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Uridine diphosphoglucuronosyltransferases (UGTs) are a superfamily of enzymes that catalyze the glucuronidation of xenobiotics and endobiotics. To reveal occurrence of UGT1A polymorphisms, we retrospectively aimed to characterize UGT1A1-UGT1A9 haplotype structures in Koreans and gain insight on their association with increased cancer incidence. We genotyped UGT1A1 (-3279T>G, -3156G>A, -53(TA)6>7, 211G>A and 686C>A), and UGT1A9 (-2152C>T, -275T>A and -118T9>10) variants by direct sequencing in 98 lung cancer patients and 154 healthy subjects. The haplotype structure across the UGT1A locus was constituted using 4 haplotype-tagging SNPs (htSNPs). For polymorphisms in UGT1A1 and UGT1A9, no significant differences in allele frequency were found between the two groups. The strongest linkage disequilibrium (LD) was discovered between UGT1A1 -53(TA)6>7 and 211G>A, and lowest LD was observed between the UGT1A1 -53(TA)6>7 and UGT1A9 -118T9>10 variant. Eight UGT1A1-UGT1A9 haplotypes were provided and the three most common haplotypes were D-T-6-G, N-T-6-A, and N-G-6-G (73% of all haplotypes) in two groups. Ultimately, no significant differences exist in haplotype frequency between cases and controls (likelihood ratio statistic 20.06, df = 15, p = 0.08). Logistic regression analysis presented a statistically significant association between UGT1A1-UGT1A9 diplotypes including 4 minor alleles and increased lung cancer incidence (OR 31.32, 95% CI 4.34-226.23). There was statistically significant difference in the distribution of the UGT1A1 and UGT1A9 diplotype frequency between cases and controls. These results suggest that the diplotype in the UGT1A1 and UGT1A9 gene might be associated with an increased risk for lung cancer among Korean.

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기사명 저자명 페이지 원문 목차
보건통계학 교육시 R의 활용에 대한 연구. 1 이태림, 장대흥 pp.1-28

대구일 종합병원 전자간호기록 시스템에 대한 사용자 만족도 조사 신아미, 박희준, 정선주, 박명화, 윤경일, 김윤년 pp.29-39

The diplotype of UGT1A1 and UGT1A9 genes may predict an increased risk for lung cancer Jung Ran Choi, Dae Ryong Kang, Jeong-Oh Kim, In Kyung Kim, Hyun Suk Chae, Jin-Hyoung Kang pp.41-51

양적 형질의 유전적 관련성 연구에서 치료 효과를 보정하기 위한 통계학적 방법의 비교 한경화, 임길섭, 박성하, 장양수, 송기준 pp.53-62

일부 지역 치과위생사들의 삶의 질과 직업만족도 박지혜, 조미숙 pp.63-71

유전자료를 이용한 악성 간암환자 나무구조 생존예측 모형연구 이태림, 이효석 pp.73-83

참고문헌 (21건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38. 네이버 미소장
2 Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk. 네이버 미소장
3 Dellinger RW, Fang JL, Chen G, Weinberg R, Lazarus P. Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139LYS isoform. Drug Metab Dispos 2006;34:943-9. 미소장
4 Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. 네이버 미소장
5 Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer. 네이버 미소장
6 Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan. 네이버 미소장
7 Sandanaraj E, Jada SR, Shu X, Lim R, Lee SC, Zhou Q, Zhou S, Goh BC, Chowbay B. Influence of UGT1A9 intronic 1399C>T polymorphism on SN-38 glucuronidation in Asian cancer patients. Pharmacogenomics J 2008; 8:174-185. 미소장
8 Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. 네이버 미소장
9 UGT pharmacogenomics: implications for cancer risk and cancer therapeutics. 네이버 미소장
10 Haplotype structures of the UGT1A gene complex in a Japanese population 네이버 미소장
11 A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity. 네이버 미소장
12 Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus. 네이버 미소장
13 A Comparison of Linkage Disequilibrium Measures for Fine-Scale Mapping 네이버 미소장
14 Zhao JH, Curtis D, Sham PC. Model-free analysis and permutaion tests for allelic associations Hum Hered 2000;50:133-9. 미소장
15 Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes. 네이버 미소장
16 Adegoke OJ, Shu XO, Gao YT, Cai Q, Breyer J, Smith J, Zheng W. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer. Breast Cancer Res Treat 200485:239-45. 미소장
17 Genetic polymorphisms in the UGT1A1 gene and breast cancer risk in Greek women. 네이버 미소장
18 Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans. 네이버 미소장
19 Tang KS, ChiuHF, Chen HH, Eng HL, Tsai CJ, Teng HC, Huang CS. Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. World J Gastroenterol 2005;11:3250-4. 미소장
20 Polymorphism of UDP-glucuronosyltransferase 1A7 gene: A possible new risk factor for lung cancer 네이버 미소장
21 CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. 네이버 미소장

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