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Background and Purpose To determine the risk of Parkinson’s disease (PD) in relation to erectile dysfunction (ED) based on the National Health Insurance Research Database in Taiwan.

Methods We identified 3,153 patients who were newly diagnosed with ED between January 1, 2004 and December 31, 2010. A total of 12,612 randomly selected people without ED served as healthy controls. All of the study subjects were followed-up from the index date to the date of PD diagnosis, withdrawal from the National Health Insurance program, or the end of 2012 whichever occurred first.

Results The incidence density rate of PD was 1.52-fold higher in the ED cohort than the non-ED cohort (3.44 vs. 1.64 per 1,000 person-years), with an adjusted hazard ratio (HR) of 1.52 [95% confidence interval (CI)=1.09–2.12]. The combined effects on patients with ED and diabetes as well as hypertension showed a significant combined association with the PD risk compared with patients without ED, counterpart comorbidities, or medication use. The adjusted HR of PD for ED was higher for diabetes (2.82, 95% CI=1.42–5.63) and hypertension (2.19, 95% CI = 1.35–3.55).

Conclusions ED leads to an increased risk of PD. ED patients with diabetes or hypertension have an elevated risk of PD.

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참고문헌 (39건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Erectile dysfunction 네이버 미소장
2 Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999;84:50-56. 미소장
3 McKinlay JB. The worldwide prevalence and epidemiology of erectile dysfunction. Int J Impot Res 2000;12 Suppl 4:S6-S11. 미소장
4 Prediction of cardiovascular events and all-cause mortality with erectile dysfunction: a systematic review and meta-analysis of cohort studies. 네이버 미소장
5 Erectile Dysfunction and Men's Health: Developing a Comorbidity Risk Calculator 네이버 미소장
6 Erectile Function and Risk of Parkinson's Disease 네이버 미소장
7 Genitourinary dysfunction in Parkinson's disease 네이버 미소장
8 A case-control study of dietary salt intake and risk of pediatric multiple sclerosis (MS) (S38.003) 네이버 미소장
9 臺灣全民健康保險資料庫糖尿病診斷的正確性 네이버 미소장
10 Geographic variation in the age- and gender-specific prevalence and incidence of epilepsy: analysis of Taiwanese National Health Insurance-based data. 네이버 미소장
11 Validation of the national health insurance research database with ischemic stroke cases in Taiwan 네이버 미소장
12 Use of 5-alpha-reductase inhibitors did not increase the risk of cardiovascular diseases in patients with benign prostate hyperplasia: a five-year follow-up study. 네이버 미소장
13 Zolpidem and the risk of Parkinson's disease: A nationwide population-based study 네이버 미소장
14 Chiang TL. Taiwan’s 1995 health care reform. Health Policy 1997;39:225-239. 미소장
15 Mortality and causes of death in a national sample of diabetic patients in Taiwan. 네이버 미소장
16 Lichen Simplex Chronicus Associated With Erectile Dysfunction: A Population-Based Retrospective Cohort Study. 네이버 미소장
17 Statin reduces mortality and morbidity in systemic lupus erythematosus patients with hyperlipidemia: A nationwide population-based cohort study 네이버 미소장
18 Validation of a combined comorbidity index 네이버 미소장
19 Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-383. 미소장
20 The association between zolpidem and infection in patients with sleep disturbance 네이버 미소장
21 Risk of premotor symptoms in patients with newly diagnosed PD: a nationwide, population-based, case-control study in Taiwan. 네이버 미소장
22 Maximum Urine Flow Rate of Less than 15ml/Sec Increasing Risk of Urine Retention and Prostate Surgery among Patients with Alpha-1 Blockers: A 10-Year Follow Up Study. 네이버 미소장
23 Reply to the Letter by Andrade 네이버 미소장
24 Parkinson’s disease and risk of hip fracture: An 8-year follow-up study in Taiwan 네이버 미소장
25 Acute Urinary Retention Increases the Risk of Complications After Transurethral Resection of The Prostate: A Population‐Based Study 네이버 미소장
26 Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort 네이버 미소장
27 Meta‐analysis of early nonmotor features and risk factors for Parkinson disease 네이버 미소장
28 Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications. 네이버 미소장
29 Migraine and erectile dysfunction: evidence from a population-based case-control study. 네이버 미소장
30 Smaldone M, Sukkarieh T, Reda A, Khan A. Epilepsy and erectile dysfunction: a review. Seizure 2004;13:453-459. 미소장
31 Jannini EA, McCabe MP, Salonia A, Montorsi F, Sachs BD. Organic vs. psychogenic? The Manichean diagnosis in sexual medicine. J Sex Med 2010;7:1726-1733. 미소장
32 Chen YC, Yeh HY, Wu JC, Haschler I, Chen TJ, Wetter T. Taiwan’s National Health Insurance Research Database: administrative health care database as study object in bibliometrics. Scientometr 2011;86:365-380. 미소장
33 Dysautonomia in Parkinson's disease: neurocardiological abnormalities 네이버 미소장
34 Staging of brain pathology related to sporadic Parkinson`s disease 네이버 미소장
35 Mikhail N. Does testosterone have a role in erectile function? Am J Med 2006;119:373-382. 미소장
36 Refractory nonmotor symptoms in male patients with Parkinson disease due to testosterone deficiency: a common unrecognized comorbidity. 네이버 미소장
37 Beneficial effects of testosterone replacement for the nonmotor symptoms of Parkinson disease. 네이버 미소장
38 Testosterone improves motor function in Parkinson's disease. 네이버 미소장
39 Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion 네이버 미소장

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