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Objectives : The purpose of this study was verification of the restoration ability effect of Danggwisusan extract(DG) in wound induced Rat.
Methods : It needed to make a scar(around 2×2㎠) on the top of the fascia in the back of the rats and then the rats were divided into 4groups(n=6). Control was not treated at all, where as DG was orally medicated DG, Terra was percutaneously applied Terramycin, and DG+Terra was both orally medicated DG and percutaneously applied Terramycin per day for three weeks.
Results : 93% or higher cell viability was observed in all tested groups from 1, 10, 100 ㎍/㎖ in RAW 264.7cells. The DG decreased NO and cytokine production activity dose dependently. The production of IL-1β, IL-6 and TNF-α were decreased by 46%, 46% and 40% in DG treated 100 ㎍/㎖. The size of wound was significantly decreasing in DG, Terra, DG+Terra. WBC was significantly reduced in DG and DG+Terra. Monocyte was significantly reduced in DG, Terra and DG+Terra. Neutrophil was also reduced in DG, DG+Terra but not meaningless. The mRNA expression of MMP-1 was significantly reduced in Terra, MMP-2 was significantly reduced in DG, Terra, DG+Terra, and MMP-9 was significantly reduced in DG+Terra.
Conclusions : According to the results, we thought that DG showed anti-inflammatory activities on the RAW 264.7cells in mouse macrophage and in adult rat wound. Moreover, the progress of recovery was found visually, heamatologically, genetically and histopathologically. In conclusion, it could be thought that DG has effect on the treating of wound.기사명 | 저자명 | 페이지 | 원문 | 목차 |
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LPS로 유발된 우울증에 대한 甘草의 효과 | 고성렬, 김도훈, 이태희 | pp.9-16 | ||
傷寒論의 葱白 기원과 1 일 복용량 | 김인락 | pp.39-43 | ||
加味桂芍知母湯 주정 추출물이 류마티스 관절염 인자에 미치는 영향 | 심부용, 박지원, 김동희 | pp.65-73 | ||
導痰湯이 고지혈증 흰쥐의 뇌허혈 손상에 미치는 영향 | 김경훈, 김도훈, 김연섭 | pp.23-30 | ||
生肝健脾湯加味方을 이용한 갑상선기능저하증 치험1例 | 구진숙, 김봉현, 서부일 | pp.17-21 | ||
黃連 추출물의 항염효능에 관한 연구 | 이전우, 한효상, 이영종 | pp.83-90 | ||
鼻皮 증류액의 항균, 소염, 항산화 작용에 대한 연구 | 김호선, 이영종 | pp.45-53 | ||
갈근이 고지방·고탄수화물식이와 저용량 streptozotocin-유도 당뇨병 마우스에 미치는 효능 연구 | 오태우, 박용기 | pp.75-81 | ||
당귀수산(當歸鬚散) 주정 추출물이 외상성 창상(外傷性 創傷) 병태모델의 회복능력에 미치는 영향 | 박지원, 심부용, 김동희 | pp.55-63 | ||
백선 추출물의 간세포 손상에 대한 연구 | 하헌용 | pp.91-95 | ||
본초 귀경에 따른 상소한약의 당내성 유발 마우스에서의 개선 효능 비교 연구 | 강석용, 박용기 | pp.1-8 | ||
저칼슘 식이로 유발한 성장 저하 흰쥐에 대한 칼슘, 비타민 D 및 난황 펩타이드의 투여가 장골 길이 성장에 미치는 영향 | 김명규, 김혜경, 임강현 | pp.31-38 |
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