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초록보기

Silk fibroin (SF) peptide has been traditionally used as a

treatment for flatulence, spasms, and phlegm. In this study,

we examined whether SF peptide enhanced the antiinflammatory

effect of PEP-1-FK506 binding protein

(PEP-1-FK506BP) through comparing the anti-inflammatory

activities of SF peptide and/or PEP-1-FK506BP. In the

presence or absence of SF peptide, transduction levels of

PEP-1-FK506BP into HaCaT cells and mice skin and

anti-inflammatory activities of PEP-1-FK506BP were

identified by Western blot and histological analyses. SF

peptide alone effectively reduced both mice ear edema

and the elevated levels of cyclooxygenase-2, interleukin-6

and -1β, and tumor necrosis factor-α, showing similar

anti-inflammatory effect to that of PEP-1-FK506BP.

Furthermore, co-treatment with SF peptide and PEP-1-

FK506BP exhibited more enhanced anti-inflammatory

effects than the samples treated with SF peptides or PEP-

1-FK506BP alone, suggesting the possibility that SF

peptide and PEP-1-FK506BP might interact with each

other. Moreover, the transduction data demonstrated that

SF peptide did not affect the transduction of PEP-1-

FK506BP into HaCaT cells and mice skin, indicating that

the improvement of anti-inflammatory effect of PEP-1-

FK506BP was not caused by enhanced transduction of

PEP-1-FK506BP. Thus, these results suggest the possibility

that co-treatment with SF peptide and PEP-1-FK506BP may

be exploited as a useful therapy for various inflammationrelated

diseases.

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기사명 저자명 페이지 원문 목차
Characterization of a New β-Lactamase Gene from Isolates of Vibrio spp. in Korea Jun, Lyu Jin, Jae Hoon Kim, 진지웅, Hyun Do Jeong pp.555-562

Comparison of Alpha-Factor Preprosequence and a Classical Mammalian Signal Peptide for Secretion of Recombinant Xylanase xynB from Yeast Pichia pastoris He, Zuyong, Yuankai Huang, Yufeng Qin, Zhiguo Liu, Delin Mo, Peiqing Cong, Yaosheng Chen pp.479-483

Biochemical and Molecular Characterization of High Population Density Bacteria Isolated from Sunflower Goes, Kelly Campos Guerra Pinheiro de, Maria Luisa de Castro Fisher, Alexandre José Cattelan, Marco Antonio Nogueira, Claudio Guilherme Portela de Carvalho, André Luiz Martinez de Oliveira pp.437-447

Characterization of the BolA Homolog IbaG : A New Gene Involved in Acid Resistance Guinote, Inês Batista, Ricardo Neves Moreira, Patrick Freire, Cecília Maria Arraiano pp.484-493

In Vitro Activities of Antimicrobials Against Brucella abortus Isolates from Cattle in Korea During, 1998-2006 Heo, Eun-Jeong, Sung-Il Kang, Jong-Wan Kim, Moon Her, In-Yeong Hwang, Jin-San Moon, Sung-Hwan Wee, Donghee Cho, Yun-Sang Cho, Suk-Chan Jung, Hyang-Mi Nam pp.567-570

Comparative Analysis of Envelope Proteomes in Escherichia coli B and K-12 Strains Han, Mee-Jung, Sang Yup Lee, Soon Ho Hong pp.470-478

Growth Response of Avena sativa in Amino-Acids-Rich Soils Converted from Phenol-Contaminated Soils by Corynebacterium glutamicum Lee, Soo Youn, Bit-Na Kim, Yong Woo Choi, 유계상, Yang-Hoon Kim, 민지호 pp.541-546

Cloning and Characterization of Ginsenoside Ra1-Hydrolyzing β-D-Xylosidase from Bifidobacterium breve K-110 현양진, Bomi Kim, 김동현 pp.535-540

Monitoring of Horizontal Gene Transfer from Agricultural Microorganisms to Soil Bacteria and Analysis of Microbial Community in Soils Kim, Sung Eun, 문제선, Won Sik Choi, Sang Han Lee, Sung Uk Kim pp.563-566

Metagenomic Analysis of Novel Lignocellulose-Degrading Enzymes from Higher Termite Guts Inhabiting Microbes Nimchua, Thidarat, Taksawan Thongaram, Tanaporn Uengwetwanit, Somchai Pongpattanakitshote, Lily Eurwilaichitr pp.462-469

Hexavalent Chromium Reduction by Bacteria from Tannery Effluent Batool, Rida, Kim Yrjälä, Shahida Hasnain pp.547-554

Genetic and Phenotypic Diversity of Carbofuran-Degrading Bacteria Isolated from Agricultural Soils Shin, Dong-Hyeon, Dong-Uk Kim, 성치남, Hong-Gyu Song, Jong-Ok Ka pp.448-456

Molecular and Biochemical Characterization of a Novel Intracellular Low-Temperature-Active Xylanase Zhou, Junpei, Xianghua Tang, Junjun Li, Bo Xu, Qian Wu, Yajie Gao, Lu Pan, Zunxi Huang, Yanyan Dong pp.501-509

Visualization of Candidate Division OP3 Cocci in Limonene-Degrading Methanogenic Cultures Rotaru, Amelia-Elena, Regina Schauer, Christina Probian, Marc Mussmann, Jens Harder pp.457-461

