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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Flaxseed (FS) is an oilseed rich in phytoestrogens and n-3 polyunsaturated fatty acids, compounds that may attenuate bone loss during aging. We previously demonstrated using the ovariectomized (OVX) rat model of postmenopausal osteoporosis that 10% dietary FS combined with low-dose estrogen therapy (LD) preserves vertebral bone mass and strength more so than either treatment alone. However, it was prudent to also consider the effect of this intervention on uterine tissue as LD, and possibly FS, may have estrogenic, and thus negative, effects on uterine tissue. The present study investigated if FS enhances the estrogenic effect of LD on markers of uterine health in OVX rats. Three-month-old rats were randomized to groups: (1) SHAM, (2) OVX, (3) OVX+FS, (4) OVX+LD, or (5) OVX+FS+LD. Ground FS was added to the AIN-93M diet (100 g/kg of diet), and LD was delivered by subcutaneous implant (0.42 μg of 17β-estradiol/kg of body weight/day) to mimic LD in postmenopausal women. After 12 weeks, histological analyses of uterine tissue demonstrated flattened or cuboidal luminal epithelia organized in a single layer in the OVX group, while FS, LD, and FS+LD induced a single layer of elongated luminal epithelia, columnar in shape. The SHAM group had the greatest epithelial mass. Cell proliferation was similar among all OVX groups. Therefore FS and FS+LD similarly induce estrogen-like effects on the morphology of luminal epithelia that are weaker than in the SHAM group without inducing cell proliferation in OVX rats. Thus, FS does not enhance the estrogenic effect of LD on markers of uterine health in OVX rats.

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기사명 저자명 페이지 원문 목차
Resveratrol in cholesterol metabolism and atherosclerosis Iryna Voloshyna, Syed M. Hussaini, Allison B. Reiss pp.763-773

Hematopoietic effect of Bacillus subtilis-fermented antler extract on phenylhydrazine-induced hemolytic anemia in Sprague–Dawley rats Sang Hun Lee, Hyung Joo Suh, Hyun-Sun Lee, Yooheon Park, Jang-Woo Park, Eun Young Jung pp.774-780

Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle Jin-Nyoung Ho, Ho-Geun Yoon, Chang-Soo Park, Sunoh Kim, Woojin Jun, Ryowon Choue, Jeongmin Lee pp.781-787

Resveratrol inhibits inflammation induced by heat-killed Listeria monocytogenes Dae-Weon Park, Jin-Sik Kim, Byung-Rho Chin, Suk-Hwan Baek pp.788-794

Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats Carolina Guerini de Souza, José Augusto Sattler, Adriano Martimbianco de Assis, Anderson Rech, Marcos Luiz Santos Perry, Diogo Onofre Souza pp.795-801

Effect of dietary blueberry pomace on selected metabolic factors associated with high fructose feeding in growing Sprague–Dawley rats Ramesh C. Khanal, Luke R. Howard, Samuel E. Wilkes, Theodore J. Rogers, Ronald L. Prior pp.802-810

Anti-obesity effects of Boussingaulti gracilis Miers var. pseudobaselloides Bailey via activation of AMP-activated protein kinase in 3T3-L1 cells Hana Kim, Se-Young Choung pp.811-817

Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma Seong Hee Shim, Joon Mo Kim, Chul Young Choi, Chan Yun Kim, Ki Ho Park pp.818-823

Classification of Sasang constitutional body types using immunostimulatory activities of constitution-specific herbal extracts in human primary immune cells Jae-Ho Choi, Mi Ja Chung, Deog-Hwan Oh pp.824-834

The constituents of essential oil: antimicrobial and antioxidant activity of Micromeria congesta Boiss. & Hausskn. ex Boiss. from East Anatolia Emine Nur Herken, Ali Celik, Mustafa Aslan, Nilüfer Aydınlık pp.835-839

Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms Márcia Constantino Colli, Adelar Bracht, Andréa Assunção Soares, Andréa Luisa de Oliveira, Cinthia Gandolfi Bôer, Cristina Giatti Marques de Souza, Rosane Marina Peralta pp.840-845

Flaxseed does not enhance the estrogenic effect of low-dose estrogen therapy on markers of uterine health in ovariectomized rats Sandra M. Sacco, Jessica M.Y. Jiang, Lilian U. Thompson, Wendy E. Ward pp.846-850

Anti-inflammatory and neuroactive properties of selected fruit extracts Kelly C. Heim, Paul Angers, Sebastien Léonhart, Barry W. Ritz pp.851-854

