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Bone is one of the most favored sites of tumor metastasis. However, the existent animal models developed

to understand mechanism of occurrence and progress of metastatic bone tumor generally showed difficulties of

reproducibility and performance of longitudinal study, and inaccuracy of validation. The aim of this study was,

therefore, to newly develop and accurately validate an animal model for study of metastatic bone tumor with overcome

of the limitations shown in the existent animal models. Eighteen female Sprague-Dawley rats (12 weeks old,

250+7 g) were randomly allocated in Sham and Tumor groups. W256 breast cancer cell was inoculated in the right

femur of the rat for Tumor group, while 0.9% NaCl was injected for Sham group. Urine was collected by metabolic

cages for DPD (deoxypyridinoline) test in order to evaluate bone resorption at 0, 4, 8, 12 weeks after surgery. At the

same time, the right hind limbs of all rats were scanned by in-vivo micro-computered tomography (CT) to identify

tumor-mediated bone destruction driven from metastatic bone tumor. Finally, positron emission tomography was

examined to directly identify existence of tumor cells inoculated in the bone. DPD test showed that bone resorption

markedly increased in the bone of Tumor group compared to that of Sham group (p<0.05). In-vivo micro-computed

tomography showed that there were significant bone losses and X-ray attenuation values in the bone of Tumor group

compared to that of Sham group after surgery. In addition, tumor cells were directly identified in the bone of Tumor

group by positron emission tomography, not in the bone of Sham group. The results indicated that the developed

animal model might be confidential and reasonable to performances of studies related to metastatic bone tumor, with

easy reproducibility, accuracy of validation, and suitability to performance of longitudinal study. To our knowledge,

this study may prove valuable as the first development of the animal model overcoming the limitations shown in the

existent animal models. The animal model developed in the present study may be useful for further metastatic bone

tumor studies as mentioned.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
A Novel Model of Osteonecrosis in the Knee Joint 홍승환, 김석중, 박현신, 장정호, 최선신, 우상훈, 주인탁, 이새봄, 박주희, 김장훈, 김선애 pp.37-41

Initial Osteoblast-like Cell Response to Titanium Coated with Recombinant Human Bone Morphogenic Protein-2(rhBMP-2) 이수영, 김성균, 심인경, 곽재영, 허성주, 이승진 pp.64-68

배아줄기세포에 의한 영양세포의 지방 분화 이순례, 박현숙 pp.82-86

자가골이식재로서 RGD펩타이드가 고정된 탈회상아질 전소영, Bodhraj Acharya, 신홍인, 박의균 pp.69-75

전이성골암 연구를 위한 동물모델 개발 및 검증 박선욱, 전옥희, 김지현, 김한성, 임도형, 전경진 pp.16-23

세포 배양 계대수가 마우스배아줄기세포의 특성에 미치는 영향 김해미, 이수만, 박경순, 김환희, 서원희 pp.76-81

Prevention of Postsurgical Tissue Adhesion by a Bi-layer Membrane Consisting of Adhesion and Lubrication Layers 조완진, 오세행, 김인걸, 이충식, 이진호 pp.49-56

Stem Cell-Based Hepatic Differentiation for Cell Therapy of Liver Diseases 안수연, 김종훈, 한지유 pp.1-8

Isolation Yield and Osteogenic Potential of Human Bone Marrow Stromal Cells Obtained from Different Sites 유정준, 전흥재, 김희중, 최원철 pp.101-107

지방유래 줄기세포가 이식된 Vicryl Mesh의 섬유화와 육아조직 형성에 미치는 영향 허찬영, 하현정, 김지회, 정의철, 은석찬, 김석화, 민경원, 백롱민 pp.32-36

랫드에서 PMMA와 Cross-Linked Dextran 혼합물의 생체 안전성 및 부피 효과에 대한 연구 장민우, 진부갑, 박성원, 김형석, 서국현, 한호재, 윤승필, 이상훈, 박재홍, 류정민, 문창종 pp.57-63

