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Mesenchymal stem cells (MSCs) are often known to have a therapeutic potential in the cell-mediated repair for fatal or incurable diseases. In this study, canine umbilical cord MSCs (cUC-MSCs) were isolated from umbilical cord matrix (n = 3) and subjected to proliferative culture for 5 consecutive passages. The cells at each passage were characterized for multipotent MSC properties such as proliferation kinetics, expression patterns of MSC surface markers and self-renewal associated markers, and chondrogenic differentiation. In results, the proliferation of the cells as determined by the cumulative population doubling level was observed at its peak on passage 3 and stopped after passage 5, whereas cell doubling time dramatically increased after passage 4. Expression of MSC surface markers (CD44, CD54, CD61, CD80, CD90 and Flk-1), molecule (HMGA2) and pluripotent markers (sox2, nanog) associated with self-renewal was negatively correlated with the number of passages. However, MSC surface marker (CD105) and pluripotent marker (Oct3/4) decreased with increasing the number of subpassage. cUC-MSCs at passage 1 to 5 underwent chondrogenesis under specific culture conditions, but percentage of chondrogenic differentiation decreased with increasing the number of subpassage. Collectively, the present study suggested that sequential subpassage could affect multipotent properties of cUC-MSCs and needs to be addressed before clinical applications.

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기사명 저자명 페이지 원문 목차
Polymorphism of NLRP3 gene and association with susceptibility to digestive disorders in rabbit Yu Yang, Gong-Wei Zhang, Shi-Yi Chen, Jin Peng, Song-Jia Lai pp.455-462

Association of the porcine cluster of differentiation 4 gene with T lymphocyte subpopulations and its expression in immune tissues Jingen Xua, Yang Liu, Weixuan Fu, Jiying Wang, Wenwen Wang, Haifei Wang, Jianfeng Liu, Xiangdong Ding, Qin Zhang pp.463-469

Genetic parameter estimation in seedstock swine population for growth performances Jae Gwan Choi, Chung Il Cho, Im Soo Choi, Seung Soo Lee, Tae Jeong Choi, Kwang Hyun Cho, Byoung Ho Park, Yun Ho Choy pp.470-475

Comparative analysis of Nkx2-5/GATA4/TBX5 expression in chicken, quail and chicken-quail hybrids during the early stage of cardiac development in embryos Qian Ban, Xiaojun Liu, Wenqiao Hui, Danying Chen, Zongsheng Zhao, Bin Jia pp.476-482

Polymorphisms in the promoter region of the Chinese bovine PPARGC1A gene M.J. Li, M. Liu, D. Liu, X.Y. Lan, C.Z. Lei, D.Y. Yang, H. Chen pp.483-487

Ovarian follicular dynamics, ovarian follicular growth, oocyte yield, in vitro embryo production and repeated oocyte pick up in Thai native heifers undergoing superstimulation J. Chasombat, T. Nagai, R. Parnpai, T. Vongpralub pp.488-500

Effect of dipeptides on in vitro maturation, fertilization and subsequent embryonic development of porcine oocytes K.M.A. Tareq, Quzi Sharmin Akter, Hirotada Tsujii, M.A.M. Yahia Khandoker, Inho Choi pp.501-508

Effects of feeding corn-lablab bean mixture silages on nutrient apparent digestibility and performance of dairy cows Yongli Qu, Wei Jiang, Guoan Yin, Chunbo Wei, Jun Bao pp.509-516

The effect of plant extracts on in-vitro ruminal fermentation, methanogenesis and methane-related microbes in the rumen E.T. Kim, K.-S. Min, C.-H. Kim, Y.H. Moon, S.C. Kim, S.S. Lee pp.517-522

Effects of branched-chain amino acids on in vitro ruminal fermentation of wheat straw Hui Ling Zhang, Yong Chen, Xiao Li Xu, Yu Xia Yang pp.523-528

Effect of carbohydrate sources and levels of cotton seed meal in concentrate on feed intake, nutrient digestibility, rumen fermentation and microbial protein synthesis in young dairy bulls M. Wanapat, N. Anantasook, P. Rowlinson, R. Pilajun, P. Gunun pp.529-536

Effects of enzyme treated palm kernel expeller on metabolizable energy, growth performance, villus height and digesta viscosity in broiler chickens P. Saenphoom, J.B. Liang, Y.W. Ho, T.C. Loh, M. Rosfarizan pp.537-544

Development of gut microbiota in a mouse model of ovalbumin-induced allergic diarrhea under sub-barrier system Juan-Hong Wang, Song-Wei Fan, Wei-Yun Zhu pp.545-551

Immobilization of the antarctic Bacillus sp. LX-1 α-galactosidase on eudragit L-100 for the production of a functional feed additive Jaekoo Lee, Inkyung Park, Jaiesoon Cho pp.552-557

