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Background: There is limited understanding of the effect of dietary components on the absorption ofginsenosides and their metabolites into the blood.

Methods: This study investigated the pharmacokinetics of the ginseng extract and its main constituentginsenoside Rb1 in rats with or without pretreatment with a prebiotic fiber, NUTRIOSE, by liquidchromatography tandem mass spectrometry. When ginsenoside Rb1 was incubated with rat feces, itsmain metabolite was ginsenoside Rd.

Results: When the intestinal microbiota of rat feces were cultured in vitro, their ginsenoside Rd-formingactivities were significantly induced by NUTRIOSE. When ginsenoside Rb1 was orally administered torats, the maximum plasma concentration (Cmax) and area under the plasma drug concentrationetimecurve (AUC) for the main metabolite, ginsenoside Rd, were 72.4 31.6 ng/mL and 663.9 285.3 mg$h/mL, respectively. When the ginseng extract (2,000 mg/kg) was orally administered, Cmax and AUC forginsenoside Rd were 906.5 330.2 ng/mL and 11,377.3 4,470.2 mg$h/mL, respectively. When ginsengextract was orally administered to rats fed NUTRIOSE containing diets (2.5%, 5%, or 10%), Cmax and AUCwere increased in the NUTRIOSE receiving groups in a dose-dependent manner.

Conclusion: These findings reveal that intestinal microflora promote metabolic conversion of ginsenosideRb1 and ginseng extract to ginsenoside Rd and promote its absorption into the blood in rats. Its conversionmay be induced by prebiotic diets such as NUTRIOSE.

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기사명 저자명 페이지 원문 목차
Effect of a soluble prebiotic fiber, NUTRIOSE, on the absorption of ginsenoside Rd in rats orally administered ginseng Kyung-Ah Kim, Hye Hyun Yoo, Wan Gu, Dae-Hyung Yu, Ming Ji Jin, Hae-Lim Choi, Kathy Yuan, Laetitia Guerin-Deremaux, Dong-Hyun Kim pp.203-207

Biological control of Colletotrichum panacicola on Panax ginseng by Bacillus subtilis HK-CSM-1 Hojin Ryu, Hoon Park, Dong-Sang Suh, Gun Ho Jung, Kyungseok Park, Byung Dae Lee pp.215-219

A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases Chang Ho Lee, Jong-Hoon Kim pp.161-166

Effects of Korean Red Ginseng(Panax ginseng), urushiol(Rhus vernicifera Stokes), and probiotics(Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the guteliver axis of alcoholic liver disease Chang Seok Bang, So Hyung Hong, Ki Tae Suk, Jin Bong Kim, Sang Hak Han, Hotaik Sung, Eun Ji Kim, Myoung Jo Kim, Moon Young Kim, Soon Koo Baik, Dong Joon Kim pp.167-172

Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3 Jae-Hyoung Song, Hwa-Jung Choi, Hyuk-Hwan Song, Eun-Hye Hong, Bo-Ra Lee, Sei-Ryang Oh, Kwangman Choi, Sang-Gu Yeo, Yong-Pyo Lee, Sungchan Cho pp.173-179

Changes in ginsenoside compositions and antioxidant activities of hydroponic-cultured ginseng roots and leaves with heating temperature Cho Rong Hwang, Sang Hoon Lee, Gwi Yeong Jang, In Guk Hwang, Hyun Young Kim, Koan Sik Woo, Junsoo Lee, Heon Sang Jeong pp.180-186

Discrimination of white ginseng origins using multivariate statistical analysis of data sets Hyuk-Hwan Song, Ji Young Moon, Hyung Won Ryu, Bong-Soo Noh, Jeong-Han Kim, Hyeong-Kyu Lee, Sei-Ryang Oh pp.187-193

Complete 1H-NMR and 13C-NMR spectral analysis of the pairs of 20(S) and 20(R) ginsenosides Heejung Yang, Jeom Yong Kim, Sun Ok Kim, Young Hyo Yoo, Sang Hyun Sung pp.194-202

Korean Red Ginseng saponin fraction modulates radiation effects on lipopolysaccharide-stimulated nitric oxide production in RAW264.7 macrophage cells Young Ji Lee, Jeong Yoon Han, Chang Geun Lee, Kyu Heo, Se Il Park, Yoo Soo Park, Joong Sun Kim, Kwang Mo Yang, Ki-Ja Lee, Tae-Hwan Kim pp.208-214

Plant regeneration of Korean wild ginseng(Panax ginseng Meyer) mutant lines induced by g-irradiation(60Co) of adventitious roots Jun-Ying Zhang, Hyeon-Jin Sun, In-Ja Song, Tae-Woong Bae, Hong-Gyu Kang, Suk-Min Ko, Yong-Ik Kwon, Il-Woung Kim, Jaechun Lee, Shin-Young Park pp.220-225

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