본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

This study tested the feasibility of observing H/D exchange of intact protein by top-down electron capture dissociation (ECD) mass spectrometry for the investigation of protein structure. Ubiquitin is selected as a model system. Local structural information was obtained from the deuteration levels of c and z. ions generated from ECD. Our results showed that α-helix region has the lowest deuteration level and the C-terminal fraction containing a highly mobile tail has the highest deuteration level, which correlates well with previous X-Ray and HDX/NMR analyses. We studied site-specific H/D exchange kinetics by monitoring H/D exchange rate of several structural motives of ubiquitin. Two hydrogen bonded β-strands showed similar HDX rates. However, the outer β-strand always has higher deuteration level than the inner β-strand. The HDX rate of the turn structure (residues 8-11) is lower than that of β-strands (residues 1-7 and residues 12-17) it connects. Although isotopic distribution gets broader after H/D exchange which results in a limited number of backbone cleavage sites detected, our results demonstrate that this method can provide valuable detailed structural information of proteins. This approach should also be suitable for the structural investigation of other unknown proteins, protein conformational changes, as well as protein-protein interactions and dynamics.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Synthesis of heterocyclic Baicalein derivatives Ki-Jun Hwang, Kwang-Jin Cho, Beom-Tae Kim pp.1325-1326

Au/silica/Fe₂O₃nanohybrid preparation and biosensor application Dong Kee Yi pp.1327-1328

Molecular engineering of fluorene-based photosensitizers for dye-sensitized solar cells Se-Mi Kim, Mannix P. Balanay, Sang Hee Lee, Dong Hee Kim pp.1329-1330

Synthesis, characterization, and properties of multi-walled tubular silicon nitride nanotube Bong Hyun Boo, Geun-Chang Ryu, Sukmin Kang pp.1331-1332

Chitosan nanoparticles as a new delivery system for the anti-HIV drug zidovudine El Montassir Dahmane, Mohammed Rhazi, Moha Taourirte pp.1333-1338

Synthesis of ergosterol and 5,6-dihydroergosterol glycosides and their inhibitory activities on lipopolysaccharide-induced nitric oxide production HoonGyu Park, Tae Hoon Lee, Fei Chang, Hyun Ji Kwon, Jiyoung Kim, Hakwon Kim pp.1339-1344

Nanoceramic and polytetrafluoroethylene polymer composites for mechanical seal application at low temperature A.A. Okhlopkova, S.A. Sleptsova, G.N. Alexandrov, A.E. Dedyukin, Ee Le Shim, Dae-Yong Jeong, Jin-Ho Cho pp.1345-1348

Novel 5-fluorouracil derivatives : synthesis and cytotoxic activity of 2-butoxy-4-substituted 5-fluoropyrimidines Jian Sun, Shi-Jie Zhang, Hai-Bo Li, Wei Zhou, Wei-Xiao Hu, Shang Shan pp.1349-1354

A multifunctional material based on triphenylamine and a naphthyl unit for organic light-emitting diodes, organic solar cells, and organic thin-film transistors Jongchul Kwon, Myoung Ki Kim, Jung-Pyo Hong, Woochul Lee, Seonghoon Lee, Jong-In Hong pp.1355-1360

Matrix infrared spectra and DFT computations of CH₂CNH and CH₂NCH produced from CH₃CN by laser-ablation plume radiation Han-Gook Cho pp.1361-1365

Phosphorescent iridium complexes for OLEDs based on 1-phenylpyrazole ligands with fluorine and methyl moieties Seung Soo Yoon, Ji Young Song, Eun Jae Na, Kum Hee Lee, Seong Kyu Kim, Dong Whan Lim, Seok Jae Lee, Young Kwan Kim pp.1366-1370

Chiral pool synthesis of N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine from L-malic acid Bao-Yu Hao, Jin-Qiang Liu, Wei-Han Zhang, Xin-Zhi Chen pp.1371-1377

