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한국학술지인용색인(NRF)
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국회도서관 홈으로
정보검색
소장정보 검색
결과 내 검색
동의어 포함
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배경 및 목적：돼지의 관상동맥 재협착 모형에서 일반 금속 스텐트(baremetal stent, BMS)와 약물 용출 스텐트(drug-eluting stent,DES)를 각각 중첩하였을 경우 조직반응과 신생내막 증식에 미치는 영향을 알고자 하였다. 방 법：돼지의 좌전하행지 근위부에 스텐트를 삽입한 후 다른 스텐트를 중첩시켜 삽입하였으며, 중첩부위에 추가적으로 풍선을 확장시켰다. 1군(n=10)은 10개의 BMS를 동일한 10개의 BMS에 중첩시켰으며, 2군(n=10)은 10개의 sirolimuselutingstent(SES)를 동일한 10개의 SES에, 3군(n=10)은10개의 paclitaxel-eluting stent(PES)를 동일한 10개의 PES에, 4군(n=10)은 10개의 SES를 다른 10개의 PES에 각각중첩시켰다. 4주 후에 추적 관상동맥 조영술을 시행한 후, 돼지를 희생시켜, 스텐트를 함유하고 있는 관상동맥을 분리, 관류고정한 후 조직병리 관찰 및 측정을 시행하였다. 결 과：스텐트 시술 4주 후 중첩부위의 최소 내경면적은 I군 1.78±0.13 mm, II군 2.79±0.09 mm, III군 2.90±0.04 mm, IV군 2.80±0.07 mm로서 I군에서 유의하게 컸다(p<0.001).조직형태학적 검사에서 중첩부위의 신생내막 면적은 I군 5.51±0.58 mm2, II군 2.38±0.53 mm2, III군 2.07±0.37 mm2, IV군 2.39±0.58 mm2로서 I군에서 유의하게 넓었으며(p<0.001), 면적협착은 I군 68.74±4.02%, II군 27.79±4.73%,III군 23.66±3.24%, IV군 27.63±4.07%로서 I군에서 면적협착이 유의하게 컸다(p<0.001). 중첩부위의 신생내막의 염증세포 침윤지수는 Ⅰ군 1.80±0.42, II군 2.10±0.32, III군 2.90±0.31, IV군 2.50±0.52로서 III군에서 유의하게 높았으며(p<0.001), 내피화지수는 Ⅰ군 2.80±0.42, II군2.30±0.67, III군 1.30±0.48, IV군 2.10±0.74으로서 III군에서 유의하게 낮았다(p<0.001).결 론：DES를 중첩시술 하였을 때 BMS의 중첩시술에 비해 재협착을 효과적으로 억제할 수 있었다, 중첩부위의 심한 염증으로 인한 내피화의 장애를 보였고 PES를 중첩하였을 때 더욱 심하였다.
Background and Objectives：This study was conducted to evaluate the inflammatory reaction at sites of overlappingstents in a porcine in-stent restenosis (ISR) model. Materials and Methods：Twenty bare metal stents(BMS, Group I; n=10), 20 sirolimus-eluting stents (SES, Group II; n=10), 20 paclitaxel-eluting stents (PES,Group III; n=10), 10 PESs and 10 SESs (Group IV; n=10) were deployed and overlapped in the left anteriordescending coronary arteries of 40 pigs. Follow-up coronary angiograms and histopathologic analysis were performedat 4 weeks after stenting. Results：The minimal luminal diameter of the overlapped segment at 4 weekswas smaller in group I than that in the other groups (1.78±0.13 mm vs. 2.79±0.09 mm vs. 2.90±0.04 mm vs.2.80±0.07 mm, respectively, p<0.001). The neointimal area (5.51±0.58 mm2 vs. 2.38±0.53 mm2 vs. 2.07±0.37 mm2 vs. 2.39±0.58 mm2, respectively, p<0.001) and the area stenosis (68.74±4.02% vs. 27.79±4.73% vs.23.66±3.24% vs. 27.63±4.07%, respectively, p<0.001) of the overlapped segment were significantly higher inGroup I than that in the other groups. The inflammatory score of the overlapped segment was significantlyhigher in Group III than that in the other groups (1.80±0.42 vs. 2.10±0.32 vs. 2.90±0.31 vs. 2.50±0.52, respectively,p<0.001). The endothelization score of the overlapped segment was significantly lower in Group IIIthan that in the other groups (2.80±0.42 vs. 2.30±0.67 vs. 1.30±0.48 vs. 2.10±0.74, respectively, p<0.001).Conclusion：Compared with the BMS, the DES inhibits neointimal hyperplasia, but inflammation and poorendothelization are observed at the sites of overlapped stents.
Background and Objectives：This study was conducted to evaluate the inflammatory reaction at sites of overlappingstents in a porcine in-stent restenosis (ISR) model. Materials and Methods：Twenty bare metal stents(BMS, Group I; n=10), 20 sirolimus-eluting stents (SES, Group II; n=10), 20 paclitaxel-eluting stents (PES,Group III; n=10), 10 PESs and 10 SESs (Group IV; n=10) were deployed and overlapped in the left anteriordescending coronary arteries of 40 pigs. Follow-up coronary angiograms and histopathologic analysis were performedat 4 weeks after stenting. Results：The minimal luminal diameter of the overlapped segment at 4 weekswas smaller in group I than that in the other groups (1.78±0.13 mm vs. 2.79±0.09 mm vs. 2.90±0.04 mm vs.2.80±0.07 mm, respectively, p<0.001). The neointimal area (5.51±0.58 mm2 vs. 2.38±0.53 mm2 vs. 2.07±0.37 mm2 vs. 2.39±0.58 mm2, respectively, p<0.001) and the area stenosis (68.74±4.02% vs. 27.79±4.73% vs.23.66±3.24% vs. 27.63±4.07%, respectively, p<0.001) of the overlapped segment were significantly higher inGroup I than that in the other groups. The inflammatory score of the overlapped segment was significantlyhigher in Group III than that in the other groups (1.80±0.42 vs. 2.10±0.32 vs. 2.90±0.31 vs. 2.50±0.52, respectively,p<0.001). The endothelization score of the overlapped segment was significantly lower in Group IIIthan that in the other groups (2.80±0.42 vs. 2.30±0.67 vs. 1.30±0.48 vs. 2.10±0.74, respectively, p<0.001).Conclusion：Compared with the BMS, the DES inhibits neointimal hyperplasia, but inflammation and poorendothelization are observed at the sites of overlapped stents.
권호기사
참고문헌 (30건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
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| 6 | Finn AV, (2005) Differential response ofdelayed healing and persistent inflammation at sites of overlappingsirolimus- or paclitaxel-eluting stents, | 미소장 |
| 7 | Ahn YK, (1999) Preventive effects of heparincoated stent on restenosis in the porcine model, | 미소장 |
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