형상이 제어된 골 조직 재생용 3차원 지지체를 적용한 새로운 형태의 Perfusion Culture 이시우, 허수진, 장지연, 정재영, 김수향, 박수아, 전은수, 신정욱 pp.9-15

Preconditioning of Rabbit Mesenchymal Stem Cells in Polyglycolic Acid(PGA) Scaffold using Low-Intensity Ultrasound Improved Regeneration of Cartilage in Rabbit Articular Cartilage Defect Model Ji Hao Cui, 박소라, 최병현, 민병현 pp.24-31

The Chondrogenic Stimulating Effect of Fibroblast Growth Factor-2 on Adipose-Derived Stem Cells 유근수, 이은경, 이은아, 손영숙, 장정호 pp.93-100

Identification and Characterization of Phenotypic Markers of Human Mesenchymal Stem Cell-Derived Corneal Limbal Epithelial Cells 오주연, 김미금, 신경선, 위원량, 이진학 pp.87-92

혈관재생을 위한 혈관내피 전구세포(EPCs) 유래의 3차원 Scaffold-Free Spheroid의 개발 권상모, 김재원, 이정익 pp.42-48

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Mechanical properties, density and quantitative CT scan data of trabecular bone with and without metastases. 네이버 미소장
2 Density predicts the activity-dependent failure load of proximal femora with defects. 네이버 미소장
3 Mechanisms of bone metastasis. 네이버 미소장
4 Micro-CT combined with bioluminescence imaging: a dynamic approach to detect early tumor-bone interaction in a tumor osteolysis murine model. 네이버 미소장
5 J Pinski, T Dorff, Prostate cancer metastases to bone: Pathophysiology, pain management, and the promise of targeted therapy, European journal of cancer, 41, 932 (2005). 미소장
6 Mechanisms of bone metastasis. 네이버 미소장
7 So A, Hurtado-Col A, Nelson C, Mechanisms of the development of androgen independence in prostate cancer, World Journal of Urology, 23, 1 (2005). 미소장
8 Animal models of bone metastasis 네이버 미소장
9 S. Blouin, Rat models of bone metastasis, Clinical & Expeimental Metastasis, 22, 605 (2005). 미소장
10 The evaluation of a rat model for the analysis of densitometric and biomechanical properties of tumor-induced osteolysis. 네이버 미소장
11 P Honore, N Luger, M Sabino, et al., Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and painrelated neurochemical reorganization of the spinal cord, Nature Medicine, 6, 521 (2000). 미소장
12 K Mann, J Lee, S Arrington, et al., Predicting distal femur bone strength in a murine model of tumor osteolysis, Clinical orthopaedics and related research, 466, 1271 (2008). 미소장
13 Biochemical Markers of Bone Metabolism in Animals: Uses and Limitations 네이버 미소장
14 Pyridinoline cross-links as markers for primary and secondary bone tumors. 네이버 미소장
15 A Kurth, SZ Kim, M Shea, et al., Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis, Journal of Bone and Mineral Metabolism, 25, 86 (2007). 미소장
16 The evaluation of a rat model for the analysis of densitometric and biomechanical properties of tumor-induced osteolysis. 네이버 미소장
17 D Heymann, Bone Cancer, Nantes; Academic Press (2009). 미소장
18 Bone imaging in metastatic breast cancer. 네이버 미소장
19 Matrix proteins of the skeleton 네이버 미소장
20 Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. 네이버 미소장
21 Factors affecting the assay of urinary 3-hydroxy pyridinium crosslinks of collagen as markers of bone resorption. 네이버 미소장
22 PB S.L. Weitz, S.S. Leung, Total deoxypyridinoline in serum and urine as measured by a novel adaptation of pyrilinks-D enzyme ummunoassay, the 21th annual meeting of the American Society for Bone and Mineral Research, 3510 (1999). 미소장
23 The use of standardized uptake values for assessing FDG uptake with PET in oncology: a clinical perspective. 네이버 미소장
24 R Boellaard, N Krak, O Hoekstra, et al., Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values: A simulation study, The Journal of Nuclear Medicine, 45, 1519 (2004). 미소장
25 Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging. 네이버 미소장

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