Fluorescence enhancement of 7-diethylamino-4-methylcoumarin by noncovalent dipolar interactions with cucurbiturils Mee Ock Park, Myung Gu Moon, T.J. Kang pp.1378-1382

Influence of thiol molecular backbone structure on the formation and reductive desorption of self-assembled aromatic and alicyclic thiol monolayers on Au(111) surface Hungu Kang, Jaegeun Noh pp.1383-1387

Synthesis and characterization of new macroporous SnO₂foams Moon-Hyung Choi, Seung-Min Paek pp.1388-1390

Homogeneously dispersed silver nanoparticles on the honeycomb-patterned poly(N-vinylcarbazole)-cellulose triacetate composite thin films by the photoreduction of silver nitrate Kwang Il Kim, C. Basavaraja, Do Sung Huh pp.1391-1396

Enhanced photocatalytic activity of TiO₂modified by e-beam irradiation Moon Su Kim, Won Jun Jo, Dowon Lee, Sung-Hyeon Baeck, Joong Hyeock Shin, Byung Cheol Lee pp.1397-1400

Protein structural characterization by hydrogen/deuterium exchange mass spectrometry with top-down electron capture dissociation Hai Dong Yu, Seonghee Ahn, Byungjoo Kim pp.1401-1406

NF-κB inhibition and PPAR activation by phenolic compounds from Hypericum perforatum L. adventitious root Wei Li, Yan Ding, Tran Hong Quang, Nguyen Thi Thanh Ngan, Ya Nan Sun, Xi Tao Yan, Seo Young Yang, Chun Whan Choi, Eun Jung Lee, Kee Yoeup Paek … [et al.] pp.1407-1413

Synthesis of new spiro[benzo[c]fluorene-7,9'-fluorene] dimers and their optical properties Jeong-A Seo, Chil-Won Lee, Myoung-Seon Gong pp.1414-1420

Cytotoxic isoflavanones from Uraria clarkei Xiang-Zhong Huang, Xi-Shan Bai, Hui Liang, Chao Wang, Wen-Juan Li, Jun-Ming Guo, Zhi-Yong Jiang pp.1421-1424

Salinosporamides A and B inhibit proteasome activity and delay the degradation of N-end rule model substrates Seung Kyun Shin, Dae in Bang, Won Hoon Choi, Seong-Hwan Kim, Dong-Chan Oh, Min Jae Lee pp.1425-1428

A carbazole-attached NO₂S₂-macrocycle exhibiting Hg^2+^ and Cu^2+^ selectivity Seul-Gi Lee, Eun-Ju Kang, Shim Sung Lee pp.1429-1434

Effect of carbon matrix on electrochemical performance of Si/C composites for use in anodes of lithium secondary batteries Eun Hee Lee, Bo Ock Jeong, Seong Hun Jeong, Tae Jeong Kim, Yong Shin Kim, Yongju Jung pp.1435-1440

Anion photoelectron spectroscopy and theoretical calculation of the hetero-dimers of polycyclic aromatic hydrocarbons Namdoo Kim, Sang Hak Lee pp.1441-1444

Synthesis and characterization of Zn_(1-x)_Ni_x_Al₂O₄spinels as a new heterogeneous catalyst of Biginelli's reaction Fatima-Zohra Akika, Nadjib Kihal, Tahir Habila, Ivalina Avramova, Şefik Suzer, Bernard Pirotte, Smail Khelili pp.1445-1453

Point particle approximation for single and two species diffusion-influenced reactions Hyojoon Kim pp.1454-1456

Synthesis of composite particles with Fe₃O₄core and Ag shell for the development of fingerprints Ling-Yan Zhang, Ting Chu pp.1457-1461

Template-assisted electrochemical growth of hydrous ruthenium oxide nanotubes Sanghyun Cho, Lichun Liu, Sang-Hoon Yoo, Ho-Young Jang, Sungho Park pp.1462-1466