Earlier metabolizable energy intake level influences heat production during a following 3-day fast in laying hens D. Ning, Y.M. Guo, Y.W. Wang, Y.Z. Peng pp.558-563

The effect of level of crude protein and available lysine on finishing pig performance, nitrogen balance and nutrient digestibility M.E.E. Ball, E. Magowan, K.J. McCracken, V.E. Beattie, R. Bradford, F.J. Gordon, M.J. Robinson, S. Smyth, W. Henry pp.564-572

Evaluation of bacteriophage supplementation on growth performance, blood characteristics, relative organ weight, breast muscle characteristics and excreta microbial shedding in broilers J.P. Wang, L. Yan, J.H. Lee, I.H. Kim pp.573-578

Effects of supplementation of β-mannanase in corn-soybean meal diets on performance and nutrient digestibility in growing pigs J.N. Lv, Y.Q. Chen, X.J. Guo, X.S. Piao, Y.H. Cao, B. Dong pp.579-587

Effects of serial passage on the characteristics and chondrogenic differentiation of canine umbilical cord matrix derived mesenchymal stem cells K.S. Lee, S.-H. Cha, H.W. Kang, J.-Y. Song, K.W. Lee, K.B. Ko, H.T. Lee pp.588-595

Synergistic effects of electron-beam irradiation and leek extract on the quality of pork jerky during ambient storage Hyun-Joo Kim, Mingu Kang, Hae In Yong, Young Sik Bae, Samooel Jung, Cheorun Jo pp.596-602

참고문헌 (33건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Yield of human adipose-derived adult stem cells from liposuction aspirates 네이버 미소장
2 The Monoclonal Antibody SH-2, Raised against Human Mesenchymal Stem Cells, Recognizes an Epitope on Endoglin (CD105) 네이버 미소장
3 Aging of mesenchymal stem cell in vitro 네이버 미소장
4 Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. 네이버 미소장
5 Relationship between Donor Age and the Replicative Lifespan of Human Cells in Culture: A Reevaluation 네이버 미소장
6 Adipose tissue-derived stem cells from humans and mice differ in proliferative capacity and genome stability in long-term cultures. 네이버 미소장
7 Isolation, proliferation, cytogenetic, and molecular characterization and in vitro differentiation potency of canine stem cells from foetal adnexa: A comparative study of amniotic fluid, amnion, and umbilical cord matrix 네이버 미소장
8 Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro 네이버 미소장
9 Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord 네이버 미소장
10 Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development. 네이버 미소장
11 Long-term in vitro expansion alters the biology of adult mesenchymal stem cells. 네이버 미소장
12 Johnstone, B., T. M. Hering, A. I. Caplan, V. M. Goldberg and J. U. Yoo. 1998. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 238:265-272. 미소장
13 Isolation and characterization of canine adipose-derived mesenchymal stem cells. 네이버 미소장
14 Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. 네이버 미소장
15 Mesenchymal stem cells and their potential as cardiac therapeutics. 네이버 미소장
16 Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. 네이버 미소장
17 Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. 네이버 미소장
18 Spontaneous human adult stem cell transformation. 네이버 미소장
19 Alteration of gene expression levels during osteogenic induction of human adipose derived stem cells in long-term culture 네이버 미소장
20 Biotechnology in Turkey: an overview. 네이버 미소장
21 Multipotent stem cells from umbilical cord: cord is richer than blood! 네이버 미소장
22 Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells 소장
23 Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury. 네이버 미소장
24 Derivation and characterization of canine embryonic stem cell lines with in vitro and in vivo differentiation potential. 네이버 미소장
25 Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. 네이버 미소장
26 Cell Growth Characteristics and Differentiation Frequency of Adherent Equine Bone Marrow–Derived Mesenchymal Stromal Cells: Adipogenic and Osteogenic Capacity 네이버 미소장
27 Isolation, characterization, and differentiation potential of canine adipose-derived stem cells. 네이버 미소장
28 Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells. 네이버 미소장
29 Zaman, W. S., S. Makpol, S. Santhapan and K. H. Chua. 2008. Stemness gene expression profile of human adipose derived stem cells in long term culture. Med. J. Malaysia 63:61-62. 미소장
30 The effect of serial passaging on the proliferation and differentiation of bovine adipose-derived stem cells. 네이버 미소장
31 Mouse adipose-derived stem cells undergo multilineage differentiation in vitro but primarily osteogenic and chondrogenic differentiation in vivo. 네이버 미소장
32 Mesenchymal stem cells derived from canine umbilical cord vein--a novel source for cell therapy studies. 네이버 미소장
33 Multilineage cells from human adipose tissue: implications for cell-based therapies. 네이버 미소장

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