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동의어 포함
Bone marrow stromal cell(BMC) is an attractive source for myocardial repair, however, its poor homing rate to injured lesion is one of the critical limitations. Simvastatin has been interested as a pleiotrophic effects besides its cholesterol-lowering effect on cardiovascular disease. We investigated whether simvastatin and simvastatin/
ezetimibe(Simvastatin/Ezetimibe) affect on BMCs’ homing in myocardial schemia/reperfusion(I/R) injury rat model. Rats were divided into three groups, and received drinking water(DW), simvastatin(1.67 mg/kg/d) or simvastatin/ ezetimibe (1.67 mg/kg/d) by gastric gavage 1 day before I/R injury, and then continued for 7 days. I/R injury model was induced by ligation of left anterior descending coronary artery for 4 hours followed by release and conducted BMCs transplantation through tail vein injection containing 1×106 BMCs infected with firefly luciferaseencoding adenovirus. After BMCs transplantation, optical bioluminescence imaging was obtained to determine the
cell homing rate. The bioluminescence was higher in both simvastatin- and simvastatin/ezetimibe groups than in DW group. Luciferase activity from left ventricle extract was higher both in simvastatin and simvastatin/ezetimibe group than in DW group. There was no significant difference between simvastatin and simvastatin/ezetimibe groups.
These results suggest that simvastatin might be a useful reagent for improving homing rate of systemically administered BMCs for cardiac repair.| 번호 | 참고문헌 | 국회도서관 소장유무 |
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| 13 | Viral Vector–mediated and Cell-based Therapies for Treatment of Cystic Fibrosis ![]() |
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| 23 | Statin and stromal cell-derived factor-1 additively promote angiogenesis by enhancement of progenitor cells incorporation into new vessels. ![]() |
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| 24 | Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase ![]() |
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