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Saccharin is a commonly used artificial sweetener in foodstuffs. However, for its carcinogenic dispute, it has been regulated by government bodies. In this study, isotope dilution mass spectrometry (ID-MS) was introduced for the accurate quantification of saccharin. To employ ID-LC/MS, we obtained its isotope analogue, 13C1-sodium saccharin, by customized synthesis. Samples were spiked with 13C1-sodium saccharin and analyzed with LC/MS in negative mode. Chromatographic conditions were optimized for the adequate chromatographic retention and separation of saccharin with a C18 column. MS was operated with electrospray ionization by the selected ion monitoring (SIM) mode of [M - H]- for saccharin (m/z 182) and [M - Na]- for its isotope analogue (m/z 183). To validate the ID-LC/MS method for accurate measurement, we prepared a batch of a candidate material by sortifying quasi-tea-drinks with saccharin and analyzed samples gravimetrically fortified in various levels of concentration. The repeatability and reproducibility of this method was tested by analyzing the reference material. Result show that ID-LC/MS is a reliable method for the quantitative analysis of saccharin.

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기사명 저자명 페이지 원문 목차
Effective Analysis of Dicyclanil in Lamb and Chicken Muscle using HPLCUV/ Vis and LC/MS/MS ByungJu Kim, Seung-Woon Myung pp.45-48
Mass spectrometric studies of competitive binding of C60 and C70 to mesosubstituted porphyrins Sunghan Jung, SeungKoo Shin pp.49-52
Validation and Applications of Gas Chromatography-Combustion/isotope Ratio Mass Spectrometric Method to Control Misuse of Androgens in Human Kang Mi Lee, Ho Jun Kim, Eun Sook Jeong, Hye Hyun Yoo, Oh-Seung Kwon, Changbae Jin pp.33-36
Accurate Quantification of Saccharin Using Isotope Dilution Liquid Chromatography Mass Spectrometry(ID-LC/MS) Yunjung Lee, 김병주, 김정권, 안성희 pp.37-40
Enrichment of Peptides using Novel C8-functionalized Magnetic Nanoparticles for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Analysis Sunmi Song, Hyo-Jik Yang, Jin Hee Kim, Seongjae Shin, Eun Hye Park, 김정권 pp.53-56
Introduction of Taiwan Society for Mass Spectrometry Jentaie Shiea pp.29-32
Determination of the Uranium Backgrounds in Lexan Films for Single Particle Analysis using FT-TIMS technique Sujin Park, Jong-Ho Park, Myung Ho Lee, Kyuseok Song pp.57-60
Compositional Characterization of Petroleum Heavy Oils Generated from Vacuum Distillation and Catalytic Cracking by Positive-mode APPI FT-ICR Mass Spectrometry Eunkyoung Kim, Myoung-han No, 고재석, Sungwhan Kim pp.41-44

참고문헌 (20건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Remsen, I.; Fahlberg, C. Am. Chem. J. 1879, 1, 426. 미소장
2 Toxicology evaluation of poison oak urushiol and its esterified derivative 네이버 미소장
3 Oser, B. L. Fd. Chem. Toxic. 1985, 23, 535. 미소장
4 Bryan, G. T.; Erturk, E.; Yoshida, O. Science 1970, 168, 1238. 미소장
5 Holder, C.L.; Bowman, M.C. Toxicol. Lett. 1980, 5, 27. 미소장
6 Chromatography of plasmid DNA 네이버 미소장
7 Chromatography in Turkey 네이버 미소장
8 Di Pietra, A. M.; Cavrini, V.; Bonazzi, D.; Benfenati, L. Chromatographia 1990, 30, 215. 미소장
9 Tyler, T. A. J. Assoc. Off. Anal. Chem. 1984, 67, 745. 미소장
10 Chromatography of plasmid DNA 네이버 미소장
11 Lho, D. S.; Hong, J. K.; Paek, H. K.; Lee, J. A. J. Anal. Toxicol. 1990, 14, 77. 미소장
12 Chromatography today : By C.F. Poole and S.K. Poole, Elsevier, Amsterdam, 1991, XI + 1026 pp., price US$ 147.50, Dfl. 295.00, ISBN 0-444-88492-0. 네이버 미소장
13 Chromatography in the petroleum industry: Journal of Chromatography Library Series No. 56, edited by E.R. Adlard, Elsevier, Amsterdam, Lausanne, New York, Oxford, Shannon, Tokyo, 1994 XVIII + 434 pp., price Dfl. 435.00, ISBN 0-444-89776-3 네이버 미소장
14 Chromatographic separation of α-pinene isomerization products 네이버 미소장
15 Koyama, M.; Yoshida, K.; Uchibori, N.; Wada, I.; Akiyama, K.; Sasaki, T. J. Food Hyg. Soc. Japan 2005, 46, 72. 미소장
16 Yang, D.-J.; Chen, B. J. Agric. Food Chem. 2009, 57, 3022. 미소장
17 Chromatographic analysis. Foreword. 네이버 미소장
18 Lee, I.; Ahn, S.; Kim, B.; Hwang, E.; Kim, Y.-S. Bull. Korean Chem. Soc. 2008, 29, 2125. 미소장
19 Park, S.; Kim, B.; So, H.-Y.; Kim, Y.-J.; Kim, J. Bull. Korean Chem. Soc. 2007, 28, 737. 미소장
20 Kim, B.; Park, S.; Lee, I.; Lim, Y.; Hwang, E.; So, H.-Y. Anal. Bioanal. Chem. 2010, 398, 1035. 미소장

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