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Novel hydrogel composed of both chondroitin sulfate (CS) and gelatin was developed for better cellular interaction through two step double crosslinking of N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride (EDC) chemistries and then click chemistry. EDC chemistry was proceeded during grafting of amino acid dihydrazide (ADH) to carboxylic groups in CS and gelatin network in separate reactions, thus obtaining CS–ADH and gelatin–ADH, respectively.

CS–acrylate and gelatin–TCEP was obtained through a second EDC chemistry of the unreacted free amines of CS–ADH and gelatin–ADH with acrylic acid and tri(carboxyethyl)phosphine (TCEP), respectively. In situ CS–gelatin hydrogel was obtained via click chemistry by simple mixing of aqueous solutions of both CS–acrylate and gelatin–TCEP. ATR-FTIR spectroscopy showed formation of the new chemical bonds between CS and gelatin in CS–gelatin hydrogel network. SEM demonstrated microporous structure of the hydrogel. Within serial precursor concentrations of the CS–gelatin hydrogels studied, they showed trends of the reaction rates of gelation, where the higher concentration, the quicker the gelation occurred. In vitro studies, including assessment of cell viability (live and dead assay), cytotoxicity, biocompatibility via direct contacts of the hydrogels with cells, as well as measurement of inflammatory responses, showed their excellent biocompatibility. Eventually, the test results verified a promising potency for further application of CS–gelatin hydrogel in many biomedical fields, including drug delivery and tissue engineering by mimicking extracellular matrix components of tissues such as collagen and CS in cartilage.

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기사명 저자명 페이지 원문 목차
Oral Immunization of FMDV Vaccine Using pH-Sensitive and Mucoadhesive Thiolated Cellulose Acetate Phthalate Microparticles Ho-Bin Lee, So-Yeon Yoon, Bijay Singh, Seo-Ho Oh, Lianhua Cui, Changguo Yan, Sang-Kee Kang, Yun-Jaie Choi, Chong-Su Cho pp.1-11
Synergistic Effect of Cold Plasma Treatment and RGD Peptide Coating on Cell Proliferation over Titanium Surfaces Ozan Karaman, Seyfi Kelebek, Emine Afra Demirci, Fatma İbiş, Murat Ulu, Utku Kürşat Ercan pp.13-24
Synthesis and Biocompatibility Characterizations of in Situ Chondroitin Sulfate-Gelatin Hydrogel for Tissue Engineering Sumi Bang, Ui-Won Jung, Insup Noh pp.25-35

Non-contact Coculture Reveals a Comprehensive Response of Chondrocytes Induced by Mesenchymal Stem Cells Through Trophic Secretion Lei Xu, Yuxi Wu, Yanli Liu, Yan Zhou, Zhaoyang Ye, Wen-Song Tan pp.37-48
Adipose Stem Cells with Conditioned Media for Treatment of Acne Vulgaris Scar Xing Shan, Jong Hyeon Choi, Ki Joo Kim, Yoon Jae Lee, Yeon Hee Ryu, Su Jin Lee, Suk-Ho Moon, Jong Won Rhie pp.49-61

Substance-P Ameliorates Dextran Sodium Sulfate-Induced Intestinal Damage by Preserving Tissue Barrier Function Dae Yeon Hwang, Suna Kim, Hyun Sook Hong pp.63-73
Mesenchymal Stromal Cells from the Maternal Segment of Human Umbilical Cord is Ideal for Bone Regeneration in Allogenic Setting Jezamine Lim, Zainul Rashid Mohamad Razi, Jia Xian Law, Azmawati Mohammed Nawi, Ruszymah Binti Haji Idrus, Tan Geok Chin, Muaatamarulain Mustangin, Min Hwei Ng pp.75-87
Implantation of Bone Marrow Stromal Cell Sheets Derived from Old Donors Supports Bone Tissue Formation Manabu Akahane, Takamasa Shimizu, Yusuke Inagaki, Tsutomu Kira, Takuya Egawa, Akinori Okuda, Tadanobu Onishi, Tomoaki Imamura, Yasuhito Tanaka pp.89-100
Osteochondral Regeneration with a Scaffold-Free Three-Dimensional Construct of Adipose Tissue-Derived Mesenchymal Stromal Cells in Pigs Daiki Murata, Shizuka Akieda, Kazuhiro Misumi, Koichi Nakayama pp.101-113
Different Bone Healing Effects of Undifferentiated and Osteogenic Differentiated Mesenchymal Stromal Cell Sheets in Canine Radial Fracture Model Yongseok Yoon, Imdad Ullah Khan, Kyeong Uk Choi, Taeseong Jung, Kwangrae Jo, Su-Hyung Lee, Wan Hee Kim, Dae-Yong Kim, Oh-Kyeong Kweon pp.115-124

