대표어
한국학술지인용색인(NRF)
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The aim of this study was to improve dissolution rate and controlled release of poorly water-soluble drug, cilostazol, using general water soluble polymers. We prepared solid dispersed cilostazol with hydrophilic polymer, Poly-N-Vinylpyrolidone(PVP), Plasdone S630, Hydroxypropylmethylcellulose(HPMC), PEG 6000, Eudragit E100, and surfactant, Poloxamer 407. Characterization of cilostazol solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and infrared spectrometry(FT-IR). SEM and DSC were found that amorphous in solid dispersion. Particle size analyzer was used to investigate size of cilostazol in solid dispersion. The in vitro release behavior of solid dispersion presented at simulated gastric fluid(pH 1.2). The release behavior of cilostazol was controlled release with hydrophilic polymers and solid dispersed cilostazol with hydrophilic polymers was sustained release behavior than initial burst release of commercial drug(Pletal?. This studies suggest that this solid dispersion system with hydrophilic polymers controlled poorly water-soluble drug, cilostazol,
release behaviors.권호기사
참고문헌 (34건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | JW Park, KH Shin, MJ Kwon, et al., Controlled release preparation containing cilostazol and process for the preparation thereof, Korea Patent, 10-2008-0076440 (2008). | 미소장 |
| 2 | In vitro–in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol  |
미소장 |
| 3 | Method for the quantitative analysis of cilostazol and its metabolites in human plasma using LC/MS/MS |
미소장 |
| 4 | Physico-chemical properties and stability of cilostazol. |
미소장 |
| 5 | SL Bramer, WP Forbes, Relative bioavailability and effect of a high fat metal on single dose cilostazol pharmacokinetics, Pharmacokinetics, 37, 13 (1999). | 미소장 |
| 6 | Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs. |
미소장 |
| 7 | JH Lee, J Ku, YH Lee, et al., Recent advances of improvement of bioavailability for poorly water soluble drugs by solid dispersions, Tissue Eng Regen Med, 6, 43 (2009). | 미소장 |
| 8 | SW Park, JH Lee, DS Kim, et al., Improvement of dissolution property of pranlukast by nano-solid dispersion with poly(nvinylpyrrolidone), Tissue Eng Regen Med, 5, 600 (2008). | 미소장 |
| 9 | Improving drug solubility for oral delivery using solid dispersions |
미소장 |
| 10 | R Chaderi, P Artursson, J Carlfors, Preparation of biodegradable microparticles using solution-enhanced dispersion by supercritical fluids(SEDS), Pharm Res, 16, 676 (1999). | 미소장 |
| 11 | LS Tayor, G Zografi, Spectroscopic characterization of interactions between PVP and indomethacin in amophous molecular dispersions, Pharm Res, 14, 1691 (1997). | 미소장 |
| 12 | Crystallization of indomethacin from the amorphous state below and above its glass transition temperature. |
미소장 |
| 13 | Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques. |
미소장 |
| 14 | Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics. |
미소장 |
| 15 | S Hasegawa, T Hamaura, N Furuyama, et al., Effects of water content in pysical mixture and heating temperature on crystaillinity of troglitazone-PVP K30 solid dispersions prepared by closed melting method, Int J Parm, 302, 103 (2005). | 미소장 |
| 16 | Novel lipid-based formulations enhancing the in vitro dissolution and permeability characteristics of a poorly water-soluble model drug, piroxicam |
미소장 |
| 17 | Physicochemical characterization and dissolution of norfloxacin/cyclodextrin inclusion compounds and PEG solid dispersions |
미소장 |
| 18 | Thermodynamic properties for the system of silybin and poly(ethylene glycol) 6000 |
미소장 |
| 19 | JH Lee, J Ku, JS Park, et al., Improved dissolution and characterization of solid dispersed atorvastatin calcium, J Kor Pharm Sci, 38, 111 (2008). | 미소장 |
| 20 | A Ceblllos, M Cirri, F Maestrelli, et al., Influence of formulation and process variables on in vitro release of theophylline form directly-compressed eudragit matrix tablets, Farmaco, 60, 913 (2005). | 미소장 |
| 21 | Nifedipine solid dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend for controlled drug delivery: Effect of drug loading on release kinetics |
미소장 |
| 22 | Dissolution rates of high energy polyvinylpyrrolidone (PVP)-sulfathiazole coprecipitates. |
미소장 |
| 23 | Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics. |
미소장 |
| 24 | A three step supercritical process to improve the dissolution rate of Eflucimibe |
미소장 |
| 25 | Thermal stability of solid dispersions of naphthalene derivatives with β-cyclodextrin and β-cyclodextrin polymers |
미소장 |
| 26 | G Khang, JH Lee, JW Lee, et al. , Preparation and characterization of PLGA microspheres for the sustained release of AZT, Korea Polymer J, 8, 80 (2000). | 미소장 |
| 27 | T Mizoe, T ozeki, H Okada, Preparation of drug nanoparticle containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms, J Control Release, 122, 10 (2007). | 미소장 |
| 28 | SJ Whang, MS Kim, SB Lee et al., Cilostazol composite composition having increasing solubility and process for preparing the same, Korea Patent, 10-2005-0038684 (20005). | 미소장 |
| 29 | S Seo, HS Choi, DH Lee, et al., Characteristic of nifedipine loaded PLGA wafer, Polymer(Korea), 25, 884 (2001). | 미소장 |
| 30 | Sibutramine Release Behavior from Microspheres Prepared by Spray-Dry Method | 소장 |
| 31 | JS Park, K Jeong, JH Lee, et al., Characterization and controlled release of solid dispersed sibutramine, J Kor Pharm Sci, 38, 119 (2008). | 미소장 |
| 32 | JH Park, S Kim, SI Ahn, et al., Characterization and improved dissolution rate of raloxifene HCl solid dispersion, Tissue Eng Regen Med, 6, 77 (2009). | 미소장 |
| 33 | JH Lee, JC Yang, YH Lee, et al., Effect of molecular weight of PVP on the release behavior of sibutramine solid dispersion, Tissue Eng Regen Med, 6, 148 (2009). | 미소장 |
| 34 | JH Park, J Ku, SI Ahn, et al., Characterization and release behavior of sibutramine HCl tablet with the additives, Tissue Eng Regen Med, 5, 729 (2008). | 미소장 |
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