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This study was conducted to investigate of hepatoprotective effect of dandelion water extract (DWE) according to repeated administration of thioacetamide (TAA) induced hepatotoxicity in Spraque-Dawley rats. Thirty rats were randomly assigned to 5 groups; normal control, DWE-control, TAA-control (TAA injection during the feeding of normal diet), TAA&DWE600 (TAA repeated injection during the feeding of DWE 600 mg/kg BW), TAA&DWE1200 (TAA repeated injection during the feeding of DWE 1,200 mg/kg BW). Rats in DWE-control and TAA&DWE groups were treated with DWE (600 or 1,200 mg/kg BW daily) by gavage for 20 days (twice a day). All the rats in the TAA-control and TAA&DWE groups were repeated injection of TAA (100 mg/kg BW) into the abdominal cavity 3 days interval and 12 hrs later, all rats were sacrificed. At the same time, normal control and DWE-control groups were injected normal saline. In TAA&DWE groups, serum alanine and aspartate aminotransferase (ALT, AST) were significantly decreased and triglyceride (TG) synthesis was significantly increased compared to TAA group. As well as total billilubin and GGT were slightly decreased by the treatment of DWE. Lipid peroxidation (MDA) concentration was significantly decreased and hepatic GSH content was slightly or significantly increased in the TAA&DWE groups compared to TAA group. Hepatic anti-oxidative enzyme activities, such as GSH, GST, SOD and catalase were slightly or significantly elevated by the treatment of DWE. According to these results, When dandelion extract was long term supplied, it could be used as a potential protective material for a longer time liver damage by repeated adminstra-tion of the TAA.

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기사명 저자명 페이지 원문 목차
Phenobarbital and zonisamide treatment of a cat with epilepsy of unknown cause Ki-Ho Lee, Jun-Seok Park, Jung-Kook Kim, Kyoung-Won Seo, Kun-Ho Song pp.143-147

천연기념물 한국 산양의 혈액 및 혈액 화학적 정상표준범위 = Hematologic and biochemical reference intervals for natural monument Korean goral (Naemorhedus caudatus) 안상진, 최영진, 김종택 pp.155-159

돼지에서 분리한 Salmonella Typhimurium의 항생제 내성 양상 = Characteristics of antimicrobial resistant Salmonella Typhimurium isolates from pigs 손준형, 김미숙, 이영미, 도재철 pp.83-87

랫드에서 thioacetamide의 반복 투여로 유도된 간 손상에 대한 민들레 추출물의 효과 = Protective effects of dandelion extract against liver damage by repeated administration of thioacetamide in rats 문선진, 신성식, 손창호, 오기석, 김하정, 정지영, 서국현 pp.107-117

경남 북부지역 오리 분변에서 분리된 Campylobacter spp.의 항생제 내성 = Antimicrobial resistance of Campylobater spp. from duck feces in northern area of the Gyeongnam province, Korea 김형수, 서덕진, 성민호, 한권식, 박정용, 정명호, 박동엽, 박동주, 고필옥 pp.101-105

인천지역 산란계 가금질병 항체 보유율 조사 = Prevalence of antibody titers for poultry disease in laying hens in Incheon area, Korea 김일연, 이정애, 정철, 윤일채, 송재성, 정윤정, 이윤미, 임지흔, 이정구, 이성모 pp.89-94

High prevalence of avian hematozoan parasite infection in wild owls in Chungbuk province of Korea (mid-South Korea) Hye-Jin Jang, Ki-Jeong Na, Haerin Rhim, Jae-Ik Han pp.95-99

Utilization of multivalent vaccine on sows ante partum for the prevention of piglet enteritis Yeonsu Oh, Myung-Hyee Kim, Jeong-Hee Han pp.133-137

사료자원에 서식하는 세균의 소화효소활성, 항생제내성 및 병원성에 관한 특성 = Characteristics of digestive enzyme activity, antibiotic resistance, and pathogenicity of bacteria inhabited in animal feed resources 이권정, 조상섭, 김수기 pp.119-131

Primary pulmonary adenocarcinoma metastasized to kidney in a captive nutria (Myocastor coypus) Yeonsu Oh, Ho-Seong Cho pp.139-142

국내 중간기착지에서 철새의 조류 폭스 감염 조사 = The survey on avian pox infections in migratory birds at a stopover site, South Korea 김희종, 채희영, 박성준, 성환우, 김종택 pp.149-153

