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Purpose: The serum level of carcinoembryonic antigen (CEA) is a clinical prognostic factor in the follow-up evaluation of patients with colon cancer. We aimed to evaluate the prognostic significance of the rate of decrease of the perioperative serum CEA level in patients with colon cancer after a curative resection.

Methods: A total of 605 patients who underwent a curative resection for colon cancer between January 2000 and December 2007 were enrolled retrospectively. The rate of decrease was calculated using the following equation: ([preoperative CEA - postoperative CEA]/[preoperative CEA] ×100).

Results: In the group with a preoperative serum CEA level of >5 ng/mL, the normalized group with a postoperative serum CEA level of ≤5 ng/mL showed a better overall survival (OS) rate and disease-free survival (DFS) rate than those of the nonnormalized group (P ≤ 0.0001). The “cutoff values” of the rate of decrease in the perioperative serum CEA that determined the OS and the DFS were 48.9% and 50.8%, respectively. In the multivariate analysis of preoperative serum CEA levels >5ng/mL, the prognostic factors for the OS and the DFS were the cutoff value (P < 0.0001) and the pN stage (P < 0.0001).

Conclusion: A rate of decrease of more than 50% in the perioperative serum CEA level, as well as the normalization of the postoperative serum CEA level, may be useful factors for determining a prognosis for colon cancer patients with high preoperative CEA levels.

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기사명 저자명 페이지 원문 목차
Prognostic Significance of the Decreased Rate of Perioperative Serum Carcinoembryonic Antigen Level in the Patients With Colon Cancer After a Curative Resection 정태두, 유종한, 이민재, 박하경, 신재호, 안민성, 하태권, 김광희, 배기범, 김태현, 최창수, 오민경, 홍관희 pp.115-122

Prognostic Impact of the Metastatic Lymph Node Ratio on Survival in Rectal Cancer Wafi Attaallah, Omer Gunal, Manuk Manukyan, Gulden Ozden, Cumhur Yegen pp.100-105

Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis 김정연, 정동준, 안태성, 김형주, 박두산, 박소영, 배상병, 이수경, 이성수, 이문수, 조현득, 백무준 pp.93-99

Primary Multiple Mesenteric Liposarcoma of the Transverse Mesocolon Sandeep Sachidananda, Arunkumar Krishnan, Raja Ramesh, Sivaprakasam Kuppurao pp.123-125

Individualized Cutoff Value of the Preoperative Carcinoembryonic Antigen Level is Necessary for Optimal Use as a Prognostic Marker 전병건, 정중기, 정인목, 허승철, 신루미 pp.106-114

Mucosal Schwann-Cell Hamartoma Diagnosed by Using an Endoscopic Snare Polypectomy 배명남, 이정은, 배상묵, 김은영, 김은옥, 정성훈, 오정환, 민기옥 pp.130-134

Intramural Recurrence Without Mucosal Lesions After an Endoscopic Mucosal Resection for Early Colorectal Cancer 김민성, 김남규, 박지혜 pp.126-129

참고문헌 (22건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Adjuvant therapy of colon cancer 네이버 미소장
2 Greene FL, Balch CM, Fleming ID, editors. AJCC cancer staging handbook: TNM classification of malignant tumors. 6th ed. New York: Springer; 2002. 미소장
3 Prognostic significance of pre- and postoperative serum carcinoembryonic antigen levels in patients with colorectal cancer. 네이버 미소장
4 Klee GG, Go VJW. Carcinoembryonic antigen and its role in clinical practice. In: Ghosh BC, Ghosh L, editors. Tumor markers and tumor-associated antigens. New York: Mc-Graw-Hill; 1990. p. 22-43. 미소장
5 Arfa N, Hamdani I, Gharbi L, Ben Abid S, Ghariani B, Mannai S, et al. Survival and prognostic factors of colorectal adenocarcinoma: analytic multifactor review of 150 cases. Ann Chir 2006;131: 104-11. 미소장
6 Preoperative Carcinoembryonic Antigen Level as an Independent Prognostic Factor in Colorectal Cancer: Taiwan Experience 네이버 미소장
7 Specific carcinoembryonic antigens of the human digestive system. 네이버 미소장
8 Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. 네이버 미소장
9 Chen CC, Yang SH, Lin JK, Lin TC, Chen WS, Jiang JK, et al. Is it reasonable to add preoperative serum level of CEA and CA19-9 to staging for colorectal cancer? J Surg Res 2005;124:169-74. 미소장
10 The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer. 네이버 미소장
11 Patterns of failure after surgical cure of large liver tumors: A change in the proximate cause of death and a need for effective systemic adjuvant therapy 네이버 미소장
12 Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, editors. AJCC cancer staging manual. 7th ed. New York: Springer; 2010. 미소장
13 Compton CC, Fielding LP, Burgart LJ, Conley B, Cooper HS, Hamilton SR, et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 2000;124:979-94. 미소장
14 Assessment of serial carcinoembryonic antigen: determinations to monitor the therapeutic progress and prognosis of metastatic liver disease treated by regional chemotherapy. 네이버 미소장
15 Bruinvels DJ, Stiggelbout AM, Kievit J, van Houwelingen HC, Habbema JD, van de Velde CJ. Follow-up of patients with colorectal cancer. A meta-analysis. Ann Surg 1994;219:174-82. 미소장
16 A simplified plan for follow-up of patients with colon and rectal cancer supported by prospective studies of laboratory and radiologic test results. 네이버 미소장
17 Tate H. Plasma CEA in the post-surgical monitoring of colorectal carcinoma. Br J Cancer 1982;46:323-30. 미소장
18 Slentz K, Senagore A, Hibbert J, Mazier WP, Talbott TM. Can preoperative and postoperative CEA predict survival after colon cancer resection? Am Surg 1994;60:528-31. 미소장
19 Prognostic use of preoperative and immediate postoperative carcinoembryonic antigen determinations in colonic cancer. 네이버 미소장
20 Factors influencing the pharmacokinetics, dosimetry, and diagnostic accuracy of radioimmunodetection and radioimmunotherapy of carcinoembryonic antigen-expressing tumors. 네이버 미소장
21 Park YA, Lee KY, Kim NK, Baik SH, Sohn SK, Cho CW. Prognostic effect of perioperative change of serum carcinoembryonic antigen level: a useful tool for detection of systemic recurrence in rectal cancer. Ann Surg Oncol 2006;13:645-50. 미소장
22 The prognostic significant of percentage drop in serum CEA post curative resection for colon cancer 네이버 미소장

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