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Purpose: To investigate temporal changes in IL-1β mRNA expression in spinal dorsal horn (DH) and dorsal root ganglion

(DRG) in a rat lumbar disc herniation (LDH) model.

Methods: Autologous nucleus pulposus, harvested from the tail disc between the second and third coccygeal vertebrae

(Co2-3), was implanted next to the left L5 nerve root just proximal to the DRG after partial laminectomy. IL-1β mRNA

expression was investigated in DRG and DH in our LDH model. Real-time PCR assays were done using a 7500 Real Time PCR

system (Applied Biosystems, USA).

Results: Expression of IL-1β in DRG and DH was observed for 30 days postoperatively. Expression of IL-1β mRNA in the

ipsilateral DRG of the LDH group gradually increased from 5 to 30 days after surgery. The amount of IL-1β in the contralateral

DRG peaked 10 days after surgery and then gradually decreased. However, there was no difference in IL-1β mRNA expression

in spinal DH between the LDH group and the sham-operated group.

Conclusion: Long-term expression of IL-1β in the LDH model may worsen the chronic pain state. Future studies on inhibition

of IL-1β expression in the LDH model will be needed to develop selective treatment strategies for patients with LDH.

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기사명 저자명 페이지 원문 목차
Motor Function Recovery in Stroke Patients with Corona Radiata Infarct : 4 Case Studies Chung-Sun Kim, Jung-Won Kwon p.31-35

Effects of Spinal Stabilization Exercises on the Cross-sectional Areas of the Lumbar Multifidus and Psoas Major Muscles of Patients with Degenerative Disc Disease Seong-Ho Kim, Wan-Hee Lee p.9-15

A Study on the Distribution of Plantar Pressure in Adult Hemiplegia during Gait with the Use of Cane Yong-Jun Cha, Kyoung Kim p.49-53

Effects of Specific Exercise on Chronic Neck Pain in Elderly Women Sang-Hee Shin, Jong-Duk Choi p.1-8

Correlation between the Pressure Pain Threshold and Sonography and Spontaneous Electrical Activity in Myofascial Trigger Points Hyun-Jin Kim, Myung-Hoon Kim, Su-Hyon Kim, Seok Oh, Ji-Ho Choi, Tae-Youl Kim p.17-21

Functions (Mobility, Self-care, Social Ability) and Health-related Quality of Life in Children with Cerebral Palsy Joo-Yeon Ko, Suk-Min Lee p.37-44

The Effect of a Balance Training Program to Improve the Balance of Aged Patients with Diabetes Mellitus Yong-Woo Lee, Se-Jong Choi, Chang-Ho Song p.23-30

Neurophysiological and Clinical Features of the Pusher Syndrome : Review Article Chung-Sun Kim, Seok-Hyun Nam p.45-48

The Effects of Water Exercise Program on Pennation Angle of the Lower Limb Muscle with Women in Their 20’s Hwa-Young Cho, Moon-Jung Kim, Se-Won Yoon p.55-59

Correlations of Physical Fitness Factors, Antioxidant Enzymes, Lipid Peroxidation, Lipid Profiles, Lactate Levels and Cardiovascular Variables in an Exercising Group and Controls Jae-Ho Yu, Suk-Min Lee p.61-69

Expression of TRPV1 and iNOS in the Dorsal Root Ganglion Exposed by Autologous Nucleus Pulposus in the Rat Su-Jeong Kim, Jeong-Min Seo, Yun-Woo Cho, Hea-Woon Park, Joon-Ha Lee, Se-Jin Hwang, Sang-Ho Ahn p.71-77

Effect of Stem Cell Transplantation on Pain Behavior and Locomotor Function in Spinal Cord Contusion Model Hea-Woon Park, Su-Jeong Kim, Yun-Woo Cho, Se-Jin Hwang, Won-Yub Lee, Sang-Ho Ahn, Sung-Ho Jang p.79-85

Electrical Stimulation Induces the Collagen Deposition and TGF-β1 mRNA Expression in Skin Wound of Rat Jae-Hyoung Lee, Chan-Eui Park, Rae-Joon Park p.87-92

Development of Neuropathic Pain Behavior and Expression of CCL2/CCR2 and CX3CL1/CX3CR1 after Spinal Cord Hemisection Hea-Woon Park, Jo-Young Son, Yun-Woo Cho, Se-Jin Hwang, Su-Jeong Kim, Sang-Ho Ahn, Sung-Ho Jang, Yong-Jae Jung p.99-105

