본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색
결과 내 검색 동의어 포함
결과 내 검색 동의어 포함

-

초록보기

Overweight and obesity are usually related with high fat and calorie intake, and seriously causative of lifestyle-related diseases such as cardiovascular disorders, arteriosclerosis, and colon cancer. In this study,we propose a novel dietary therapy against overweight and obesity using mixtures of protamine and chitooligosaccharide (COS), which are known to interrupt the lipid metabolism in the body. Protamine is a dietary protein originated from salmon reproductive organ, and COS is an oligosaccharide made from chitin or chitosan by chemical or enzymatic hydrolysis. In the enzyme activity analysis in vitro, protamine and COS strongly suppressed the activity of pancreatic lipase, which is the primary enzyme for the digestion and absorption of lipids in the intestine. In in vivo animal test, the mixtures of protamine and COS significantly reduced the serum levels of triglyceride (TG), total cholesterol (T-CHO), and low density lipoprotein-cholesterol (LDLC) and inhibited the accumulation of lipids in liver tissue of Sprague Dawley (SD) rats fed high fat diets. On the other hand, they increased fecal TG and T-CHO contents. From these alterations in lipid metabolism, we verified that protamine and COS mixtures could effectively interrupt the digestion and absorption of dietary lipids in the body by inhibiting pancreatic lipase activity. In addition, protamine and COS mixtures increased the serum level of high density lipoprotein-cholesterol (HDLC), responsible for removing cholesterol from cells and protecting atherosclerosis, and therefore decreased the potential risks of cardiovascular diseases by lowering values of the atherogenic index (AI)and cardiac risk factor (CRF). Taken together, we suggest protamine and COS mixtures as a prominent dietary therapy for the prevention of overweight, obesity, and further cardiovascular diseases related with hyperlipidemia.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Differential expression of caveolins and myosin heavy chains in response to forced exercise in rats Sookyoung Park, Yunkyung Hong, Youngjeon Lee, Jinyoung Won, Kyu-Tae Chang, Yonggeun Hong pp.1-9

Spermatotoxic effects of α-chlorohydrin in rats Sung-Hwan Kim, In-Chul Lee, Jeong-Hyeon Lim, Changjong Moon, Chun-Sik Bae, Sung-Ho Kim, Dong-Ho Shin, Hyoung-Chin Kim, Jong-Choon Kim pp.11-16

A comparative study of the effects of topical application of Aloe vera, thyroid hormone and silver sulfadiazine on skin wounds in wistar rats Mahsa Tarameshloo, Mohsen Norouzian, Saeed Zarein-Dolab, Masoomeh Dadpay, Roohollah Gazor pp.17-21

Anti-obesity and anti-diabetic effects of yerba mate(ilex paraguariensis) in C57BL/6J mice fed a high-fat diet Young-Rye Kang, Hak-Yong Lee, Jung-Hoon Kim, Dea-In Moon, Min-Young Seo, Sang-Hoon Park, Kwang-Ho Choi, Chang-Ryong Kim, Sang-Hyun Kim, Ji-Hyun Oh … [et al.] pp.23-29

Modulation of lipid metabolism by mixtures of protamine and chitooligosaccharide through pancreatic lipase inhibitory activity in a rat model Nam-Hee Kang, Won Kyung Lee, Bo-Rim Yi, Min-Ah Park, Hye-Rim Lee, Sang-Ki Park, Kyung-A Hwang, Hyoung Kook Park, Kyung-Chul Choi pp.31-38

Anti-hypercholesterolemic and anti-atherosclerotic effects of polarized-light therapy in rabbits fed a high-cholesterol diet Dongsun Park, Jangbeen Kyung, Dajeong Kim, Seock-Yeon Hwang, Ehn-Kyoung Choi, Yun-Bae Kim pp.39-46

Beneficial effects of melatonin on stroke-induced muscle atrophy in focal cerebral ischemic rats Seunghoon Lee, Jinhee Shin, Yunkyung Hong, Minkyung Lee, Koo Kim, Sang-Rae Lee, Kyu-Tae Chang, Yonggeun Hong pp.47-54

