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Background/Aims: The most appropriate treatment for acute gastric variceal bleeding (GVB) is currently endoscopic gastric variceal obturation (GVO) using Histoacrylⓡ. However, the secondary prophylactic efficacy of beta-blocker (BB) after GVO for the first acute episode of GVB has not yet been established. The secondary prophylactic efficacy of BB after GVO for the first acute episode of GVB was evaluated in this study. Methods: Ninety-three patients at Soonchunhyang University Hospital with acute GVB who received GVO using Histoacrylⓡ were enrolled between June 2001 and March 2010. Among these, 42 patients underwent GVO alone (GVO group) and 51 patients underwent GVO with adjuvant BB therapy (GVO+BB group). This study was intended for patients in whom a desired heart rate was reached. The rates of rebleeding-free survival and overall survival were calculated for the two study groups using Kaplan-Meyer analysis and Cox’s proportional-hazards model. Results: The follow-up period after the initial eradication of gastric varices was 18.14±25.22 months (mean±SD). During the follow-up period, rebleeding occurred in 10 (23.8%) and 21 (41.2%) GVO and GVO+BB patients, respectively, and 39 patients died [23 (54.8%) in the GVO group and 16 (31.4%) in the GVO+BB group]. The mean rebleeding-free survival time did not differ significantly between the GVO and GVO+BB groups (65.40 and 37.40 months, respectively; P=0.774), whereas the mean overall survival time did differ (52.54 and 72.65 months, respectively; P=0.036). Conclusions: Adjuvant BB therapy after GVO using Histoacrylⓡ for the first acute episode of GVB could decrease the mortality rate relative to GVO alone. However, adjuvant BB therapy afforded no benefit for the secondary prevention of rebleeding in GV. (Clin Mol Hepatol 2013;19:280-287)

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
The secondary prophylactic efficacy of beta-blocker after endoscopic gastric variceal obturation for first acute episode of gastric variceal bleeding 최문한, 김영석, 김상균, 이윤나, 서유리, 김민진, 이세환, 정승원, 장재영, 김홍수, 김부성 pp.280-287

Regional prevalence of non-alcoholic fatty liver disease in Seoul and Gyeonggi-do, Korea 정은행, 전대원, 조용균, 최영길, 류승호, 이승민, 장은철 pp.266-272

Elevated red cell distribution width is associated with advanced fibrosis in NAFLD 김화목, 김병익, 조용균, 손정일, 전우규, 김홍주, 박동일, 박정호, 주관중, 김창준, 김범수, 김용성, 허원재, 최원석 pp.258-265

Genotype-4 hepatitis E in a human after ingesting roe deer meat in South Korea 최자윤, 이정미, 조윤원, 민현주, 김현진, 정원태, 이옥재, 윤해선, 윤영실 pp.309-314

Lamivudine plus adefovir combination therapy for lamivudine resistance in hepatitis-B-related hepatocellular carcinoma patients 고순영, 김정한, 최원혁, 권소영, 이창훈 pp.273-279

Co-development of autoimmune hepatitis and Sjögren's syndrome triggered by the administration of herbal medicines 오효정, 목영미, 백문성, 이지경, 김태현, 최금하, 황인겸, 라지은, 오용렬, 김용성, 조은영, 김학철, 손영우 pp.305-308

Efficacy and safety of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma as firstline therapy 오명진, 이헌주, 이시형 pp.288-299

Durability after discontinuation of nucleos(t)ide therapy in chronic HBeAg negative hepatitis patients 김영집, 김기찬, 황선혁, 김순선, 이다미, 정재연, 조성원 pp.300-304

참고문헌 (32건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Gastric varices: profile, classification, and management. 네이버 미소장
2 Management of gastric variceal haemorrhage. 네이버 미소장
3 Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. 네이버 미소장
4 Classification of gastric lesions associated with portal-hypertension 네이버 미소장
5 Direction of splenic venous flow assessed by pulsed Doppler flowmetry in patients with a large splenorenal shunt 네이버 미소장
6 Endoscopic injection sclerosis in bleeding gastric varices 네이버 미소장
7 Portal hemodynamics in patients with gastric varices 네이버 미소장
8 Endoscopic Diagnosis of Gastric Varices 네이버 미소장
9 Pathomorphology of esophageal and gastric varices. 네이버 미소장
10 A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices 네이버 미소장
11 The treatment of portal hypertension: A meta-analytic review 네이버 미소장
12 Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension 네이버 미소장
13 Endoscopic obliteration of large esophagogastric varices with bucrylate. 네이버 미소장
14 Endoscopic sclerotherapy in the treatment of gastric varices. 네이버 미소장
15 Gastric variceal ligation: a new technique 네이버 미소장
16 Rossle M, Richter G, Noldge G, Haag K, Wenz W, Gerck W, et al. Performance of an intrahepatic portacaval shunt (PCS) using a catheter technique: a case report. [Abstract]. Hepatology 1988;8:1348. 미소장
17 Treatment of gastric fundal varices by balloon‐occluded retrograde transvenous obliteration 네이버 미소장
18 Endoscopic treatment of bleeding gastric varices by N-butyl-2-cyanoacrylate (Histoacryl) injection: long-term efficacy and safety 네이버 미소장
19 Long-term results of endoscopic Histoacryl injection sclerotherapy for gastric variceal bleeding: A 10-year experience 네이버 미소장
20 Long-term Results of Endoscopic Histoacryl? (N-butyl-2-cyanoacrylate) Injection for Treatment of Gastric Varices -A 10-year Experience- 소장
21 Meta-analysis: Combination Endoscopic and Drug Therapy to Prevent Variceal Rebleeding in Cirrhosis 네이버 미소장
22 Transection of the oesophagus for bleeding oesophageal varices. 네이버 미소장
23 A model to predict survival in patients with end‐stage liver disease 네이버 미소장
24 N-Butyl-2-Cyanoacrylate Pulmonary Embolism After Endoscopic Injection Sclerotherapy for Gastric Variceal Bleeding 네이버 미소장
25 Multiple systemic embolisms with septicemia after gastric variceal obliteration with cyanoacrylate 네이버 미소장
26 Randomized, prospective study of cyanoacrylate injection, sclerotherapy, or rubber band ligation for endoscopic hemostasis of bleeding canine gastric varices 네이버 미소장
27 A randomized controlled trial of cyanoacrylate versus alcohol injection in patients with isolated fundic varices 네이버 미소장
28 A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices 네이버 미소장
29 Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data. 소장
30 Cost-effectiveness of N-butyl-2-cyanoacrylate (histoacryl) glue injections versus transjugular intrahepatic portosystemic shunt in the management of acute gastric variceal bleeding 네이버 미소장
31 Endoscopic cyanoacrylate injection versus beta-blocker for secondary prophylaxis of gastric variceal bleed: a randomised controlled trial. 네이버 미소장
32 Effect of Endoscopic Sclerotherapy Using N-butyl-2-cyanoacrylate in Patients with Gastric Variceal Bleeding 네이버 미소장