Temporal Expression of Interleukin-1β in the Dorsal Root Ganglion in a Rat Model of Lumbar Disc Herniation Su-Jeong Kim, Hee-Jin Gu, Yun-Woo Cho, Hea-Woon Park, Joon-Ha Lee, Se-Jin Hwang, Sang-Ho Ahn p.93-98

참고문헌 (36건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Takahashi H, Suguro T, Okazima Y et al. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine (Phila Pa 1976). 1996;21(2):218-24. 미소장
2 The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. 네이버 미소장
3 Ahn SH, Cho YW, Ahn MW et al. mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine (Phila Pa 1976). 2002;27(9):911-7. 미소장
4 mRNA expression of interleukins, phospholipase A2, and nitric oxide synthase in the nerve root and dorsal root ganglion induced by autologous nucleus pulposus in the rat 네이버 미소장
5 Effects of interleukin-1 beta, interleukin-6, and tumor necrosis factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats 네이버 미소장
6 Dorsal root sensitivity to interleukin-1 beta, interleukin-6 and tumor necrosis factor in rats 네이버 미소장
7 Aoki Y, Rydevik B, Kikuchi S et al. Local application of disc-related cytokines on spinal nerve roots. Spine (Phila Pa 1976). 2002;27(15):1614-7. 미소장
8 Kawakami M, Tamaki T, Hashizume H et al. The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat. Spine (Phila Pa 1976). 1997;22(10):1074-9. 미소장
9 Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α 네이버 미소장
10 Correlation between inflammatory cytokines released from the lumbar facet joint tissue and symptoms in degenerative lumbar spinal disorders 네이버 미소장
11 Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P. 네이버 미소장
12 Distribution of interleukin 1β immunoreactivity within the porcine hypothalamus 네이버 미소장
13 Interleukin-1beta immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: evidence for activity-dependent release. 네이버 미소장
14 Expression of interleukin-1 beta in rat dorsal root ganglia 네이버 미소장
15 The role of IL-6 and IL-1β in painful perineural inflammatory neuritis 네이버 미소장
16 Cho YW, Park HW, Kim SJ et al. Expression of MCP‐ in spinal dorsal horn in a rat model of lumbar disc herniation. J Kor Soc Phys Ther. 2009;21(3):95-102. 미소장
17 Doita M, Kanatani T, Harada T et al. Immunohistologic study of the ruptured intervertebral disc of the lumbar spine.Spine (Phila Pa 1976). 1996;21(2):235-41. 미소장
18 Cytokines in acute and chronic inflammation. 네이버 미소장
19 Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. 네이버 미소장
20 Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat 네이버 미소장
21 The Long-Lasting Pattern of the Neuropathic Radicular Pain in An Autologous Nucleus Pulposus Model of Rat 소장
22 The role of enhanced cutaneous IL-1beta signaling in a rat tibia fracture model of complex regional pain syndrome. 네이버 미소장
23 The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study. 네이버 미소장
24 Spontaneous secretion of interleukin 1 receptor antagonist (IL-1ra) by cells isolated from herniated lumbar discal tissue after discectomy. 네이버 미소장
25 Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury. 네이버 미소장
26 Myers RR, Campana WM, Shubayev VI. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov Today. 2006;11(1-2):8-20. 미소장
27 Kiguchi N, Maeda T, Kobayashi Y et al. Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation. Pain. 149(2):305-15. 미소장
28 Yoshida M, Nakamura T, Sei A et al. Intervertebral disc cells produce tumor necrosis factor alpha, interleukin-1beta, and monocyte chemoattractant protein-1 immediately after herniation:an experimental study using a new hernia model.Spine (Phila Pa 1976). 2005;30(1):55-61. 미소장
29 Cytokine-to-brain communication: A review & analysis of alternative mechanisms 네이버 미소장
30 Effect of interleukin-1beta on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function. 네이버 미소장
31 Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. 네이버 미소장
32 Takebayashi T, Cavanaugh JM, Cuneyt Ozaktay A et al.Effect of nucleus pulposus on the neural activity of dorsal root ganglion. Spine (Phila Pa 1976). 2001;26(8):940-5. 미소장
33 Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved 네이버 미소장
34 The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice. 네이버 미소장
35 Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation 네이버 미소장
36 Spinal interleukin‐1β in a mouse model of arthritis and joint pain 네이버 미소장

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