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국회도서관 홈으로 정보검색 소장정보 검색

초록보기

Objectives : The purpose of this study was verification of the restoration ability effect of Danggwisusan extract(DG) in wound induced Rat.

Methods : It needed to make a scar(around 2×2㎠) on the top of the fascia in the back of the rats and then the rats were divided into 4groups(n=6). Control was not treated at all, where as DG was orally medicated DG, Terra was percutaneously applied Terramycin, and DG+Terra was both orally medicated DG and percutaneously applied Terramycin per day for three weeks.

Results : 93% or higher cell viability was observed in all tested groups from 1, 10, 100 ㎍/㎖ in RAW 264.7cells. The DG decreased NO and cytokine production activity dose dependently. The production of IL-1β, IL-6 and TNF-α were decreased by 46%, 46% and 40% in DG treated 100 ㎍/㎖. The size of wound was significantly decreasing in DG, Terra, DG+Terra. WBC was significantly reduced in DG and DG+Terra. Monocyte was significantly reduced in DG, Terra and DG+Terra. Neutrophil was also reduced in DG, DG+Terra but not meaningless. The mRNA expression of MMP-1 was significantly reduced in Terra, MMP-2 was significantly reduced in DG, Terra, DG+Terra, and MMP-9 was significantly reduced in DG+Terra.

Conclusions : According to the results, we thought that DG showed anti-inflammatory activities on the RAW 264.7cells in mouse macrophage and in adult rat wound. Moreover, the progress of recovery was found visually, heamatologically, genetically and histopathologically. In conclusion, it could be thought that DG has effect on the treating of wound.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
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참고문헌 (30건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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19 Macrophage responses to hypoxia: relevance to disease mechanisms. 네이버 미소장
20 Sequential appearance of fibronectin and collagen in experimental granulation tissue. 네이버 미소장
21 Cutaneous wound healing: A model for cell-matrix interactions 네이버 미소장
22 Choi WH, Oh YS, Ahn JY, Kim SR, Ha TY. Antioxidative and Protective Effects of Ulmus davidiana var. japonica Extracts on Glutamate-Induced Cytotoxicity in PC 12 Cells. Korean Soc Food Sci Technol. 2005 ; 37(3) : 479-83. 미소장
23 Effect of Fermented Epimedii Herba Extract on the Immuno modulating Activity 소장
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29 Differential Expression of Matrix Metalloproteinases and Their Tissue-Derived Inhibitors in Cutaneous Wound Repair 네이버 미소장
30 Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. 네이버 미소장