참고문헌 (50건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Acute and Chronic Toxicity of Thioacteamide and Alterations in Blood Cell Indices in Rats 네이버 미소장
2 Reactive Oxygen Species in Health and Disease 네이버 미소장
3 In Vitro Free Radical Scavenging and Hepatoprotective Activities of Taraxacum mongolicum 소장
4 Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress. 네이버 미소장
5 Manifestations of chemically induced liver damage. 네이버 미소장
6 Bisset NG, Phillipson JD, Czygan FC, Frohne D, Höoltzel D, Nagell A, Pfander HJ, Willuhn G, Buff W. 1994. Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis. pp. 486-489. CRC Press, London. 미소장
7 Hepatoprotection of silymarin against thioacetamide‐induced chronic liver fibrosis 네이버 미소장
8 Cho IY, Ma SR, Moon SJ, Yu DH, Shin SS, Son CH, Oh KS, Hur TY, Jung YH, Choi CY, Suh GH. 2003. Hepatoprotective effects of the aqueous extract from Taraxacum officinale (Dandelion) against Thioacetamideinduced hepatotoxicity in rats. Korean J Vet Serv 36: 233-242. 미소장
9 The protective effect of taurine against thioacetamide hepatotoxicity of rats 네이버 미소장
10 Studies of the mechanism of metabolism of thioacetamide s-oxide by rat liver microsomes. 네이버 미소장
11 The biochemical basis of antioxidant therapy in critical illness. 네이버 미소장
12 Diverse biological activities of dandelion 네이버 미소장
13 Guerra RR, Trotta MR, Aloia TPA, Dagli MLZ, Hernandez- Blazquez FJ. 2010. A novel chronic cirrhosis TAA-induced model in rats. Braz J Vet Pathol 3: 9-16. 미소장
14 Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes. 네이버 미소장
15 Antioxidant defence mechanisms: from the beginning to the end (of the beginning). 네이버 미소장
16 Han SH, Hwang JK, Park SN, Lee KH, Ko KI, Kim KS, Kim KS, Kim KH. 2005. Potential effect of solvent fractions of Taraxacum mongolicum H. on protection of gastric mucosa. Korean J Food Sci Technol 37: 84-89. 미소장
17 Antioxidative Activity of Ethanol Extracts from Different Parts of Taraxacum officinale 소장
18 Antioxidative Activities of Water Extracts from Different Parts of Taraxacum officinale 소장
19 Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum. 네이버 미소장
20 Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. 네이버 미소장
21 Hunter AL, Holscher MA, Neal RA. 1977. Thioacetamide-induced hepatic necrosis I. Involvement of the mixedfunction oxidase enzyme system. J Pharmacol 200: 439-448. 미소장
22 Im DY, Kim SH, Hor JR. 2011. A Comparative Study on Antioxidative Activity of Extracts from Taraxacum coreanum and Taraxacum officinale. Korean Soc Cosmelology 17: 544-549. 미소장
23 Im DY, Lee KI. 2011. A Nitric oxide production inhibitory and scavenging activity and tryosinase inhibitory activity of extracts from Taraxacum officinale and Taraxacum coreanum. Korean J. Medical Crop Sci 19: 362-367. 미소장
24 Kang MJ, Shin SS, Kim LS. 2002. Antioxidative and free radical scavenging activity of water extract from dandelion (Taraxacum officinale). Korean J Food Preserv 9: 253-259. 미소장
25 Katrin S, Reinhold C, Andreas S. 2006. Taraxacum-A review on its phytochemical and pharmacological profile. Journal of Ethnopharmacology 107: 313-323. 미소장
26 Inhibitory effect of fumaric acid on hepatocarcinogenesis by thioacetamide in rats. 네이버 미소장
27 Taraxacum officinale inhibits tumor necrosis factor-alpha production from rat astrocytes. 네이버 미소장
28 Kim JJ, Noh KH, Cho MK, Jang JH, Song YS. 2007. Anti-oxidative, anti-inflammatory and anti-atherogenic effects of dandelion (Taraxacum officinale) extracts in C57BL/6 mice fed atherogenic diet. FASEB J 21: 862-867. 미소장
29 Phenolic Acid Contents and ROS Scavenging Activity of Dandelion(Taraxacum officinale) 소장
30 The Effect of Diphenyl Dimethyl Dicarboxylate on Thioacetamide Treated Acute Hepatic Injury 소장
31 Lee MH, Song SH, Ham IH, Bu YM, Kim HC, Choi HY. 2010. Anti-inflammatory effect and contents from the aerial part and root of the various Taraxacum spp. distributed in Korea. Kor J Herbology 25: 77-84. 미소장
32 Tissue Repair Response as a Function of Dose in Thioacetamide Hepatotoxicity 네이버 미소장
33 Oxidative stress, antioxidants, and assessment of oxidative stress in dogs and cats. 네이버 미소장
34 Antioxidant Activity and Inhibitory Effect of Taraxacum officinale Extracts on Nitric Oxide Production 소장
35 Implication of free radical mechanisms in ethanol-induced cellular injury 네이버 미소장
36 Clinical Applications of Antioxidants 소장
37 Hepatoprotective Activity of Dandelion (Taraxacum officinale) Water Extract against D-Galactosamine-Induced Hepatitis in Rats 소장
38 Porter WR, Gudzinowcz MJ, Neal RA. 1979. Thioacetamide-induced hepatic necrosis. II. Pharmacokinetics of thioacetamide and thioacetamide S-oxide in the rat. J Pharmacol Exp Ther 208: 386-391. 미소장
39 Porter WR, Neal RA. 1978. Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. Drug Metabolism and Disposition 6: 379-388. 미소장
40 Roušar T, Kučera O, Křivraáková P, Lotková H, Kanďár R, Mužaková V, Červinková Z. 2009. Evaluation of oxidative status in acetaminophen treated rat hepatocytes in culture. Physiol Research 58: 239-246. 미소장
41 Schütz K, Carle R, Schieber A. 2006. Taraxacum—A review on its phytochemical and pharmacological profile. Journal of Ethnopharmacology 107: 313-323. 미소장
42 Seo SW, Koo HN, An HJ, Kwon KB, Lim BC, Seo EA, Ryu DG, Moon G, Kim HY, Kim HM, Hong SH. 2005. Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats. World J Gastroenterology 11: 597-599. 미소장
43 Evaluation 네이버 미소장
44 Anti-carcinogenic Activity of Taraxacum Plant. I 네이버 미소장
45 Anti-carcinogenic Activity of Taraxacum Plant. I 네이버 미소장
46 Biochemical aspects of cellular oxidative stress. 네이버 미소장
47 Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale 네이버 미소장
48 In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress 네이버 미소장
49 Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma 네이버 미소장
50 Studies on lipid and lipoprotein metabolism in rat liver cirrhosis induced by different regimens of thioacetamide administration 네이버 미소장

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