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β-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and its mechanism of action have remained elusive. The purpose of this study was to examine whether BAS improved spatial cognitive impairment induced in rats following chronic corticosterone (CORT) administration. CORT administration (40 mg/kg, i.p., 21 days) resulted in cognitive impairment in the avoidance conditioning test (AAT) and the Morris water maze (MWM) test that was reversed by BAS (200 mg/kg, i.p). Additionally, as assessed by immunohistochemistry and RT-PCR analysis, the administration of BAS significantly alleviated memory-associated decreases in the expression levels of brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding protein (CREB) proteins and mRNAs in the hippocampus. Also, BAS administration significantly restored the expression of Bax and Bcl-2 mRNAs in the hippocampus. Thus, BAS may be an effective therapeutic for learning and memory disturbances, and its neuroprotective effect was mediated, in part, by normalizing the CORT response, resulting in regulation of BDNF and CREB functions and anti-apoptosis in rats.

Key Words: β-asaron

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번호 참고문헌 국회도서관 소장유무
1 A randomized controlled trial of prednisone in Alzheimer's disease. 네이버 미소장
2 Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease 네이버 미소장
3 BDNF is essential to promote persistence of long-term memory storage. 네이버 미소장
4 Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats 네이버 미소장
5 β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice 네이버 미소장
6 Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus 네이버 미소장
7 Cory, S and Adams, J. M. (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656. 미소장
8 Csernansky, J. G., Dong, H., Fagan, A. M., Wang, L., Xiong, C., Holtzman, D. M. and Morris, J. C. (2006) Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia. Am. J. Psychiatry 163, 2164-2169. 미소장
9 Neuropsychopharmacology: the 2013 transition in leadership. 네이버 미소장
10 Efimova, O. I., Ierusalimskii, V. N., Anokhin, K. V. and Balaban, P. M. (2007) Immunohistochemical detection of the activation of CREB and c-Fos transcription factors in the nervous system of the terrestrial snail induced by pentylenetetrazole. Neurosci. Behav. Physiol. 37, 853-856. 미소장
11 Endo, Y., Nishimura, J. I., Kobayashi, S. and Kimura, F. (1999) Chronic stress exposure influences local cerebral blood flow in the rat hippocampus. Neuroscience 93, 551-555. 미소장
12 Beta-Asarone Improves Cognitive Function by Suppressing Neuronal Apoptosis in the Beta-Amyloid Hippocampus Injection Rats 네이버 미소장
13 Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia 네이버 미소장
14 [Leu]enkephalin enhances active avoidance conditioning in rats and mice. 네이버 미소장
15 Meta-analysis of sex differences in rodent models of learning and memory: a review of behavioral and biological data. 네이버 미소장
16 Kim, B. K., Ko, I. G., Kim, S. E., Kim, C. J., Yoon, J. S., Baik, H. H., Jin, B. K., Lee, C. Y., Baek, S. B. and Shin, M. S. (2013) Impact of several types of stresses on short-term memory and apoptosis in the hippocampus of rats. Int. Neuroural. J. 17, 114-120. 미소장
17 Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus 네이버 미소장
18 Regional differences in acute corticosterone-induced dendritic remodeling in the rat brain and their behavioral consequences. 네이버 미소장
19 Footshock stress alters early postnatal development of electrophysiological responses and caspase-3 activity in rat hippocampus 네이버 미소장
20 Increased generation of granule cells in adult Bcl‐2‐overexpressing mice: a role for cell death during continued hippocampal neurogenesis 네이버 미소장
21 Antifungal activity of beta-asarone from rhizomes of Acorus gramineus. 네이버 미소장
22 Acupuncture stimulation alleviates corticosterone-induced impairments of spatial memory and cholinergic neurons in rats. 네이버 미소장
23 Baicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the rat 네이버 미소장
24 Anti-amnesic effect of Chong–Myung–Tang on scopolamine-induced memory impairments in mice 네이버 미소장
25 Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins 네이버 미소장
26 Li, Z., Zhao, G., Qian, S., Yang, Z., Chen, X., Chen, J., Cai, C., Liang, X. and Guo, J. (2012) Cerebrovascular protection of β-asarone in Alzheimer's disease rats: a behavioral, cerebral blood flow, biochemical and genic study. J. Ethnopharmacol. 144, 305-312. 미소장
27 Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-beta((25-35)). 네이버 미소장
28 Beta-Asarone Attenuates Neuronal Apoptosis Induced by Beta Amyloid in Rat Hippocampus 네이버 미소장
29 Chronic psychosocial stress differentially affects apoptosis in hippocampal subregions and cortex of the adult tree shrew 네이버 미소장
30 Age-related impairments in memory and in CREB and pCREB expression in hippocampus and amygdala following inhibitory avoidance training 네이버 미소장
31 Nacher, J., Pham, K., Gil-Fernandez, V. and McEwen, B. S. (2004) Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex. Neuroscience 126, 503-509. 미소장
32 Paxinos, G. and Watson, C. (1986) The rat brain in stereotaxic coordinates. 3, 54-85. Academic Press. New York, USA. 미소장
33 Chronic corticosterone-induced deterioration in rat behaviour is not paralleled by changes in hippocampal NF-kappaB-activation. 네이버 미소장
34 Rashidy-Pour, A., Vafaei, A. A., Taherian, A. A., Miladi-Gorji, H., Sadeghi, H., Fathollahi, Y. and Bandegi, A. R. (2009) Verapamil enhances acute stress or glucocorticoid-induced deficits in retrieval of long-term memory in rats. Behav. Brain Res. 203, 76-80. 미소장
35 Controversies surrounding glucocorticoid-mediated cell death in the hippocampus 네이버 미소장
36 Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala. 네이버 미소장
37 Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions 네이버 미소장
38 Sajadi, A. A., Samaei, S. A. and Rashidy-Pour, A (2007) Blocking effects of intra-hippocampal naltrexone microinjections on glucocorticoid-induced impairment of spatial memory retrieval in rats. Neuropharmacology 52, 347-354. 미소장
39 Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion 네이버 미소장
40 CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice. 네이버 미소장
41 The role of CREB signaling in Alzheimer's disease and other cognitive disorders 네이버 미소장
42 Simulated weightlessness aggravates hypergravity-induced impairment of learning and memory and neuronal apoptosis in rats 네이버 미소장
43 Vaynman, S., Ying, Z. and Gomez-Pinilla, F. (2008) Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience, 122, 647-657. 미소장
44 Gingkoselect alleviates chronic corticosterone-induced spatial memory deficits in rats 네이버 미소장
45 Ginkgo biloba normalizes stress- and corticosterone-induced impairment of recall in rats. 네이버 미소장
46 The effect of Acorus gramineus on the bioavailabilities and brain concentrations of ginsenosides Rg1, Re and Rb1 after oral administration of Kai-Xin-San preparations in rats 네이버 미소장
47 Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels 네이버 미소장
48 A subchronic application period of glucocorticoids leads to rat cognitive dysfunction whereas physostigmine induces a mild neuroprotection. 네이버 미소장
49 Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress 네이버 미소장
50 Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells. 네이버 미소장

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