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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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We examined the role of spinally located β-adrenergic receptors in the regulation of the blood glucose level. The intrathecal (i.t.) injections with dobutamine (β₁-adrenergic receptor agonist) or terbutaline (β₂-adrenergic receptor agonist) caused an elevation of the blood glucose level, whereas metoprolol (β₁-adrenergic receptor antagonist) or butoxamine (β₂-adrenergic receptor antagonist) did not. In addition, i.t. pretreatment with pertussis toxin (PTX) attenuated the hyperglycemic effect induced by dobutamine or terbutaline. Moreover, plasma insulin level was increased by dobutamine but not by terbutaline, and PTX reduced dobutamine-induced upregulation of the plasma insulin level. Terbutaline significantly increased plasma corticosterone level, and PTX further enhanced terbutaline-induced corticosterone level. Furthermore, intraperitoneal (i.p.) pretreatment with hexamethonium- (a preganglionic blocker) attenuated dobutamine- and terbutaline-induced hyperglycemic effects. Our results suggest that activation of spinal β₁- and β₂-adrenergic receptors produces hyperglycemic effects in a different manner. Spinally located PTX-sensitive G-proteins appear to be involved in hyperglycemic effect induced by terbutaline. Furthermore, dobutamine- or terbutaline-induced hyperglycemia appears to be mediated through the spinal nerves.

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참고문헌 (35건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intolerance. 네이버 미소장
2 The Bed Nucleus of the Stria Terminalis: A Target Site for Noradrenergic Actions in Opiate Withdrawal 네이버 미소장
3 β-Blockers in Congestive Heart Failure: A Bayesian Meta-Analysis 네이버 미소장
4 Depolarization of rat isolated superior cervical ganglia mediated by beta 2-adrenoceptors. 네이버 미소장
5 Plasma corticosterone concentrations in diabetic (db) mice. 네이버 미소장
6 Enhanced beta-adrenergic receptors in the brain and pancreas during pancreatic regeneration in weanling rats. 네이버 미소장
7 Effect of clonidine on glucose, insulin and glucagon responses to a protein meal in type 2 diabetics. 네이버 미소장
8 Medial preoptic area adrenergic receptors modulate glycemia and insulinemia in freely moving rats 네이버 미소장
9 Reduction of mortality, sudden death and non-fatal reinfarction with beta-adrenergic blockers in survivors of acute myocardial infarction: A new hypothesis regarding the cardioprotective action of beta-adrenergic blockade 네이버 미소장
10 Garcia Hermida O, Fontela T, Ghiglione M, Uttenthal LO. 1991. Effect of pertussis pretreatment on plasma glucose and insulin responses to lithium in rats. Br J Pharmacol. 103:1309–1312. 미소장
11 FLUOROMETRIC DETERMINATION OF CORTICOSTERONE AND CORTISOL IN 0.02-0.05 MILLILITERS OF PLASMA OR SUBMILLIGRAM SAMPLES OF ADRENAL TISSUE. 네이버 미소장
12 Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. 네이버 미소장
13 Role of hypothalamic paraventricular nucleus α- and β-adrenergic receptors in regulation of blood glucose, free fatty acids and corticosterone 네이버 미소장
14 Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice 네이버 미소장
15 Effects of the α₂-adrenergic agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine in healthy volunteers. 네이버 미소장
16 The role of alpha- and beta-adrenoceptor subtypes in mediating the effects of catecholamines on fasting glucose and insulin concentrations in the rat. 네이버 미소장
17 Komatsu M, McDermott AM, Gillison SL, Sharp GW. 1995. Time course of action of pertussis toxin to block the inhibition of stimulated insulin release by norepinephrine. Endocrinology. 136:1857–1863. 미소장
18 Sympathetic mediation of peripheral vasodilation induced by spinal cord stimulation: animal studies of the role of cholinergic and adrenergic receptor subtypes. 네이버 미소장
19 Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y. 2009. Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes. J Biol Chem. 284:32279–32287. 미소장
20 The action of beta-adrenergic blocking and stimulating agents on insulin secretion. Characterization of the type of beta receptor. 네이버 미소장
21 Nicotine Abstinence Syndrome Precipitated by Central But Not Peripheral Hexamethonium 네이버 미소장
22 Psaty BM, Smith NL, Siscovick DS, Koepsell TD, Weiss NS, Heckbert SR, Lemaitre RN, Wagner EH, Furberg CD. 1997. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and metaanalysis. JAMA. 277:739–745. 미소장
23 Adrenergic pharmacology and cognition: Focus on the prefrontal cortex 네이버 미소장
24 Distribution and subtype determination of?-receptors in the spinal cord of the adult rat 네이버 미소장
25 Differences in Adrenergic Recognition by Pancreatic A and B Cells 네이버 미소장
26 Schwartz MW, Strack AM, Dallman MF. 1997. Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes. Regul Pept. 72:105–112. 미소장
27 Hypoglycaemia and acute stress-induced hyperinsulinaemia in mice infected with Bordetella pertussis or treated with pertussis toxin. 네이버 미소장
28 Interleukin 1b (IL 1b) increases pain behavior and the blood glucose level: Possible involvement of sympathetic nervous system 네이버 미소장
29 Central anti-diabetic action of biguanide and thizolidinediones in d-glucose fed and streptozotocin-treated mouse models 네이버 미소장
30 Repaglinide, but Not Nateglinide Administered Supraspinally and Spinally Exerts an Anti-Diabetic Action in D-Glucose Fed and Streptozotocin-Treated Mouse Models 소장
31 Ghrelin administered spinally increases the blood glucose level in mice 네이버 미소장
32 Pertussis toxin administered spinally induces a hypoglycemic effect on normal and diabetic mice. 네이버 미소장
33 Effects of islet-activating protein (IAP) on blood glucose and plasma insulin in healthy volunteers (phase 1 studies). 네이버 미소장
34 Chronic ritodrine treatment induces refractoriness of glucose-lowering b2 adrenoceptor signal in female mice 네이버 미소장
35 β2-Adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: Antagonism by vitamin D3 and curcumin 네이버 미소장

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