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Purpose: To evaluate the therapeutic effect of human embryonic stem cell (hESC)-derived multipotent mesenchymal stem cells (M-MSCs) on ketamine-induced cystitis (KC) in rats.

Methods: To induce KC, 10-week-old female rats were injected with 25-mg/kg ketamine hydrochloride twice weekly for 12 weeks. In the sham group, phosphate buffered saline (PBS) was injected instead of ketamine. One week after the final injection of ketamine, the indicated doses (0.25, 0.5, and 1×10⁶ cells) of M-MSCs (KC+M-MSC group) or PBS vehicle (KC group) were directly injected into the bladder wall. One week after M-MSC injection, the therapeutic outcomes were evaluated via cystometry, histological analyses, and measurement of gene expression. Next, we compared the efficacy of M-MSCs at a low dose (1×10⁵ cells) to that of an identical dose of adult bone marrow (BM)-derived MSCs.

Results: Rats in the KC group exhibited increased voiding frequency and reduced bladder capacity compared to rats of the sham group. However, these parameters recovered after transplantation of M-MSCs at all doses tested. KC bladders exhibited markedly increased mast cell infiltration, apoptosis, and tissue fibrosis. Administration of M-MSCs significantly reversed these characteristic histological alterations. Gene expression analyses indicated that several genes associated with tissue fibrosis were markedly upregulated in KC bladders. However the expression of these genes was significantly suppressed by the administration of M-MSCs. Importantly, M-MSCs ameliorated bladder deterioration in KC rats after injection of a low dose (1×10⁵) of cells, at which point BM-derived MSCs did not substantially improve bladder function.

Conclusions: This study demonstrates for the first time the therapeutic efficacy of hESC-derived M-MSCs on KC in rats. MMSCs restored bladder function more effectively than did BM-derived MSCs, protecting against abnormal changes including mast cell infiltration, apoptosis and fibrotic damage.

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기사명 저자명 페이지 원문 목차
Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome Lori Birder, Karl-Erik Andersson pp.3-9

Laparoscopic Approach for Intravesical Surgery Using Pneumovesicum in Urology : Literature Review Bum Sik Tae, Hoon Choi, Jae Young Park, Jae Hyun Bae pp.10-22

Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits Verónica García-Villamar, Laura G. Hernández-Aragón, Jesús R. Chávez-Ríos, Arturo Ortega, Margarita Martínez-Gómez , Francisco Castelán pp.23-33

The Therapeutic Effect of Human Embryonic Stem Cell-Derived Multipotent Mesenchymal Stem Cells on Chemical-Induced Cystitis in Rats Sang Wook Lee, Chae-Min Ryu, Jung-Hyun Shin, Daeheon Choi, Aram Kim, Hwan Yeul Yu, Ju-Young Han , Hye-Yeon Lee, Jisun Lim, Yong Hwan Kim, Jinbeom Heo, Seungun Lee, Hyein Ju, Sujin Kim, Ki-Sung Hong , Ji-Yeon Han, Miho Song, Hyung-Min Chung, Jun Ki Kim, Dong-Myung Shin, Myung-Soo Choo pp.34-45

Urothelial Dysfunction and Chronic Inflammation are Associated With Increased Bladder Sensation in Patients With Chronic Renal Insufficiency Sheng-Fu Cheng, Yuan-Hong Jiang, Hann-Chorng Kuo pp.46-54

Differences in Urodynamic Parameters According to the Presence of a Hunner Lesion in Women With Interstitial Cystitis/Bladder Pain Syndrome Sun Tae Ahn, Hyeong Guk Jeong, Tae Yong Park, Jong Wook Kim, Hong Seok Park, Du Geon Moon, Jeong Gu Lee, Mi Mi Oh pp.55-61