Study of metabolic profiling changes in colorectal cancer tissues using 1D ¹H HR-MAS NMR spectroscopy Siwon Kim, Sangmi Lee, Young Hee Maeng, Weon Young Chang, Jin Won Hyun, Suhkmann Kim pp.1467-1472

Effect of soft-annealing on the properties of CIGSe thin films prepared from solution precursors Shi-Joon Sung, Mi Sun Park, Dae-Hwan Kim, Jin-Kyu Kang pp.1473-1476

Heterogeneous Suzuki cross-coupling reaction catalyzed by magnetically recyclable nanocatalyst Kwang-Hyun Choi, Mohammadreza Shokouhimehr, Yung-Eun Sung pp.1477-1480

Bifunctional Fe-SBA-15-SO₃H mesoporous catalysts with different Si/Fe molar ratios : synthesis, characterization and catalytic activity Sezer Erdem, Beyhan Erdem, Ramis Mustafa Öksüzoğlu, Alime Çıtak pp.1481-1486

Synthesis of novel N-(2-hydroxyphenyl)arylsulfonamides as selective HDAC inhibitory and cytotoxic agents Jungsu Kim, Pusoon Chun, Hyung Ryong Moon pp.1487-1493

Energy flow and bond dissociation of vibrationally excited toluene in collisions with N₂and O₂ Jongbaik Ree, Sung Hee Kim, Sang Kwon Lee pp.1494-1502

Hsp27 reduces phosphorylated tau and prevents cell death in the human neuroblastoma cell line SH-SY5Y Junseong Ahn, Hyeseon Kim, Jong-Sang Park pp.1503-1507

A fast, highly efficient and green protocol for one-pot synthesis of 2,4,5-trisubstituted imidazoles catalyzed by [TBA]₂[W_6_O_19_] as a reusable heterogeneous catalyst Mozhgan Ashrafi, Abolghasem Davoodnia, Niloofar Tavakoli-Hoseini pp.1508-1512

Development of thiourea-formaldehyde crosslinked chitosan membrane networks for separation of Cu(Ⅱ) and Ni(Ⅱ) ions T.J. Sudhavani, N. Sivagangi Reddy, K. Madhusudana Rao, K.S.V. Krishna Rao, Jayshree Ramkumar, A.V.R. Reddy pp.1513-1520

Magnetic nanoparticle immobilized N-propylsulfamic acid as a recyclable and efficient nanocatalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones in solvent-free conditions : comparison with sulfamic acid Amin Rostami, Bahman Tahmasbi, Ako Yari pp.1521-1524

Metal-ion catalysis in alkaline ethanolysis of 2-pyridyl thionobenzoate : effects of modification of electrophilic center from C=O to C=S Ik-Hwan Um, Yoon-Ju Song, Min-Young Kim, Jae-In Lee pp.1525-1529

Fluorescence chemosensor for fluoride anion with coumarin bipyridine derivative Sung Won Hong, Nam Joong Jeon, Jumi Jeong, Juhyun Hong, Kye Chun Nam pp.1530-1532

Molecular engineering of carbazole dyes for efficient dye-sensitized solar cells Jungeun Park, Eunji Lee, Jinho Kim, Youngjin Kang pp.1533-1536

A base promoted synthesis of N,N-dimethylformamidines Bao Lin Li, Si Yi Ding, Yu Fei Ren, Liu Chang Wang, Yu Cai Jia, Xi Quan Zhang, Hong Mei Gu pp.1537-1540

A new cassane-type diterpene and other constituents from Caesalpinia minax Huiling Liu, Guoxu Ma, Jingquan Yuan, Xiaoming Tan, Qingxia Zheng, Zhaocui Sun, Junshan Yang, Xudong Xu pp.1541-1542

Synthesis and color modulation of an unsymmetrical calix[4]-bis-crown incorporating p-nitro-azobenzene as a chromoionophoric mixed receptor Hwan Gyu Lee, Joobeom Seo, Kyu Seong Choi pp.1543-1546

