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Background: The objective of this study was to investigate the time-course of the expression of TNF-α, IL-6, and IL-1βafter L5 spinal nerve transection (SNT), and to determine the effect of small interfering RNA (siRNA) targeting these cytokines on neuropathic pain.

Methods: Rats received control siRNA (CON group, n = 80) or a cocktail of siRNAs targeting these cytokines (COCK group,n = 70). The siRNAs were given via intrathecal catheter 1 d prior to SNT, on the operation day, and 1, 2 and 3 d postoperatively. Behavioral tests and levels of the cytokine mRNAs and proteins as well as glial cell activity were following the L5 SNT.

Results: In the CON group, TNF-α and IL-1β mRNA levels increased immediately after SNT and remained high for 6 d, while IL-6 transcripts only began to increase after 12 h. TNF-α and IL-1β mRNA levels in the COCK group were lower than in the CON group at all time points (P <0.05). In the behavioral tests, allodynia and hyperalgesia were significantly lower in the COCK group from 2 d after SNT (P < 0.05).

Conclusions: The time courses of TNF-α, IL-6 and IL-1β mRNA expression after L5 SNT differ. RNA interference may be a method of reducing the development of mechanical allodynia and hyperalgesia in response to nerve injury.

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기사명 저자명 페이지 원문 목차
Expression of the spinal 5-HT7 receptor and p-ERK pathway in the carrageenan inflammatory pain of rats 조수영, 기형곤, Joung Min Kim, 오진명, 양지훈, 김웅모, Hyung Gon Lee, Myung Ha Yoon, 최정일 pp.170-174
The values shown on optical technology-based patient monitors must be cautiously interpreted: intravenous dye-induced errors 박희평 pp.97-98
The first step to good clinical research: statistical thinking 이상석 pp.99-100
Malposition of central venous catheter in the jugular venous arch via external jugular vein : a case report 안소운, 이주호, 박정현, 홍용우, 전덕희 pp.175-178
Comparison of the rate of successful endotracheal intubation between the "sniffing" and "ramped" positions in patients with an expected difficult intubation : a prospective randomized study 이주환, 정회창, 심지훈, 이철 pp.116-121
Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration 고영권, 김윤희, 박상일, 정우석, 노찬, 이정은 pp.136-140
The predictive performance of infusion strategy nomogram based on a fluid kinetic model 최병문, 감명환, 정겨운, 여영구, 최규택 pp.128-135
Statistical and methodological considerations for reporting RCTs in medical literature 이상석, 강현 pp.106-115
Epidural anesthesia for pilonidal sinus surgery : ropivacaine versus levobupivacaine Zeynep Nur Orhon, Emine Nursen Koltka, Sibel Devrim, Sevil Tüfekçi, Serkan Doğru, Melek Çelik pp.141-147
The optimal anesthetic depth for interventional neuroradiology: comparisons between light anesthesia and deep anesthesia 정유선, 한예름, 최은수, 김병건, 박희평, Jung-Won Hwang, 전영태 pp.148-152
Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after laparoscopic gynecological surgery 박중호, 이치우, 신영민, 안지현, 반종석, 이지향 pp.153-158
The time-course and RNA interference of TNF-α, IL-6, and IL-1β expression on neuropathic pain induced by L5 spinal nerve transection in rats 최병문, 이수한, 안상미, 박도양, 이관우, 노규정 pp.159-169
Epidural anesthesia for permanent spinal cord stimulation with a cylindrical type lead : a case series 이상은, 최락민, 기림, 이강훈, 전상윤, 정재욱, Woo-Jin Kim, Jin Sun Yoon pp.179-183
Hydrothorax with alveolar-pleural fistula mimicking re-expansion pulmonary edema during liver transplantation : a case report 우재희, 정락경, 백희정, 김윤진 pp.184-187
Acute gastric dilatation causing fatal outcome in a young female with eating disorder : a case report 염승목, 김지영, 이정림 pp.188-192
Complete resolution of myoclonus-like involuntary movements under subarachnoid block after midazolam administration in a patient undergoing cesarean section : a case report Takahiro Nakamoto, Kiichi Hirota, Teppei Iwai, Koh Shingu pp.193-195
Anesthesia awareness. Can midazolam attenuate or prevent memory consolidation on intraoperative awakening during general anesthesia without increasing the risk of postoperative delirium? Marco Cascella pp.200-202
A sheared Racz catheter in cervical epidural space for thirty months: a case report 강재혁, 최훈, 김진성, 이민규, 박휴정 pp.196-199
Transfusion-related acute lung injury : clinical perspectives 김정민, 나성원 pp.101-105
Effects of intravenously administered indocyanine green on near-infrared cerebral oximetry and pulse oximetry readings 백호영, 이현정, 김정민, 조수영, 정성태, 유경연 pp.122-127

참고문헌 (28건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Translation of symptoms and signs into mechanisms in neuropathic pain. 네이버 미소장
2 Importance of glial activation in neuropathic pain 네이버 미소장
3 Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. 네이버 미소장
4 Effect of interleukin-1β on the release of substance P from rat isolated spinal cord 네이버 미소장
5 Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. 네이버 미소장
6 Cutaneous hyperalgesia induced by peripheral injection of interleukin-1β in the rat 네이버 미소장
7 Short interfering RNA (siRNA): tool or therapeutic? 네이버 미소장
8 siRNA relieves chronic neuropathic pain 네이버 미소장
9 Lumbar catheterization of the spinal subarachnoid space in the rat 네이버 미소장
10 Segmental spinal nerve ligation model of neuropathic pain. 네이버 미소장
11 An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons 네이버 미소장
12 The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior 네이버 미소장
13 Sweitzer S, Martin D, DeLeo JA. 2001. Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience, 103, 529-39. 미소장
14 TNF-alpha and neuropathic pain--a review. 네이버 미소장
15 Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain 네이버 미소장
16 Cytokines and the nervous system II: actions and mechanisms of action 네이버 미소장
17 Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia 네이버 미소장
18 Sommer C, Schmidt C, George A. 1998. Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1. Exp Neurol, 151, 138-42. 미소장
19 Poole S, Cunha FQ, SH F. Hyperalgesia from subcutanesou cytokines. In: Cytokines and Pain. Edited by Watkins LR, Maier SF. Birkhauser, Basel. 1999, pp 59-87. 미소장
20 Discordant protein and mRNA expression in lung adenocarcinomas. 네이버 미소장
21 The Effects of Local Pentoxifylline and Propentofylline Treatment on Formalin-Induced Pain and Tumor Necrosis Factor-α Messenger RNA Levels in the Inflamed Tissue of the Rat Paw 네이버 미소장
22 Gene Silencing by Systemic Delivery of Synthetic siRNAs in Adult Mice 네이버 미소장
23 The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. 네이버 미소장
24 Knocking down barriers: advances in siRNA delivery 네이버 미소장
25 Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. 네이버 미소장
26 Birmingham A, Anderson EM, Reynolds A, Ilsley-Tyree D, Leake D, Fedorov Y. 2006. 3’ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Methods, 3, 199-204. 미소장
27 Specificity of Short Interfering RNA Determined through Gene Expression Signatures 네이버 미소장
28 Activation of the interferon system by short-interfering RNAs 네이버 미소장

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