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Purpose: The revised Berlin definition (BD) showed better predictive validity for mortality in adults with acute respiratory distress syndrome (ARDS). We examined the validity of BD for pediatric ARDS as compared to the American–European Consensus Conference definition (AECCD).
Methods: This single–center, retrospective study included 127 patients aged 1 month to 19 years who were admitted to the medical intensive care unit due to acute lung injury (ALI, n=31) or ARDS (n=96) using the AECCD. All patient characteristics and mortality rates were compared between the individual severity groups according to the BD and AECCD.
Results: Sixty–four patients (50%) died. Mortality rates increased across the severity groups according to both definitions (26% in mild, 42% in moderate, and 75% in severe by the BD [P<0.001]; 26% in ALI non–ARDS and 58% in ARDS by the AECCD [P=0.002]). The mortality risk increased only for ‘severe ARDS’ (hazard radio for mortality, 2.56; 95% confidence intervals [CI], 1.14–5.78; P=0.023) after adjusting for confounding factors. The BD better predicted mortality, with an integrated area under the receiver operating characteristic curve (iAUC) of 0.651 (95% CI, 0.571–0.725), than the AECCD, with an iAUC of 0.584 (95% CI, 0.523–0.637). The pediatric risk of mortality (PRISM) III and pediatric index of mortality 3 scores were significantly different across BD severity groups, whereas only PRISM III scores were different according to the AECCD.
Conclusion: The BD applied to children with ARDS. It could be adopted to severity classifications and predict pediatric ARDS mortality better than the AECCD.| 번호 | 참고문헌 | 국회도서관 소장유무 |
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| 1 | ACUTE RESPIRATORY DISTRESS IN ADULTS ![]() |
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| 2 | Intravascular coagulation associated with the adult respiratory distress syndrome ![]() |
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| 3 | Clinical predictors of the adult respiratory distress syndrome ![]() |
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| 4 | Adult respiratory distress syndrome: risk with common predispositions. ![]() |
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| 5 | An expanded definition of the adult respiratory distress syndrome. ![]() |
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| 6 | Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149(3 Pt 1):818-24. | 미소장 |
| 7 | Current definitions of acute lung injury and the acute respiratory distress syndrome do not reflect their true severity and outcome. ![]() |
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| 8 | An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. ![]() |
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| 9 | Acute respiratory distress syndrome: the Berlin Definition. ![]() |
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| 10 | New Definition of Acute Respiratory Distress Syndrome | 소장 |
| 11 | Pediatric acute respiratory distress syndrome. ![]() |
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| 12 | Epidemiology and outcome of acute lung injury in European intensive care units ![]() |
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| 13 | Survival predictors in acute respiratory distress syndrome with extracorporeal membrane oxygenation. ![]() |
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| 14 | Assessment of preoperative magnetic resonance imaging staging in patients with hepatocellular carcinoma undergoing resection compared with the seventh American Joint Committee on Cancer System. ![]() |
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| 15 | Definition of Acute Respiratory Distress Syndrome ![]() |
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| 16 | Phillips CR. The Berlin definition: real change or the emperor's new clothes? Crit Care 2013;17:174. | 미소장 |
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| 18 | Temporal evolution of acute respiratory distress syndrome definitions ![]() |
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| 19 | Management of acute lung injury and acute respiratory distress syndrome in children ![]() |
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| 20 | Pediatric Acute Lung Injury Epidemiology and Natural History study: Incidence and outcome of the acute respiratory distress syndrome in children. ![]() |
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| 21 | Multidrug-resistant bacteria in hospitalized children: a 5-year multicenter study. ![]() |
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| 22 | Acute Respiratory Distress Syndrome ![]() |
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| 24 | Epidemiology of pediatric acute respiratory distress syndrome in singapore: risk factors and predictive respiratory indices for mortality. ![]() |
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| 26 | Mortality Rates for Patients With Acute Lung Injury/ARDS Have Decreased Over Time ![]() |
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| 27 | Pediatric Acute Respiratory Distress Syndrome: Consensus Recommendations From the Pediatric Acute Lung Injury Consensus Conference* ![]() |
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| 28 | Incidence and outcomes of pediatric acute lung injury. ![]() |
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| 29 | Incidence of acute respiratory distress syndrome in German children and adolescents: a population-based study. ![]() |
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| 30 | De Luca D, Piastra M, Chidini G, Tissieres P, Calderini E, Essouri S, et al. The use of the Berlin definition for acute respiratory distress syndrome during infancy and early childhood: multicenter evaluation and expert consensus. Intensive Care Med 2013;39:2083-91. | 미소장 |
| 31 | Gemke RJ, van Vught J. Scoring systems in pediatric intensive care: PRISM III versus PIM. Intensive Care Med 2002;28:204-7. | 미소장 |
| 32 | Visser IH, Hazelzet JA, Albers MJ, Verlaat CW, Hogenbirk K, van Woensel JB, et al. Mortality prediction models for pediatric intensive care: comparison of overall and subgroup specific performance. Intensive Care Med 2013;39:942-50. | 미소장 |
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