Phosphorescence properties of neat FIrpic films Noh Soo Han, So Hyeong Sohn, Seung Min Park, Jae Kyu Song pp.1547-1550

Theoretical investigation of the reaction of Ce^+^ with water in the gas phase : density functional theory calculations Kiryong Hong, Joonghan Kim, Tae Kyu Kim pp.1551-1554

Chemical constituents of the Morinda tomentosa leaves and their α-glucosidase inhibitory activity Vu Huong Giang, Ninh Khac Ban, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Hoang Le Tuan Anh, Pham Hai Yen, Bui Huu Tai, Nguyen Xuan Cuong, Nguyen Hoai Nam … [et al.] pp.1555-1558

Comparative pharmacokinetics of berberine after oral administration of pure berberine, Coptidis Rhizoma extract, and Decoctions of two different complex herbal formulas to rats Jianbo Chen, Xitao Yan, Kyung Tae Kim, Sang Hyuck Kim, Eun-Sil Lee, Young Keun Lee, Chang Gyu Son, Eun Hee Lee, Yong Ki Park, Cheong Weon Cho … [et al.] pp.1559-1562

Unsymmetrically substituted leuco-triarylmethane molecules formed from the reaction of a Fischer's base and α,β-unsaturated iminium salts via a Michael-type reaction Sam-Rok Keum, Hyun-Soo Kim, Do-Kyung Kim pp.1563-1566

Fabrication of superhydrophobic conical structures of polysiloxane on Mg plates using an immersion process Seungcheol Go, Younga Kim, Yonghyun Ahn pp.1567-1570

Method optimization for rapid measurement of carbohydrates in plasma by liquid chromatography tandem mass spectrometry Duc-Toan Nguyen, Jundong Yu, Sun-Il Mho, Hae-Lee Lee, Wonjae Lee, Sung-Tae Yee, Gwang Lee, Man-Jeong Paik pp.1571-1574

Preparation 2-substituted-4-pyridylzinc bromides via direct insertion of active zinc and their coupling reactions Ueon Sang Shin, Kyung-Hwan Cho, Seung-Hoi Kim pp.1575-1578

Lithium containing rare-earth metal germanide, Er_3.93_Li_1.07_Ge₄ : synthesis, crystal structure and chemical bonding Gnu Nam, Beom Yong Jeon, Youngjo Kim, Sung Kwon Kang, Tae-Soo You pp.1579-1582

Anthracene dicarboxylate-based metal-organic framework gel with Zn^2+^ as a TNT sensor Sung Ho Jung, Hyejin Lee, Moo Lyong Seo, Jong Hwa Jung pp.1583-1585

A method for improving the optical properties of a fluoregenic Di-metal chelator as a Zn^2+^ ion fluorescent probe by using a bridging substrate Min Sik Eom, Han Saem Park, Sudeok Kim, Kyungkyu Baek, Sang Yeob Ahn, Seok Keun Choi, Min Su Han pp.1586-1588

Two new ent-kaurane diterpenoids from the roots of Fritillaria thunbergii Jong Eel Park, Seung Young Lee, Kyeong Wan Woo, Je Hyun Lee, Kang Ro Lee pp.1589-1591

New and efficient synthesis of amides from acid chlorides using diisobutyl(amino)aluminum Jae Kyo Park, Won Kyu Shin, Duk Keun An pp.1592-1594

