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Contents

Protective effect of ginsenoside Rh3 against anticancer drug-induced apoptosis in LLC-PK1 kidney cells / Hye Lim Lee ; Ki Sung Kang 101

ABSTRACT 101

1. Introduction 101

2. Materials and methods 102

2.1. Chemicals 102

2.2. Cell culture and [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) cell viability assay 102

2.3. Western blotting analysis 103

2.4. Image-based cytometric assay 103

3. Results and discussion 103

References 105

초록보기

Background: Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity of ginsenosides can be enhanced by modulating their stereospecificity by heat processing. Ginsenosides Rk2 and Rh3 represent positional isomers of the double bond at C-20(21) or C-20(22).

Methods: The present study investigated the kidney-protective effects of ginsenosides Rk2 and Rh3 against cisplatin, a platinum based anticancer drug, induced apoptotic damage in renal proximal LLC-PK1 cells.

Results: As a result, ginsenoside Rh3 shows a stronger protective effect than that shown by Rk2.

Cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), p38, and cleaved caspase-3 decreased after cotreatment with ginsenoside Rh3. The increase in the percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment also significantly reduced after cotreatment with ginsenoside Rh3.

Conclusion: These results demonstrate that inhibition of the JNK and ERK mitogen-activated protein kinase signaling cascade plays a critical role in mediating the renoprotective effect of ginsenoside Rh3.

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Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2 Tao Yu, Yanyan Yang, Yi-Seong Kwak, Gwan Gyu Song, Mi-Yeon Kim, Man Hee Rhee, Jae Youl Cho pp.127-133

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Genetic defects in the nef gene are associated with Korean Red Ginseng intake : monitoring of nef sequence polymorphisms over 20 years Young-Keol Cho, Jung-Eun Kim, Jun-Hee Woo pp.144-150

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Preventive effect of fermented black ginseng against cisplatin-induced nephrotoxicity in rats Kiwon Jung, Jun Min An, Dae-Woon Eom, Ki Sung Kang, Su-Nam Kim pp.188-194

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The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet Min Hee Kim, Jongsung Lee, Sehyun Jung, Joo Wan Kim, Jae-Ho Shin, Hae-Jeung Lee pp.120-126

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Ginseng authenticity testing by measuring carbon, nitrogen, and sulfur stable isotope compositions that differ based on cultivation land and organic fertilizer type Ill-Min Chung, Taek-Jun Lee, Yong-Taek Oh, Bimal Kumar Ghimire, In-Bae Jang, Seung-Hyun Kim pp.195-200

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Protective effect of ginsenoside Rh3 against anticancer drug-induced apoptosis in LLC-PK1 kidney cells Hye Lim Lee, Ki Sung Kang pp.227-231

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Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration Yin Bin Chen, Yu Fang Wang, Wei Hou, Ying Ping Wang, Sheng Yuan Xiao, Yang Yang Fu, Jia Wang, Si Wen Zheng, Pei He Zheng pp.209-214

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Effects of ginseng on two main sex steroid hormone receptors : estrogen and androgen receptors Joonwoo Park, Heewon Song, Si-Kwan Kim, Myeong Soo Lee, Dong-Kwon Rhee, YoungJoo Lee pp.215-221

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Implications of red Panax ginseng in oxidative stress associated chronic diseases Yoon-Mi Lee, Haelim Yoon, Hyun-Min Park, Byeng Chun Song, Kyung-Jin Yeum pp.113-119

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Black ginseng-enriched Chong-Myung-Tang extracts improve spatial learning behavior in rats and elicit anti-inflammatory effects in vitro Evelyn Saba, Da-Hye Jeong, Seong-Soo Roh, Seung-Hyung Kim, Sung-Dae Kim, Hyun-Kyoung Kim, Man-Hee Rhee pp.151-158

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The psychopharmacological activities of Vietnamese ginseng in mice: characterization of its psychomotor, sedativeehypnotic, antistress, anxiolytic, and cognitive effects Irene Joy I. dela Peña, Hee Jin Kim, Chrislean Jun Botanas, June Bryan de la Peña, Thi Hong Van Le, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon Cheong pp.201-208

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The beneficial effect of ginsenosides extracted by pulsed electric field against hydrogen peroxide-induced oxidative stress in HEK-293 cells Di Liu, Ting Zhang, Zhifei Chen, Ying Wang, Shuang Ma, Jiyun Liu, Jingbo Liu pp.169-179

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