Effect of a Probiotic Strain, Enterococcus faecium, on the Immune Responses of Olive Flounder(Paralichthys olivaceus) Kim, Yu-Ri, Eun-Young Kim, Sun-young Choi, Muhammad Tofazzal Hossain, Ryunkyoung Oh, Won-Seok Heo, Jong Min Lee, Young Chai Cho, In-Soo Kong pp.526-529

Development of Real-Time PCR for the Detection of Clostridium perfringens in Meats and Vegetables Chon, Jung-Whan, Jong-Seok Park, Ji-Yeon Hyeon, 박찬규, Kwang-Young Song, Kwang-Won Hong, In-Gyun Hwang, Hyo-Sun Kwak, Kun-Ho Seo pp.530-534

Proteomic Analysis of Proteins Increased or Reduced by Ethanol of Lactobacillus plantarum ST4 Isolated from Makgeolli, Traditional Korean Rice Wine Lee, Seung Gyu, Kang Wook Lee, Tae Heung Park, Ji Yeong Park, Nam Soo Han, Jeong Hwan Kim pp.516-525

Glyceraldehyde-3-Phosphate, a Glycolytic Intermediate, Prevents Cells from Apoptosis by Lowering S-Nitrosylation of Glyceraldehyde-3-Phosphate Dehydrogenase Lee, Sun Young, Jeong Hoon Kim, Hyeyun Jung, Seung Wook Chi, Sang J. Chung, 이종길, 박병철, Kwang-Hee Bae, Sung Goo Park pp.571-573

Large Increase in Leuconostoc citreum KM20 Dextransucrase Activity Achieved by Changing the Strain/Inducer Combination in an E. coli Expression System Ko, Jin-A, Young-Min Kim, Hyung Jae Jeong, Young Bae Ryu, Su-Jin Park, 위영중, Doman Kim, Woo Song Lee pp.510-515

Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide Kim, Dae Won, Hyun Sook Hwang, Duk-Soo Kim, Seung Hoon Sheen, Dong Hwa Heo, Gyojun Hwang, Suk Hyung Kang, Hae Yong Kweon, You-Young Jo, Seok Woo Kang, Kwang-Gill Lee, Jinseu Park, Won Sik Eum, Yong-Jun Cho, Soo Young Choi pp.494-500

참고문헌 (30건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Bickers, D. R. and M. Athar. 2006. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 126: 2565-2575. 미소장
2 The Involvement of Mammalian and Plant FK506-Binding Proteins (FKBPs) in Development 네이버 미소장
3 Dietz, G. P. 2010. Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research. Curr. Pharm. Biotechol. 11: 167-174. 미소장
4 Dunlop, E. A. and A. R. Tee. 2009. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cell Signal. 21: 827-835. 미소장
5 Role of oxygen free radicals in carcinogenesis and brain ischemia. 네이버 미소장
6 Cancer‐specific survival outcomes among patients treated during the cytokine era of kidney cancer (1989‐2005) 네이버 미소장
7 Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. 네이버 미소장
8 Nuclear factor-kappaB/Rel proteins: a point of convergence of signalling pathways relevant in neuronal function and dysfunction. 네이버 미소장
9 Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes. 네이버 미소장
10 Biotechnology and bioeconomy in China. 네이버 미소장
11 FKBP Family Proteins: Immunophilins with Versatile Biological Functions 네이버 미소장
12 Low molecular weight silk fibroin increases alkaline phosphatase and type Ⅰ collagen expression in MG63 cells 네이버 미소장
13 Transduced PEP-1-FK506BP inhibits the inflammatory response in the Raw 264.7 cell and mouse models 네이버 미소장
14 Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice 네이버 미소장
15 Enhancement of HIV-1 tat fusion protein transduction efficiency by bog blueberry anthocyanins 소장
16 FK506 Binding Protein 12/12.6 Depletion Increases Endothelial Nitric Oxide Synthase Threonine 495 Phosphorylation and Blood Pressure 네이버 미소장
17 Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. 네이버 미소장
18 Stabilization of enzymes in silk films. 네이버 미소장
19 Mates, J. M. 2000. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 83: 83-104. 미소장
20 Points of control in inflammation. 네이버 미소장
21 Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/ trans isomerases 네이버 미소장
22 Protein Translocation: How Hsp70 Pulls It Off 네이버 미소장
23 Effects of pergolide mesylate on transduction efficiency of PEP-1-catalase protein 네이버 미소장
24 Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice 네이버 미소장
25 Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate. 네이버 미소장
26 Protein transduction technology 네이버 미소장
27 Wadia, J. S. and S. F. Dowdy. 2003. Modulation of cellular function by TAT mediated transduction of full length proteins. Curr. Protein Pept. Sci. 4: 97-104. 미소장
28 Specific Interaction of Type I Receptors of the TGF-β Family with the Immunophilin FKBP-12 네이버 미소장
29 Endocrine disruption for endocrinologists (and others). 네이버 미소장
30 Zhou, H., A. Lin, Z. Gu, S. Chen, N. H. Park, and R. Chiu.2000. 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalizedor transformed epithelial cells refractory to TPA-inducible JNKactivity. J. Biol. Chem. 275: 22868-22875. 미소장

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