참고문헌 (55건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Garcia, R. A.; Pantazatos, D.; Villarreal, F. J. ASSAY and Drug Development Technologies 2004, 2, 81-91. 미소장
2 Protein Science as an international journal 네이버 미소장
3 Kragelund, B. B.; Robinson, C. V.; Knudsen, J.; Dobson, C. M.; Poulsen, F. M. Biochemistry 1995, 34, 7217-7224. 미소장
4 Wales, T. E.; Engen, J. R. Mass Spectrometry Reviews 2006, 25, 158-170. 미소장
5 Mass spectrometry of very large saturated hydrocarbons 네이버 미소장
6 Krishna, M. M. G.; Hoang, L.; Lin, Y.; Englander, S. W. Methods 2004, 34, 51-64. 미소장
7 Uzawa, T.; Nishimura, C.; Akiyama, S.; Ishimori, K.; Takahashi, S.; Dyson, H. J.; Wright, P. E. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 13859-13864. 미소장
8 Kuwata, K.; Shastry, R.; Cheng, H.; Hoshino, M.; Batt, C. A.; Goto, Y.; Roder, H. Nat. Struct. Biol. 2001, 8, 151-155. 미소장
9 Roder, H.; Elove, G. A.; Englander, S. W. Nature 1988, 335, 700-704. 미소장
10 Udgaonkar, J. B.; Baldwin, R. L. Nature 1988, 335, 694-699. 미소장
11 Biochemistry of inflammatory processes and vascular injury. Role of neutrophils: a review. 네이버 미소장
12 Bai, Y.; Sosnick, T. R.; Mayne, L.; Englander, S. W. Science 1995, 269, 192-197. 미소장
13 Carulla, N.; Barany, G.; Woodward, C. Biophys. Chem. 2002, 101- 102, 67-79. 미소장
14 Parker, M. J.; Marqusee, S. J. Mol. Biol. 2001, 305, 593-602. 미소장
15 Pan, Y.; Briggs, M. S. Biochemistry 1992, 31, 11405-11412. 미소장
16 Bougault, C.; Feng, L.; Glushka, J.; Kupce, E.; Prestegard, J. H. J. Biomol. NMR 2004, 28, 385-390. 미소장
17 Dyson, H. J.; Wright, P. E. Chem. Rev. 2004, 104, 3607-3622. 미소장
18 Yu, H. Proc. Natl. Acad. Sci. USA. 1999, 96, 332-334. 미소장
19 Katta, V.; Chait, B. T. J. Am. Chem. Soc. 1993, 115, 6317-6321. 미소장
20 Mass spectrometry, carbon clusters and coal 네이버 미소장
21 Akashi, S.; Naito, Y.; Takio, K. Anal. Chem. 1999, 71, 4974-4980. 미소장
22 Deng, Y.; Pan, H.; Smith, D. L. J. Am. Chem. Soc. 1999, 121, 1966- 1967. 미소장
23 Kim, M.-Y.; Maier, C. S.; Reed, D. J.; Deinzer, M. L. J. Am. Chem. Soc. 2001, 123, 9860-9866. 미소장
24 Demmers, J. A. A.; Rijkers, D. T. S.; Haverkamp, J.; Killian, J. A.; Heck, A. J. R. J. Am. Chem. Soc. 2002, 124, 11191-11198. 미소장
25 Mass spectrometric investigation of gaseous YbH, YbO and YbOH molecules 네이버 미소장
26 Jørgensen, T. J. D.; Gårdsvoll, H.; Ploug, M.; Roepstorff, P. J. Am. Chem. Soc. 2005, 127, 2785-2793. 미소장
27 Ferguson, P. L.; Pan, J.; Wilson, D. J.; Dempsey, B.; Lajoie, G.; Shilton, B.; Konermann, L. Anal. Chem. 2007, 79, 153-160. 미소장
28 Ferguson, P. L.; Konermann, L. Anal. Chem. 2008, 80, 4078-4086. 미소장
29 McLafferty, F. W.; Guan, Z.; Haupts, U.; Wood, T. D.; Kelleher, N. L. J. Am. Chem. Soc. 1998, 120, 4732-4740. 미소장