참고문헌 (38건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Tissue Engineering of Articular Cartilage : From Bench to Bed-side 소장
2 Biomimetic microenvironments for regenerative endodontics. 소장
3 Electrophoretically prepared hybrid materials for biopolymer hydrogel and layered ceramic nanoparticles. 소장
4 Slow-release RGD-peptide hydrogel monoliths. 네이버 미소장
5 Bang S, Das D, Yu J, Noh I. Evaluation of MC3T3 cells proliferation and drug release study from sodium hyaluronate-BDDGE patterned gel. Nanomaterials (Basel). 2017;7:E328. 미소장
6 Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials 네이버 미소장
7 Novel Hydrogels via Click Chemistry:  Synthesis and Potential Biomedical Applications 네이버 미소장
8 Temperature-triggered enzyme immobilization and release based on cross-linked gelatin nanoparticles. 네이버 미소장
9 Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review. 소장
10 Design properties of hydrogel tissue-engineering scaffolds. 네이버 미소장
11 Characterization of chondroitin sulfate and its interpenetrating polymer network hydrogels for sustained-drug release 네이버 미소장
12 Martel-Pelletier J, Kwan Tat S, Pelletier JP. Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review. Osteoarthritis Cartilage. 2010;18:S7-11. 미소장
13 Chondroitin sulfate promotes activation of cathepsin K. 네이버 미소장
14 Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses. 네이버 미소장
15 Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration: A review 네이버 미소장
16 The Effect of Chondroitin Sulphate and Hyaluronic Acid on Chondrocytes Cultured within a Fibrin-Alginate Hydrogel 네이버 미소장
17 Increasing mechanical strength of gelatin hydrogels by divalent metal ion removal. 네이버 미소장
18 Photocrosslinking of gelatin macromers to synthesize porous hydrogels that promote valvular interstitial cell function. 네이버 미소장
19 Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. 네이버 미소장
20 Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factor 네이버 미소장
21 Gelatin Scaffolds with Controlled Pore Structure and Mechanical Property for Cartilage Tissue Engineering. 네이버 미소장
22 Local administration of low-dose simvastatin-conjugated gelatin hydrogel for tendon-bone healing in anterior cruciate ligament reconstruction. 네이버 미소장
23 Chondroitin sulfate-based biomaterials for tissue engineering 네이버 미소장
24 Synthesis of in situ chondroitin sulfate hydrogel through phosphine-mediated Michael type addition reaction 소장
25 Multiphoton imaging of myogenic differentiation in gelatin-based hydrogels as tissue engineering scaffolds. 소장
26 Synthesis and characterization of chondroitin sulfate–methacrylate hydrogels 네이버 미소장
27 Induction and biological evaluations of self cross-linking chondroitin sulfate-poly(ethylene oxide) hydrogel 소장
28 Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores. 소장
29 Synthesis and in vitro characterizations of porous carboxymethyl cellulose-poly(ethylene oxide) hydrogel film. 소장
30 Development and physicochemical evaluation of chondroitin sulfate-poly(ethylene oxide) hydrogel 소장
31 In situ crosslinkable hyaluronan hydrogels for tissue engineering 네이버 미소장
32 Electrospun Fibrous Silk Fibroin/Poly(L-Lactic Acid) Scaffold for Cartilage Tissue Engineering 소장
33 In Vitro Performance of Injectable Chitosan-Tripolyphosphate Scaffolds Combined with Platelet-Rich Plasma 소장
34 Bone Morphogenetic Protein-2 Sustained Delivery by Hydrogels with Microspheres Repairs Rabbit Mandibular Defects 소장
35 Nanofibrous scaffolds in biomedical applications 네이버 미소장
36 Investigation of the changes of biophysical/mechanical characteristics of differentiating preosteoblasts in vitro. 소장
37 Anti-inflammatory activity of chondroitin sulfate 네이버 미소장
38 Silk fibroin/hydroxyapatite composite hydrogel induced by gamma-ray irradiation for bone tissue engineering. 소장

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