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Mollugin is the active compound of Rubia cordifolia, a well known herb widely used in alternative medicines for the treatment of various inflammatory diseases including arthritis and uteritis. In the present study, we investigated the anti-inflammatory effects of mollugin in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophage cells.

Treatment with mollugin significantly inhibited LPS-induced release of nitric oxide, prostaglandin E2, and inflammatory cytokines, such as tumor necrosis factor-α and interleukin-6. In addition, mollugin suppressed LPS-induced nuclear factor-kappa B (NF-κB) transcriptional activity. These results suggest that mollugin inhibits LPS-induced expression of inflammatory molecules via NF-κB, at least in part, and indicate the potential value of mollugin as a valuable new drug candidate for the treatment of various inflammatory diseases.

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기사명 저자명 페이지 원문 목차
Fenofibrate Inhibits Visceral Adiposity by Inhibiting UCPs in C57BL/6J Mice Fed on a High Fat Diet 오재호, 윤미정 pp.355-361

Total Cholesterol and Alkaline Phosphatase are Increased in D/D Type of Angiotensin Converting Enzyme 김성수 pp.406-412

The House Dust Mite Allergen, Dermatophagoides pteronyssinus Suppresses the Chemotactic Activity of Human Monocytes 이지숙, 김인식, 양은주 pp.435-437

Evaluation of Enterotoxigenic Bacteroides fragilis from Colonic Washings from Patients Undergoing Colonoscopy Ni Van, Ned Ahlberg, 김윤석, 이기종, 정병철, 이민호, 안승주, 이인수 pp.362-368

Mollugin-mediated Inhibition of Proinflammatory Biomarkers in Lipopolysaccharide-stimulated RAW264.7 Cells 김진경, 박근묵, 전종갑 pp.338-344

Effects of the Photic Stimulation on Electroencephalogram in Pediatric Epilepsy Patients 윤중수, 최현주 pp.428-434

Utilization of Averaging Process of Blink Reflex to Improve Diagnosis of Facial Nerve Palsy 유종균, 김대식, 조정희 pp.391-398

Assay System for N-acylethanolamines Degradation Enzyme, N-acylethanolamine-hydrolyzing Acid Amidase 김대웅, 길성호, 김건중 pp.438-444

Immunohistochemical Changes of Apoptotic Control Genes by Chronic Inhibition of Nitric Oxide in Rats 배형준 pp.420-427

The Relationship between the Expression of Melanoma Differentiation-Associated Gene-7/Interleukin-24 (MDA-7/IL-24) and Clinicopathological Features in Colorectal Adenocarcinomas 서보람, 노미숙, 홍영섭, 영민 pp.413-419

Comparison of Stress and Physiological Variables between Diabetic and Nondiabetic Adults 한병조, 현경예, 최석철, 문성민, 김대식 pp.384-390

The Anti-inflammatory Mechanism of Xanthoangelol E is Through the Suppression of NF-κB/Caspase-1 Activation in LPS-stimulated Mouse Peritoneal Macrophage 서정호, 김수진 pp.345-354

Macromolecular Crowding Enhances Interaction of α-synuclein with Vesicles 김윤석, 김정한, 이지아, 고제상, 박용석, 이승재 pp.329-337

Statistical Techniques based Computer-aided Diagnosis (CAD) using Texture Feature Analysis : Applied of Cerebral Infarction in Computed Tomography (CT) Images 이재승, 임인철, 유윤식, Hyong-Hu Park, 곽병준 pp.399-405

Replicated Association between SLC4A4 Gene and Blood Pressure Traits in the Korean Population 진현석, 엄용빈 pp.377-383

Platycodon grandiflorum Extracts Exhibits Anti-inflammatory Properties by Down-regulating MAPK Signaling Pathways Lipopolysaccharide-treated RAW264.7 Cells 김현진, 김진경, 정성윤 pp.369-376

참고문헌 (31건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Suppression of the Nuclear Factor‐κB Activation Pathway by Spice‐Derived Phytochemicals: Reasoning for Seasoning 네이버 미소장
2 Checker R, Sandur SK, Sharma D, Patwardhan RS, Jayakumar S, Kohli V, Sethi G, Aggarwal BB, Sainis KB. Potent antiinflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT. PLoS One. 2012. 7: e31318. 미소장
3 Signal transduction pathways of inflammatory gene expressions and therapeutic implications. 네이버 미소장
4 Antiplatelet constituents of formosan Rubia akane. 네이버 미소장
5 Transcriptional control of the TNF gene. 네이버 미소장
6 Nitric oxide synthases: regulation and function. 네이버 미소장
7 Should More Patients Continue Aspirin Therapy Perioperatively?: Clinical Impact of Aspirin Withdrawal Syndrome 네이버 미소장
8 Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia. 네이버 미소장
9 Effect of mollugin on apoptosis and adipogenesis of 3T3-L1 preadipocytes. 네이버 미소장
10 A facile synthesis of mollugin 소장
11 The mutagenic constituents of Rubia tinctorum. 네이버 미소장
12 Anti-inflammatory plant flavonoids and cellular action mechanisms. 네이버 미소장
13 Regulation of the expression of inducible nitric oxide synthase. 네이버 미소장
14 Potential of Cameroonian plants and derived products against microbial infections: a review. 네이버 미소장
15 Inflammation Markers in Individuals with History of Mental Health Crisis 네이버 미소장
16 Drug Discovery and Natural Products: End of an Era or an Endless Frontier? 네이버 미소장
17 NFkappaB-dependent signaling pathways. 네이버 미소장
18 NFκB: a promising target for natural products in cancer chemoprevention 네이버 미소장
19 Mutagenicity of natural anthraquinones from Rubia tinctorum in the Drosophila wing spot test. 네이버 미소장
20 Saponins in yerba mate tea ( Ilex paraguariensis A. St.-Hil) and quercetin synergistically inhibit iNOS and COX-2 in lipopolysaccharide-induced macrophages through NFkappaB pathways. 네이버 미소장
21 Qi LW, Liu EH, Chu C, Peng YB, Cai HX, Li P. Anti-diabetic agents from natural products--an update from 2004 to 2009. Curr Top Med Chem. 2010. 10: 434-457. 미소장
22 LPS-induced cytokine production in human monocytes and macrophages. 네이버 미소장
23 Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process. 네이버 미소장
24 Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis. 네이버 미소장
25 Stoffel A. The NF-kappaB signalling pathway: a therapeutic target in lymphoid malignancies? Expert Opin Ther Targets. 2005. 9: 1045-1061. 미소장
26 NF-κB as a potential therapeutic target in microbial diseases. 네이버 미소장
27 Effect of NF-κB signaling on apoptosis in chronic inflammation-associated carcinogenesis. 네이버 미소장
28 Anti-inflammatory glucocorticoid drugs: reflections after 60 years 네이버 미소장
29 Control of COX-2 and iNOS gene expressions by aspirin and salicylate 네이버 미소장
30 Tea and cancer prevention: Epidemiological studies 네이버 미소장
31 Novel therapies in phase II and III trials for malignant pleural mesothelioma. 네이버 미소장

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