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PurposeThis study was conducted to evaluate the efficacy and safety of azasetron comparedto ondansetron in the prevention of delayed chemotherapy-induced nausea andvomiting.

Materials and MethodsThis study was a multi-center, prospective, randomized, double-dummy, double-blindand parallel-group trial involving 12 institutions in Korea between May 2005 andDecember 2005. A total of 265 patients with moderately and highly emetogenicchemotherapy were included and randomly assigned to either the azasetron orondansetron group. All patients received azasetron (10 mg intravenously) anddexamethasone (20 mg intravenously) on day 1 and dexamethasone (4 mg orally every12 hours) on days 2-4. The azasetron group received azasetron (10 mg orally) withplacebo of ondansetron (orally every 12 hours), and the ondansetron group receivedondansetron (8 mg orally every 12 hours) with placebo of azasetron (orally) on days2-6.

ResultsOver days 2-6, the effective ratio of complete response in the azasetron andondansetron groups was 45% and 54.5%, respectively (95% confidence interval,?21.4 to 2.5%). Thus, the non-inferiority of azasetron compared with ondansetron indelayed chemotherapy-induced nausea and vomiting was not proven in the presentstudy. All treatments were well tolerated and no unexpected drug-related adverseevents were reported. The most common adverse events related to the treatmentwere constipation and hiccups, and there were no differences in the overall incidenceof adverse events.

ConclusionIn the present study, azasetron showed inferiority in the control of delayed chemotherapy-induced nausea and vomiting compared with ondansetron whereas safety profileswere similar between the two groups.

권호기사

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기사명 저자명 페이지 원문 목차
High-Dose-Rate Brachytherapy for the Treatment of Vaginal Intraepithelial Neoplasia 송진호, 이주환, 이종훈, 박종섭, 홍숙희, 장홍석, 김연실, 최병옥, 윤세철 pp.74-80

Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin : the Golden Pigment from Golden Spice Sahdeo Prasad, Amit K. Tyagi, Bharat B. Aggarwal pp.2-18

Combination of TRAP1 and ERCC1 Expression Predicts Clinical Outcomes in Metastatic Colorectal Cancer Treated with Oxaliplatin/5-Fluorouracil 한재훈, 백선경, 이재진, 김고영, 김시영, 이석환 pp.55-64

Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3 김희정, 임가원, 남은지, 김영태 pp.81-92

Primary Follicular Lymphoma in a Male Breast : A Case Report 정승필, 한광민, 김석진, 남석진, 배정원, 이정언 pp.104-107

Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy 이수임, 장은덕, 나세정, 김정수, 안호정, 고윤호, 원혜성 pp.98-103

Clinical Implications of Systemic Inflammatory Response Markers as Independent Prognostic Factors in Colorectal Cancer Patients 백광열, 이인규, 이윤석, 성나영, 권택수 pp.65-73

New Systems Introduced for the Betterment of Our Journal 김일한 pp.1-1

Chemotherapy in Advanced Gastric Cancer Patients Associated with Disseminated Intravascular Coagulation 황인규, 최진화, 박세훈, 오성용, 권혁찬, 이순일, 임도형, 이경원, 강정훈 pp.27-32

A Distribution Weighted Prognostic Scoring Model for Node Status in Advanced Rectal Cancer 여광희, 김호현, 김동이, 김영진, 주재균 pp.41-47

Dose KRAS Mutation Status Affect on the Effect of VEGF Therapy in Metastatic Colon Cancer Patients? 김승태, 박경화, 신상원, 김열홍 pp.48-54

A Randomized Double-Blind, Double-Dummy, Multicenter Trial of Azasetron versus Ondansetron to Evaluate Efficacy and Safety in the Prevention of Delayed Nausea and Vomiting Induced by hemotherapy 이희연, 김훈교, 이경희, 김봉석, 송홍석, 양성현, 김준희, 김열홍, 김종광, 김상위, 김시영, 박희숙 pp.19-26

