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Vitiligo is one of the most common pigmentary skin disorders; it is characterized by circumscribed depigmented macules due to the destruction of melanocytes. Although the etiology of vitiligo has not been fully elucidated, multiple factors including autoimmune and oxidative stress have been implicated in the pathogenesis of vitiligo. In contrast, dermal melanocytosis is histologically characterized by the presence of dermal melanocytes. It has been described that there are ectopic dermal melanocytes, which have failed to reach their proper location. A literature search revealed very few reports of patients with vitiligo developing vitiligo within dermal melanocytosis. Here, we report two cases of patients with vitiligo that occurred at pre-existing sites of dermal pigmented lesions. The histopathology showed the loss of epidermal melanocytes in spite of the existence of melanocytes in the dermis. There was no significant infiltration of inflammatory cells in the dermis. These cases illustrate unknown environmental factors as well as heterogeneity.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
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참고문헌 (10건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. 네이버 미소장
2 Dermal dendritic melanocytic proliferations: an update 네이버 미소장
3 Clinically distinct form of acquired dermal melanocytosis with review of published work 네이버 미소장
4 Behavior of pigment cells on lesions of the pigmented venus with vitiligo. 네이버 미소장
5 Naevus of Ota associated with segmental vitiligo: a case report 네이버 미소장
6 Increased sensitivity of melanocytes to oxidative stress and abnormal expression of tyrosinase‐related protein in vitiligo 네이버 미소장
7 Hasse S, Gibbons NC, Rokos H, Marles LK, Schallreuter KU. Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress. J Invest Dermatol 2004;122:307-313. 미소장
8 Lee AY, Kim NH, Choi WI, Youm YH. Less keratinocytederived factors related to more keratinocyte apoptosis in depigmented than normally pigmented suction-blistered epidermis may cause passive melanocyte death in vitiligo. J Invest Dermatol 2005;124:976-983. 미소장
9 Oxidative stress level and tyrosinase activity in vitiligo patients. 네이버 미소장
10 A case of giant congenital nevocytic nevus with neurotization and onset of vitiligo. 네이버 미소장