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한국학술지인용색인(NRF)
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Bone destruction is a pathological symptom of some chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of these diseases results from increased number and activity of osteoclasts. Paeoniae Radix Alba has been used in korean traditional medicine to treat disease including inflammation, gynecopathy and various pain. However, these effects have not been tested on osteoclasts, the bone resorbing cells that regulate bone metabolism. Here, we investigated the effects of Paeoniae Radix Alba ethanol extract (PRAE) on receptor activator of nuclear factor-kappa B ligand (RANKL)-mediated osteoclast differentiation and formation. Osteoclast differentiation and formation were measured by tartrate resistant acidic phosphatase (TRAP) staining and TRAP solution assay. The treatment of PRAE on bone marrow derived macrophages (BMMs), which is known as osteoclast precursor cells, inhibited osteoclast differentiation and formation in a dose-dependent manner. In addition, the expression of osteoclast differentiation marker genes was suppressed by PRAE treatment. This inhibitory effect of PRAE resulted from significant repression of c-Fos expression, and subsequent reduction of NFATc1 expression which was previously reported as a master transcription factor for osteoclastogenesis in vitro and in vivo. These results demonstrate that PRAE negatively regulates osteoclast differentiation and formation and suggest that PRAE can be used as a potent preventive or therapeutic candidate for various bone diseases, such as postmenopausal osteoporosis, periodontitis and rheumatoid arthritis.
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참고문헌 (25건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | Osteoimmunology: interplay between the immune system and bone metabolism.  |
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| 2 | Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. |
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| 3 | Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts |
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| 4 | Osteoclast differentiation and activation |
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| 5 | Genetic regulation of osteoclast development and function |
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| 6 | Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts |
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| 7 | Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. |
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| 8 | The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells. |
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| 9 | Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. |
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| 10 | Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. |
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| 11 | NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). |
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| 12 | Kim, T.J., Shin, J.Y. Korean oriental medicine keeping with our herbal(3). 1st ed. Seoul:Liyou. pp 154-157, 2003. | 미소장 |
| 13 | Kim, J. Enhancing Effect of Paeonia japonica, Houttuynia cordata, and Aster scaber Extracts on the Immunoreactivity in vivo in mice. Graduate School of Sookmyung Women’s University. Ph.D Thesis, 2003. | 미소장 |
| 14 | Chemical studies on the oriental plant drugs—XXIII |
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| 15 | [Pharmacological studies on herb paeony root. I. Central effects of paeoniflorin and combined effects with licorice component Fm 100]. |
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| 16 | Inhibition of Tumor Growth through Macrophage Activation by Polysaccharide Fraction from Peonia japonica (PJ - P) | 소장 |
| 17 | Effect of Extracts from Paeonia japonica on the Growth of Food-borne Pathogens | 소장 |
| 18 | Lee, G.H., Kang, S.S., An, W.G., Lee, Y.S., Kwon, Y.K., Shin, S.W. Comparison of Immune Promotion Effects of Water-extracted Angelicae gigantis, Rehmanniae Radix, Paeoniae japonica and Polygoni multiflori Radix. Korean J. Oriental Physiology & Pathology. 20(6):1507-1515, 2006. | 미소장 |
| 19 | Oh, H., Park, H.R., Jeong, I.Y., Kim, S.H., Jo, S.K. Protective Effects of Paeonia japonica against Radiation-induced Damage. J Korea Asso Radial Prot. 27(3):181-188, 2002. | 미소장 |
| 20 | Lee, J.C., Park, S.Y., Choi, J.H., Kim, J.H. Effects of Paeoniae radix alba(PRA) on Skin whitening and Elasticity unsing Melanoma cells. J Korean Med Ophthalmol Otolaryngol Dermatol. 25(1):1-11, 2012. | 미소장 |
| 21 | Yoonm H,J,, Go, E.B., Choi, M.S., Kim, D.I., Sung, J.S. Antioxidant Effect of Paeonia Japonica Extracts on Mouse Embryonic Fibroblast Cells. J Korean Obstet Gynecol. 25(2):78-88, 2012. | 미소장 |
| 22 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. |
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| 23 | Park, S.M., Yoo, D.Y. Effects of Samkieumgamibang Extract on Osteoclast Differentiation and Osteoblast Function. J Korean Obstet Gynecol. 25(2):23-42, 2012. | 미소장 |
| 24 | Effects of Jakyakkamchobuja-tang (芍藥甘草附子湯) on Papain-induced Osteoarthritis in Mice | 소장 |
| 25 | Anti-inflammatory effect of Sanshuibaihu decoction may be associated with nuclear factor-κB and p38 MAPKα in collagen-induced arthritis in rat |
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