30 Polfer, N. C. Chem. Soc. Rev. 2011, 40, 2211-2221. 미소장
31 Mass spectrometric study of oligourea macrocycles and their anion binding behavior. 네이버 미소장
32 Mass spectrometric analysis of hydroxyproline glycans 네이버 미소장
33 Gauthier, J. W.; Trautman, T. R.; Jacobson, D. B. Anal. Chim. Acta 1991, 246, 211-225. 미소장
34 Mass spectrometry of rhenium complexes: a comparative study by using LDI-MS, MALDI-MS, PESI-MS and ESI-MS. 네이버 미소장
35 Barrow, M. P.; Burkitt, W. I.; Derrick, P. J. Analyst 2005, 130, 18-28. 미소장
36 Zubarev, R. A.; Kelleher, N. L.; McLafferty, F. W. J. Am. Chem. Soc. 1998, 120, 3265-3266. 미소장
37 Kleinnijenhuis, A. J.; Duursma, M. C.; Breukink, E.; Heeren, R. M. A.; Heck, A. J. R. Anal. Chem. 2003, 75, 3219-3225. 미소장
38 Breuker, K.; Oh, H.; Lin, C.; Carpenter, B. K.; McLafferty, F. W. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 14011-14016. 미소장
39 Rand, K. D.; Adams, C. M.; Zubarev, R. A.; Jørgensen, T. J. D. J. Am. Chem. Soc. 2008, 130, 1341-1349. 미소장
40 Ge, Y.; Lawhorn, B. G.; EINaggar, M.; Strauss, E.; Park, J.-H.; Begley, T. P.; McLafferty, F. W. J. Am. Chem. Soc. 2002, 124, 672-678. 미소장
41 Mass spectrometric characterization of lipid‐modified peptides for the analysis of acylated proteins 네이버 미소장
42 Charlebois, J. P.; Patrie, S. M.; Kelleher, N. L. Anal. Chem. 2003, 75, 3263-3266. 미소장
43 Pan, J.; Han, J.; Borchers, C. H.; Konermann, L. J. Am. Chem. Soc. 2009, 131, 12801-12808. 미소장
44 Pan, J.; Han, J.; Borchers, C. H.; Konermann, L. J. Am. Chem. Soc. 2008, 130, 11574-11575. 미소장
45 Zehl, M.; Rand, K. D.; Jensen, O. N.; Jørgensen, T. J. D. J. Am. Chem. Soc. 2008, 130, 17453-17459. 미소장
46 Sterling, H. J.; Williams, E. R. Anal. Chem. 2010, 82, 9050-9057. 미소장
47 Rand, K. D.; Pringle, S. D.; Morris, M.; Brown, J. M. Anal. Chem. 2012, 84, 1931-1940. 미소장
48 Vijay-Kumar, S.; Bugg, C. E.; Cook, W. J. J. Mol. Biol. 1987, 194, 531-544. 미소장
49 Vijay-Kumar, S.; Bugg, C. E.; Wilkinson, K. D.; Cook, W. J. Proc. Natl. Acad. Sci. U. S. A. 1985, 82, 3582-3585. 미소장
50 Briggs, M. S.; Roder, H. Proc. Natl. Acad. Sci. U. S. A. 1992, 89, 2017-2021. 미소장
51 Biochemistry of terminal deoxynucleotidyltransferase (TdT): characterization and mechanism of inhibition of TdT by P1, P5-bis(5'-adenosyl) pentaphosphate. 네이버 미소장
52 Protein Science welcomes new publisher 네이버 미소장
53 Mohimen, A.; Dobo, A.; Hoerner, J. K.; Kaltashov, I. A. Anal. Chem. 2003, 75, 4139-4147. 미소장
54 iu, Z.; Cheng, S.; Gallie, D. R.; Julian, R. R. Anal. Chem. 2008, 80, 3846-3852. 미소장
55 Image from the RCSB PDB (www.pdb.org) of PDB ID 1UBI: Ramage, R.; Green, J.; Muir, T. W.; Ogunjobi, O. M.; Love, S.; Shaw, K. Biochem. J. 1994, 299, 151-158. 미소장

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기