Anti-helicobacter pylori effects of IgY from egg york of immunized hens Yun-Hui Yang, Dongsun Park, Goeun Yang, Sun Hee Lee, Dae Kwon Bae, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Jae-Cheol Son, Seock-Yeon Hwang … [et al.] pp.55-60

Molecular identification of mycoplasma cynos from laboratory beagle dogs with respiratory disease Sunhwa Hong, Okjin Kim pp.61-66

Adiaspiromycosis of an apodemus agrarius captured wild rodent in Korea Tae-Hyoun Kim, Ju-Hee Han, Seo-Na Chang, Dong-Su Kim, Tamer Said Abdelkader, Seung-Hyeok Seok, Jong-Hwan Park, Hong-Shik Oh, Jong-Taek Kim, Byoung-Hee Lee … [et al.] pp.67-69

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Effect of increasing body weight on morbidity and mortality in South Korea. 네이버 미소장
2 Low cholesterol is associated with mortality from cardiovascular diseases : a dynamic cohort study in Korean adults 소장
3 Effect of dietary protamine on lipid metabolism in rats 소장
4 The antibacterial action of protamine: evidence for disruption of cytoplasmic membrane energization in Salmonella typhimurium 네이버 미소장
5 Effect of protamine in obesity induced by high-fat diets in rats 네이버 미소장
6 Influence of molecular weight on oral absorption of water soluble chitosans 네이버 미소장
7 Effects of chitooligosaccharide supplementation on performance, blood characteristics, relative organ weight, and meat quality in broiler chickens 네이버 미소장
8 In vitro antimicrobial activity of a chitooligosaccharide mixture against Actinobacillus actinomycetemcomitans and Streptococcus mutans 네이버 미소장
9 Inhibition of polyamine biosynthesis in Acanthamoeba castellanii and 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by chitosanoligosaccharide. 네이버 미소장
10 Effects of chitooligosaccharide lactate salt on sleep deprivation-induced fatigue in mice. 네이버 미소장
11 Antidiabetic action of low molecular weight chitosan in genetically obese diabetic KK-Ay mice. 네이버 미소장
12 Tang ZR, Yin YL, Nyachoti CM, Huang RL, Li TJ, Yang C, Yang XJ, Gong J, Peng J, Qi DS, Xing JJ, Sun ZH, Fan MZ. Effect of dietary supplementation of chitosan and galacto-mannanoligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets. Domest Anim Endocrinol 2005; 28(4): 430-441. 미소장
13 Chitooligosaccharides decreases plasma lipid levels in healthy men. 네이버 미소장
14 Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. 네이버 미소장
15 Pancreatic lipase inhibitory activity of taraxacum officinale in vitro and in vivo 소장
16 Studies on the inhibition of pancreatic and carboxylester lipases by protamine. 네이버 미소장
17 Technical note: Milk composition in mice—Methodological aspects and effects of mouse strain and lactation day 네이버 미소장
18 Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol A using microarray analysis 소장
19 Yi BR, Kang NH, Hwang KA, Kim SU, Jeung EB, Choi KC. Antitumor therapeutic effects of cytosine deaminase and interferon-β against endometrial cancer cells using genetically engineered stem cells in vitro. Anticancer Res 2011; 31(9): 2853- 2861. 미소장
20 Effects of dietary fish protein on serum and liver lipid concentrations in rats and the expression of hepatic genes involved in lipid metabolism. 네이버 미소장
21 Soybean beta-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of beta-oxidation, downregulation of fatty acid synthase, and inhibition of triglyceride absorption. 네이버 미소장
22 Molecular mechanisms of rat and human pancreatic triglyceride lipases. 네이버 미소장
23 The triglyceride lipases of the pancreas. 네이버 미소장
24 Artenie R, Ungureanu D, Artenie A, Botnariu G, Anisie E. [HDLcholesterol-- active or passive participant in the pathogenesis of atherosclerosis]. Rev Med Chir Soc Med Nat Iasi 2003; 107(2): 282-287. 미소장
25 Observational study of lipid profile and LDL particle size in patients with metabolic syndrome. 네이버 미소장

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차