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Rehmanniae Radix Preparata, the steamed root of Rehmannia glutinosa Libosch, has been widely used for the treatment of inflammatory conditions in Oriental medicines. In this study we evaluated the effects of 2,5-dihydroxyacetophenone (DHAP) isolated from Rehmanniae Radix Preparata on inflammatory responses in lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophages. LPS-stimulated RAW264.7 cells were used to investigate the anti-inflammatory activity of DHAP on the production of inflammatory mediators such as nitric oxide (NO), inducible NO synthase (iNOS),tumor necrosis factor-a (TNF-a), and interleukin (IL)-6. DHAP significantly inhibited NO production via the suppression of iNOS expression and significantly decreased levels of the pro-inflammatory cytokines TNF-a and IL-6 via the downregulation of their mRNA expression in LPS-stimulated RAW264.7 cells. DHAP potently inhibited the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-jB (NF-jB) p65 in LPSstimulated cells. These results indicate that DHAP inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-jB signaling pathways. Our results suggest that DHAP from Rehmanniae Radix Preparata has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions.

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기사명 저자명 페이지 원문 목차
2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages Yunkyung Han, Hyo Won Jung, Joo Young Lee, Ju Sun Kim, Sam Sik Kang, Yeong Shik Kim, Yong-Ki Park pp.505-510

Exposure to probiotic Lactobacillus acidophilus L-92 modulates gene expression profiles of epithelial Caco-2 cells Sae Yanagihara, Shinji Fukuda, Hiroshi Ohno, Naoyuki Yamamoto pp.511-519

Bactericidal activity of soymilk fermentation broth by in vitro and animal models Yi-Ping Chin, Ko-Chung Tsui, Mei-Chieh Chen, Cheng-Yi Wang, Chin-Yuh Yang, Yuh-Ling Lin pp.520-526

Extract from Dioscorea batatas ameliorates insulin resistance in mice fed a high-fat diet Soyoung Kim, Hyejeong Jwa, Yasuko Yanagawa, Taesun Park pp.527-534

Drinking deep seawater decreases serum total and low-density lipoprotein-cholesterol in hypercholesterolemic subjects Zhao-Yang Fu, Feili Lo Yang, Hsin-Wen Hsu, Yi-Fa Lu pp.535-541

Effect on tumor necrosis factor-α production and antioxidant ability of black alder, as factors related to its anti-inflammatory properties Nuria Acero, Dolores Muñoz-Mingarro pp.542-548

Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice Dirleise Colle, Leticia Priscilla Arantes, Priscila Gubert, Sônia Cristina Almeida da Luz, Margareth Linde Athayde, João Batista Teixeira Rocha, Félix Alexandre Antunes Soares pp.549-556

Protective effect of sodium ferulate on acetaldehyde-treated precision-cut rat liver slices Yu Guo, Xiao-Qian Wu, Chun Zhang, Zhang-Xiu Liao, Yong Wu, Hui Wang pp.557-562

Detection of genotoxic, cytotoxic, and protective activities of Eugenia dysenterica DC.(Myrtaceae) in mice Pabline Marinho Vieira, Eduardo Veronezi, Carolina R. Silva, Lee Chen-Chen pp.563-567

Royal jelly increases collagen production in rat skin after ovariectomy Hye Min Park, Min Hyoung Cho, Yunhi Cho, Sun Yeou Kim pp.568-575

Chemopreventive effects of cardamom(Elettaria cardamomum L.) on chemically induced skin carcinogenesis in Swiss albino mice Samir Qiblawi, Awdah Al-Hazimi, Mohammed Al-Mogbel, Ashfaque Hossain, Debasis Bagchi pp.576-580

Apple pomace, a by-product from the Asturian cider industry, inhibits herpes simplex virus types 1 and 2 in vitro replication : study of its mechanisms of action Ángel L. Álvarez, Santiago Melón, Kevin P. Dalton, Inés Nicieza, Annele Roque, Belén Suárez, Francisco Parra pp.581-587

참고문헌 (20건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Anti-inflammatory effect of the water fraction from hawthorn fruit on LPS-stimulated RAW 264.7 cells. 소장
2 Wang CC, Choy CS, Liu YH, Cheah KP, Li JS, Wang JTJ, Yu WY, Lin CW, Cheng HW, Hu CM: Protective effect of dried safflower petal aqueous extract and its main constituent, carthamus yellow, against lipopolysaccharide-induced inflammation in RAW264.7 macrophages. J Sci Food Agric 2010;91:218–225. 미소장
3 Fan J, Liu Z, Luo T, Xi Z, Song J, Liu B: Modified si-miao-san extract inhibits the release of inflammatory mediators from lipopolysaccharide-stimulated mouse macrophages. J Ethnopharmacol 2010;129:5–9. 미소장
4 Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kB in LPS-stimulated BV-2 microglial cells 소장
5 Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM: Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW264.7 cells. J Ethnopharmacol 2009;123:97–105. 미소장
6 Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling. 네이버 미소장
7 Ethanol Extract of Elaeocarpus petiolatus Inhibits Lipopolysaccharide-Induced Inflammation in Macrophage Cells 네이버 미소장
8 Zha LY, Mao LM, Lu XC, Deng H, Ye JF, Chu XW, Sun SX, Luo HJ: Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW264.7 cells by attenuation of NF-jB mediated nitric oxide synthase expression. Bioorg Med Chem Lett 2011;21:2415–2418. 미소장
9 Wen-Pi-Tang-Hab-Wu-Ling-San extract inhibits the release of inflammatory mediators from LPS-stimulated mouse macrophages 네이버 미소장
10 Chae HJ, Kim HR, Kim DS, Woo ER, Cho YG, Chae SW: Saengji-hwang has a protective effect on adriamycin-induced cytotoxicity in cardiac muscle cells. Life Sci 2005;76:2027–2042. 미소장
11 Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer 네이버 미소장
12 Amelioration of diabetic nephropathy by dried Rehmanniae Radix (Di Huang) extract. 네이버 미소장
13 Phytochemical Studies on Rehmanniae Radix Preparata 소장
14 Zhang RX, Li MX, Jia ZP: Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117:199–214. 미소장
15 Flowers of Inula japonica Attenuate Inflammatory Responses. 소장
16 Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kB activation 네이버 미소장
17 Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-kB translocation in LPS stimulated RAW 264.7 cells 네이버 미소장
18 Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect. 네이버 미소장
19 Shapira L, Soskolne WA, Houri Y, Barak V, Halabi A, Stabholz A: Protection against endotoxic shock and lipopolysaccharideinduced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect Immun 1996;64:825–828. 미소장
20 Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice 네이버 미소장

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