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Liver regeneration is a process involving highly organized and ordered tissue growth triggered by the loss of liver tissue. This process has remained a fascinating topic in medicine. In this study, we examined the effects of recombinant human interleukin-2 (rhIL-2) in rats under cirrhotic conditions. Thirty rats were divided into three groups, and liver cirrhosis was induced by injecting diethylnitrosamine for 2 weeks and CCl4 for 8 weeks. After induction of cirrhosis, rhIL-2 was injected daily into their tail vein for three days and then hepatocyte growth factor (HGF), immunocytes in the blood, and TNF-a production were analyzed. The analysis showed that TNF-a was significantly downregulated in the liver without significant changes in nitric oxide and caspase-3/7 activities in primary cultured liver cells. In terms of the number of immunocytes, there were no significant differences between the control and the treated groups. However, HGF levels were significantly higher in the treated groups than the control (saline administration) group. Treatment of rhIL-2 significantly increased the proliferation of primary cultured liver cells. The proliferation rates of primary cultured liver cells were correlated with the upregulation of HGF by treatment with rhIL-2 in vivo and in vitro. These results suggest that rhIL-2 affects liver regeneration, which is at least related to the upregulation of HGF under cirrhotic conditions in rats.

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Comparative study on the differential mechanical properties of human liver cancer and normal cells Yeongjin Kim, Jung Woo Hong, Jung Kim, Jennifer H. Shin pp.170-178

Administration of rhIL-2 upregulates HGF in the cirrhotic liver of partial hepatectomized rats Miae Jeon, Hyun-Jung Kwon, Yong Hyun Kim, Kook-il Han, Kung-Woo Nam, Yeongjun Baik, Sunghee Lee, Wan-Jong Kim, Man-Deuk Han pp.179-185

Phosphorylation of human chromosome maintenance 1 mediates association with 14-3-3 proteins Sang Sun Kang, Sung Hwa Shin pp.186-195

Comparison between different combinations of chemical treatment on parthenogenetic activation of mouse oocytes and its subsequent embryonic development Siti Khadijah Idris, Ramli Bin Abdullah, Wan Khadijah Wan Embong, Mohammad Mijanur Rahman pp.196-202

Molecular characterization of four actin cDNAs and effects of 20-hydroxyecdysone on their expression in swimming crab, Portunus trituberculatus(Miers, 1876) Md. Hasan Uddowla, Umme Salma, Hyun-Woo Kim pp.203-212

Habitat-specific variation in stable C and N isotope ratios of pond smelt(Hypomesus nipponensis) Jae-Yong Lee, Jaeseok Choi, Jeffrey S. Owen, Kwangyeol Lee, Woomyung Heo, Bomchul Kim pp.213-219

참고문헌 (29건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Met Provides Essential Signals for Liver Regeneration 네이버 미소장
2 Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. 네이버 미소장
3 HSCs play a distinct role in different phases of oval cell‐mediated liver regeneration 네이버 미소장
4 Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. 네이버 미소장
5 Hepatocyte Growth Factor Exerts Its Anti-Inflammatory Action by Disrupting Nuclear Factor- kappa B Signaling 네이버 미소장
6 Multi-target anti-inflammatory action of hepatocyte growth factor. 네이버 미소장
7 The Effect of Hepatocyte Growth Factor on the Initiation Phase of Liver Regeneration after Cold Ischemia in a Rat Model of Small-For-Size Liver Transplantation 네이버 미소장
8 Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway. 네이버 미소장
9 Hepatocyte Growth Factor Suppresses Profibrogenic Signal Transduction via Nuclear Export of Smad3 With Galectin-7 네이버 미소장
10 Relationship between the proliferative capability of hepatocytes and the intrahepatic expression of hepatocyte growth factor and c-Met in the course of cirrhosis development in rats. 네이버 미소장
11 Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice. 네이버 미소장
12 Hepatocyte Growth Factor Stimulates Liver Regeneration and Elevates Blood Protein Level in Normal and Partially Hepatectomized Rats. 네이버 미소장
13 Hepatocyte growth factor/c‐met signaling is required for stem‐cell–mediated liver regeneration in mice 네이버 미소장
14 Advances in the regulation of liver regeneration. 네이버 미소장
15 HGF suppresses the production of collagen type III and alpha-SMA induced by TGF-beta1 in healing fibroblasts. 네이버 미소장
16 Growth Inhibition and Apoptosis in Liver Myofibroblasts Promoted by Hepatocyte Growth Factor Leads to Resolution from Liver Cirrhosis 네이버 미소장
17 Effect of hepatocyte growth factor encapsulated in targeted liposomes on liver cirrhosis 네이버 미소장
18 Isolation and primary culture of rat hepatocytes. 네이버 미소장
19 Inhibition of inducible nitric oxide synthase activity prevents liver recovery in rat thioacetamide-induced fibrosis reversal. 네이버 미소장
20 Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regeneration. 네이버 미소장
21 The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine. 네이버 미소장
22 Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta. 네이버 미소장
23 Hepatocyte growth factor improves survival after partial hepatectomy in cirrhotic rats suppressing apoptosis of hepatocytes 네이버 미소장
24 The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced by thioacetamide 네이버 미소장
25 Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue 네이버 미소장
26 Induction of HGF and VEGF in Hepatic Regeneration after Hepatotoxin-Induced Cirrhosis in Mice 네이버 미소장
27 Interleukin-2 overexpresses c-myc and down-regulates cytochrome P-450 in rat hepatocytes. 네이버 미소장
28 Liver fibrosis. 네이버 미소장
29 Executioner Caspase-3 and Caspase-7 Are Functionally Distinct Proteases 네이버 미소장

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