The Role of Radiotherapy in the Treatment of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma 남택근, 안재숙, 최유덕, 정재욱, 김용협, 윤미선, 안성자, 정웅기 pp.33-40

Adenoid Cystic Carcinoma of the Breast : A Case Series of Six Patients and Literature Review 김미소, 이대원, 임진, 서경진, 김범석, 문형곤, 임석아, 한원식, 박인애, 노동영 pp.93-97

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Rankings and symptom assessments of side effects from chemotherapy: insights from experienced patients with ovarian cancer 네이버 미소장
2 Comparison of Ramosetron and Granisetron for the Prevention of Acute and Delayed Emesis in Cisplatin-Based Chemotherapy: a Randomized Controlled Trial 네이버 미소장
3 Comparison of Azasetron and Ondansetron for Preventing Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery 소장
4 Navari RM. Pathogenesis-based treatment of chemotherapyinduced nausea and vomiting: two new agents. J Support Oncol. 2003;1:89-103. 미소장
5 [High affinity binding of Y-25130 for serotonin 3 receptor]. 네이버 미소장
6 [Pharmacokinetics of azasetron (Serotone), a selective 5-HT3 receptor antagonist]. 네이버 미소장
7 [Comparison of ramosetron and azasetron for prevention of acute and delayed cisplatin-induced emesis in lung cancer patients]. 네이버 미소장
8 [Clinical effect of two azasetron treatment methods against nausea and vomiting induced by anticancer drugs including CDDP]. 네이버 미소장
9 Proposal for classifying the acute emetogenicity of cancer chemotherapy. 네이버 미소장
10 Synthesis of 5-HT3 receptor antagonists, [11C]Y-25130 and [11C]YM060. 네이버 미소장
11 Dose‐independent pharmacokinetics of ondansetron in rats: contribution of hepatic and intestinal first‐pass effects to low bioavailability 네이버 미소장
12 Concentration of ondansetron in cerebrospinal fluid following oral dosing in volunteers. 네이버 미소장
13 Effects of 5-HT 3 receptor antagonists on models of acute and delayed emesis induced by cisplatin in the ferret 네이버 미소장
14 Should 5-hydroxytryptamine-3 receptor antagonists be administered beyond 24 hours after chemotherapy to prevent delayed emesis? Systematic re-evaluation of clinical evidence and drug cost implications. 네이버 미소장
15 The effects of orally administered Y-25130, a selective serotonin3-receptor antagonist, on chemotherapeutic agent-induced emesis. 네이버 미소장
16 [Analysis of antiemetic effect of various dosage regimens of azasetron hydrochloride based on 5-HT3 receptor occupancy of serotonin]. 네이버 미소장
17 Review of the preclinical pharmacology and comparative efficacy of 5-hydroxytryptamine-3 receptor antagonists for chemotherapy-induced emesis. 네이버 미소장
18 [A randomized crossover comparison of azasetron and granisetron in the prophylaxis of emesis induced by chemotherapy including cisplatin]. 네이버 미소장
19 [Study on clinical effect of a continuous intravenous infusion of azasetron against nausea and vomiting induced by anticancer drugs including CDDP]. 네이버 미소장
20 Comparative Clinical Trial of Granisetron and Ondansetron in the Prophylaxis of Cisplatin-Induced Emesis 네이버 미소장
21 Use of dexamethasone and granisetron in the control of delayed emesis for patients who receive highly emetogenic chemotherapy. National Cancer Institute of Canada Clinical Trials Group. 네이버 미소장
22 The role of the 5-HT3 antagonists ondansetron and dolasetron in the control of delayed onset nausea and vomiting in patients receiving moderately emetogenic chemotherapy. 네이버 미소장
23 Dexamethasone Alone or in Combination with Ondansetron for the Prevention of Delayed Nausea and Vomiting Induced by Chemotherapy 네이버 미소장
24 Potential of substance P antagonists as antiemetics. 네이버 미소장
25 Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets. 네이버 미소장

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