대표어
한국학술지인용색인(NRF)
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Objectives : Mori Folium was popularly used as one of the traditional medicinal herbs. Although M. Folium has been cultivated for rearing silkworm historically, it's use has been expanded as natural therapeutic agent for the treatment of filariasis, diabetes and dropsy in East Asia. However, little has been known about the effect of M. Folium on liver fibrosis. Therefore, we would like to explore an anti-fibrogenic potential of M. Folium extract (MFE) using immortalized human hepatic stellate cell line, LX-2 cells.
Methods : We examined the effects of MFE on the transforming growth factor β1 (TGFβ1)-induced liver fibrosis in LX-2 cells. Cell viability, Smad binding element-driven luciferase activity, phosphorylations level of Smad 2/3, and expression level of TGFβ1-dependent target genes were monitored in the MFE-treated LX-2 cells.
Results : Up to 30 μg/ml MFE treatment did not show any possible toxic effect in LX-2 cells. MFE inhibited TGFβ1-inducible Smad binding element-driven luciferase activity and decreased the TGFβ1-inducible phosphorylations of Smad 2 and Smad 3 in hepatic stellate cell in a dose dependent manner. Furthermore, increases of plasminogen activator inhibitor type 1, TGFβ1 and matrix metalloproteinases 2 genes by TGFβ1 were also attenuated by MFE treatment.
Conclusions : These findings suggested that MFE would be used as a potential therapeutic agent for the treatment liver fibrosis, which might be mediated by the inhibition of TGFβ1-inducible Smad 2/3 transactivation and target genes expression.권호기사
참고문헌 (26건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Bataller B, Brenner DA. Hepatic Fibrosis. In : Arias IM, Alter HJ, Boyer JL, Cohen DE, Fausto N, Shafritz DA, Wolkoff AW, eds. The liver biology and pathobiology. 5th ed. Oxford : Wiley-Blackwell. 2009 : 433-52. | 미소장 |
| 2 | [The role of activated hepatic stellate cells in liver fibrosis, portal hypertension and cancer angiogenesis].  |
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| 3 | Hepatic Expression of Mature Transforming Growth Factor β1 in Transgenic Mice Results in Multiple Tissue Lesions |
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| 4 | Smads 2 and 3 Are Differentially Activated by Transforming Growth Factor-β (TGF-β) in Quiescent and Activated Hepatic Stellate Cells |
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| 5 | Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts. |
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| 6 | Direct binding of Smad3 and Smad4 to critical TGF�-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene |
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| 7 | Cho IJ, Kim SH, Kim SG. Inhibition of TGFβ 1-mediated PAI-1 induction by oltipraz through selective interruption of Smad 3 activation. Cytokines. 2006 ; 35 : 284-94. | 미소장 |
| 8 | E‐cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA–dependent Smad3 phosphorylation |
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| 9 | The Korean Medical Dictionary Compliation Committee. The Korean Medical Dictionary. Seoul : Jungdam. 1998 : 727. | 미소장 |
| 10 | Inhibitory effect of Mori Folium ethanol extract on pro-inflammatory mediator in lipopolysaccharide-activated RAW 264.7 cells | 소장 |
| 11 | Administration of Folium mori extract decreases nitric oxide synthase expression in the hypothalamus of streptozotocin-induced diabetic rats. |
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| 12 | Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice |
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| 13 | Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice |
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| 14 | Biphasic effects of Morus alba leaves green tea extract on mice in chronic forced swimming model |
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| 15 | Transforming growth factor b signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts |
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| 16 | Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. |
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| 17 | Controlling TGF-beta signaling. |
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| 18 | Smad3 Specific Inhibitor, Naringenin, Decreases the Expression of Extracellular Matrix Induced by TGF-β1 in Cultured Rat Hepatic Stellate Cells |
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| 19 | Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation. |
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| 20 | Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats |
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| 21 | Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells |
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| 22 | Studies on the constituents of the leaves of Morus alba L. |
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| 23 | Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance. |
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| 24 | Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. |
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| 25 | Protective effect of quercetin on liver damage induced by biliary obstruction in rats |
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| 26 | Protective Effect of Morin on Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats |
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