참고문헌 (37건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Ketamine: an update on its abuse. 네이버 미소장
2 THE PREVALENCE AND NATURAL HISTORY OF URINARY SYMPTOMS AMONG RECREATIONAL KETAMINE USERS 네이버 미소장
3 Patient characteristics for different therapeutic strategies in the management ketamine cystitis 네이버 미소장
4 Chen IC, Lee MH, Chen WC, Hu TC, Lin HY. Risk factors of lower urinary tract syndrome among ketamine users. Low Urin Tract Symptoms 2017 Jul 13 [Epub]. https://doi.org/10.1111/luts.12178. 미소장
5 Possible pathophysiology of ketamine‐related cystitis and associated treatment strategies 네이버 미소장
6 The destruction of the lower urinary tract by ketamine abuse: a new syndrome? 네이버 미소장
7 Ketamine-associated urinary tract dysfunction: an underrecognized clinical entity. 네이버 미소장
8 Jiang S, Xie K, Cai YB. Treatment ketamine-related bladder dysfunction by intravesical injection of botulinum toxin A. J Third Mil Med Univ 2012;34:1120-2. 미소장
9 Augmentation enterocystoplasty is effective in relieving refractory ketamine‐related bladder pain 네이버 미소장
10 Regenerative Therapy and Immune Modulation Using Umbilical Cord Blood–Derived Cells 네이버 미소장
11 Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis. 네이버 미소장
12 Periurethral Injection of Autologous Adipose-Derived Stem Cells with Controlled-Release Nerve Growth Factor for the Treatment of Stress Urinary Incontinence in a Rat Model 네이버 미소장
13 Regenerative medicine in urology 네이버 미소장
14 Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy 네이버 미소장
15 Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitis by Activating Wnt Signaling Pathway. 네이버 미소장
16 Mesenchymal stem cells protect against the tissue fibrosis of ketamine-induced cystitis in rat bladder. 네이버 미소장
17 Evaluation of the incidence and risk factors associated with persistent frequency in interstitial cystitis/bladder pain syndrome and the efficacy of antimuscarinic treatment. 소장
18 Umbilical cord blood: a trustworthy source of multipotent stem cells for regenerative medicine. 네이버 미소장
19 Concise Review: The Immune Status of Mesenchymal Stem Cells and Its Relevance for Therapeutic Application 네이버 미소장
20 Human embryonic stem cell-derived mesenchymal progenitors--potential in regenerative medicine. 네이버 미소장
21 Embryonic Stem Cell Lines Derived from Human Blastocysts 네이버 미소장
22 Differentiation of hESCs into Mesodermal Subtypes: Vascular-, Hematopoietic- and Mesenchymal-lineage Cells. 소장
23 Perivascular Progenitor Cells Derived From Human Embryonic Stem Cells Exhibit Functional Characteristics of Pericytes and Improve the Retinal Vasculature in a Rodent Model of Diabetic Retinopathy 네이버 미소장
24 A porous membrane-mediated isolation of mesenchymal stem cells from human embryonic stem cells. 네이버 미소장
25 The Role of Intra-abdominal Pressure Measurement in Awake Rat Cystometry. 소장
26 Urodynamic Findings in an Awake Chemical Cystitis Rat Model Observed by Simultaneous Registrations of Intravesical and Intraabdominal Pressures 네이버 미소장
27 Jin HJ, Lee HJ, Heo J, Lim J, Kim M, Kim MK, et al. Senescence-associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells. Antioxid Redox Signal 2016;24:471-85. 미소장
28 Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l 네이버 미소장
29 Jeong EM, Yoon JH, Lim J, Shin JW, Cho AY, Heo J, et al. Real-time monitoring of glutathione in living cells reveals that high glutathione levels are required to maintain stem cell function. Stem Cell Reports 2018 Jan 3 [Epub]. pii: S2213-6711(17)30555-6. https://doi.org/10.1016/j.stemcr.2017.12.007. 미소장
30 The fibrosis of ketamine, a noncompetitive N-methyl-d-aspartic acid receptor antagonist dose-dependent change in a ketamine-induced cystitis rat model. 네이버 미소장
31 Biological effect of ketamine in urothelial cell lines and global gene expression analysis in the bladders of ketamine‑injected mice. 네이버 미소장
32 Effects of long‐term ketamine administration on rat bladder protein levels: A proteomic investigation using two‐dimensional difference gel electrophoresis system 네이버 미소장
33 Intact urothelial barrier function in a mouse model of ketamine-induced voiding dysfunction. 네이버 미소장
34 Improved efficacy andcellular properties of human embryonic stem cell derivative in a preclinical model of bladder pain syndrome 네이버 미소장
35 Chronic Pelvic Pain as a Form of Complex Regional Pain Syndrome 네이버 미소장
36 Rosen JM, Klumpp DJ. Mechanisms of pain from urinary tract infection. Int J Urol 2014;21 Suppl 1:26-32. 미소장
37 Tests and models of nociception and pain in rodents 네이버 미소장

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