참고문헌 (34건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. 네이버 미소장
2 Anderson GL, Limacher M, Assaf AR, et al.: Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 2004;291:1701–1712. 미소장
3 Grady D, Gebretsadik T, Kerlikowske K, Ernster V, Petitti D: Hormone replacement therapy and endometrial cancer risk: a meta-analysis. Obstet Gynecol 1995;85:304–313. 미소장
4 Low-dose estrogen therapy for prevention of osteoporosis: working our way back to monotherapy. 네이버 미소장
5 Effects of Ultralow-Dose Transdermal Estradiol on Bone Mineral Density: A Randomized Clinical Trial 네이버 미소장
6 Ettinger B: Rationale for use of lower estrogen doses for postmenopausal hormone therapy. Maturitas 2007;57:81–84. 미소장
7 Samsioe G, Dvorak V, Genazzani AR, et al.: One-year endometrial safety evaluation of a continuous combined transdermal matrix patch delivering low-dose estradiol-norethisterone acetate in postmenopausal women. Maturitas 2007;57:171–181. 미소장
8 Similar efficacy of low and standard doses of transdermal estradiol in controlling bone turnover in postmenopausal women. 네이버 미소장
9 Type and route of estrogen administration. 네이버 미소장
10 Randomized trial of effect of transdermal continuous combined hormone replacement therapy on cardiovascular risk markers. 네이버 미소장
11 Grady D: Clinical practice. Management of menopausal symptoms. N Engl J Med 2006;355:2338–2347. 미소장
12 Botanical dietary supplement use in peri- and postmenopausal women. 네이버 미소장
13 Singh SR, Levine MA: Natural health product use in Canada: analysis of the National Population Health Survey. Can J Clin Pharmacol 2006;13:e240–e250. 미소장
14 Sacco SM, Jiang JM, Reza-López S, Ma DW, Thompson LU, Ward WE: Flaxseed does not antagonize the effect of ultra-lowdose estrogen therapy on bone mineral density and biomechanical bone strength in ovariectomized rats. J Environ Health Toxicol A 2009;72:1209–1216. 미소장
15 Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats. 네이버 미소장
16 Chen J, Saggar JK, Corey P, Thompson LU: Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice. J Nutr 2009;139:2061–2066. 미소장
17 Dietary Phytoestrogen Intake—Lignans and Isoflavones—and Breast Cancer Risk (Canada) 네이버 미소장
18 Dietary Flaxseed Alters Tumor Biological Markers in Postmenopausal Breast Cancer 네이버 미소장
19 Mammalian lignan production from various foods 네이버 미소장
20 Wang LQ, Meselhy MR, Li Y, Qin GW, Hattori M: Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone. Chem Pharm Bull (Tokyo) 2000;48:1606–1610. 미소장
21 Origin of lignans in mammals and identification of a precursor from plants. 네이버 미소장
22 Production and metabolism of lignans by the human faecal flora. 네이버 미소장
23 Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator. 네이버 미소장
24 Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat. 네이버 미소장
25 Bergman Jungestrom M, Thompson LU, Dabrosin C: Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo. Clin Cancer Res 2007;13:1061–1067. 미소장
26 Penttinen-Damdimopoulou PE, Power KA, Hurmerinta TT, Nurmi T, van der Saag PT, Makela SI: Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice. Mol Nutr Food Res 2009;53:996–1006. 미소장
27 Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. 네이버 미소장
28 Power KA, Ward WE, Chen JM, Saarinen NM, Thompson LU: Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts. J Toxicol Environ Health A 2007;70:1888–1896. 미소장
29 Dietary Flaxseed Enhances the Inhibitory Effect of Tamoxifen on the Growth of Estrogen-Dependent Human Breast Cancer (MCF-7) in Nude Mice 네이버 미소장
30 Canadian Council on Animal Care: Guide to the Care and Use of Experimental Animals, Vol. 1. Canadian Council on Animal Care, Ottawa, Canada, 1993. 미소장
31 Reeves PG, Nielsen FH, Fahey GC Jr: AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet. J Nutr 1993;123:1939–1951. 미소장
32 North American Menopause Society: Hormone products for postmenopausal use in the United States and Canada. 2010. www.menopause.org/htcharts.pdf (accessed April 16, 2011). 미소장
33 Lindsay R, Gallagher JC, Kleerekoper M, Pickar JH: Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women. JAMA 2002;287:2668–2676. 미소장
34 P53 and PCNA immunoexpression in endometrial carcinomas. 네이버 미소장

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