2.37%. HFGP caused the dose-dependent growth inhibition of HepG2 cells by inducing apoptosis and a sub-G1 phase arrest. The antiproliferative activity of HFGP was conf irmed based on the expression of several apoptosis-related proteins, which was assessed by Western blot analysis. The expressions of Fas, Fas-associated death domain protein, Bax, and Bad was signif icantly up-regulated in HFGP-treated cells, and HFGP induced the translocation of Bax to mitochondria and the release of cytochrome c into the cytosol. Therefore, HFGP might be useful in the treatment of liver cancer.
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참고문헌 (30건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Berg CP, Engels IH, Rothbart A, Lauber K, Renz A, Schlosser SF, Schulze-Osthoff K and Wesselberg S. 2001. Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis. Cell Death Differ 8, 1197-1206. | 미소장 |
| 2 | Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line.  |
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| 3 | Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death |
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| 4 | Bowen JM, Gibson RJ, Cummins AG and Keefe DM. 2006. Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer 14, 713-731. | 미소장 |
| 5 | Mitochondrial factors with dual roles in death and survival. |
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| 6 | Regulation of pro-apoptotic BH3-only proteins and its contribution to cancer progression and chemoresistance |
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| 7 | Mitochondria as therapeutic targets for cancer chemotherapy. |
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| 8 | Cell-cycle control and its watchman. |
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| 9 | The role of mitochondria in apoptosis. | 소장 |
| 10 | Anticarcinogenic Effects of Extracts from Gloiopeltis tenax | 소장 |
| 11 | Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells |
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| 12 | Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. |
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| 13 | Kim JA and Lee JM. 2004. The change of biologically functional compounds and antioxidant activities in Hizikia fusiformis with drying methods. Korean J Food Culture 19, 200-208. | 미소장 |
| 14 | Kim KI, Seo HD, Lee HS, Jo HY and Yang HC. 1998. Studies on the blood anticoagulant polysaccharide isolated from hot water extracts of Hizikia fusiforme. J Korean Soc Food Sci Nutr 27, 1204-1210. | 미소장 |
| 15 | Effects of Hijikia fusiforme Ethanol Extract on Antioxidative Enzymes in Ethanol-induced Hepatotoxicity of Rat Liver | 소장 |
| 16 | Molecular interaction map of the mammalian cell cycle control and DNA repair systems. |
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| 17 | Koo JG, Choi YS and Kwak JK. 2001. Blood-anticoagulant activity of fucoidans from sporophylls of Unbaria pinnatif ida, Laminaria religiosa, Hizikia fusiforme and Sargassum fulvellum in Korea. J Korean Fish Soc 34, 515-520. | 미소장 |
| 18 | Labi V, Erlacher M, Kiessling S and Villunger A. 2006. BH3- only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ 13, 1325-1338. | 미소장 |
| 19 | Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. |
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| 20 | Li B, Wei XJ, Sun JL and Xu SY. 2006. Structural investigation of a fucoidan containing a fucose-free core from the brown seaweed, Hizikia fusiforme. Carbohydr Res 341, 1135- 1146. | 미소장 |
| 21 | Lim SB, Kim SH, Ko YH, Oh CK, Oh MC, Park JS and Ko YG. 1995. Extraction yields of Hizikia fusiforme and Aloe vera linne by supercritical carbon dioxide and antimicrobial activity of their extracts. Korean J Food Sci Technol 27, 68- 73. | 미소장 |
| 22 | Apoptosis by death factor. |
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| 23 | Park KE, Jang MS, Lim CW, Kim YK, Seo Y, and Park HY.2005. Antioxidant activity on ethanol extract from boiledwaterof Hizikia fusiformis. J Korean Soc Appl Biol Chem48, 435-439. | 미소장 |
| 24 | Bcl-2-family proteins and hematologic malignancies: history and future prospects. |
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| 25 | Ryu BH, Kim DS, Cho KJ and Sin DB. 1989. Antitumor activity of seaweeds toward sarcoma-180. Korea J Food Sci Technol 21, 595-600. | 미소장 |
| 26 | Schreiber V, Dantzer F, Ame JC and de Murcia G. 2006. Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol 7, 517-528. | 미소장 |
| 27 | Role of Bcl-2 family members in anoxia induced cell death. |
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| 28 | Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. |
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| 29 | Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. |
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| 30 | Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents. |
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