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Background: MicroRNAs (miRNAs) are short, non-coding RNAs that mediate post-transcriptional gene regulation. They are commonly deregulated in human malignancies, including non-small cell lung cancer (NSCLC). The aim of this study is to investigate miRNA expression in T790M-mutated NSCLC resistant to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Methods: Six cases of resected NSCLC harboring the T790M mutation were examined. We performed miRNA time polymerase chain reaction (PCR) array profiling using EGFR T790M-mutated NSCLC and L858R-mutated NSCLC. Once identified, miRNAs that were differentially expressed between the two groups were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Results: miRNA PCR array profiling revealed three up-regulated miRNAs whose expression levels were altered 4.0-fold or more in the EGFR T790M mutation group than in the L858R group: miR-1 (fold change, 4.384), miR-196a (fold change, 4.138), and miR-124 (fold change, 4.132). The three differentially expressed miRNAs were validated by qRT-PCR, and they were found to be overexpressed in the T790M group relative to L858R group. In particular, expression levels of miR-1 and miR-124 were significantly higher in the T790M group (p-value of miR-1 = .004, miR-124 = .007, miR-196a = .096). Conclusions: MiR-1, miR-124, and miR-196a are overexpressed in EGFR T790M mutated NSCLC.

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기사명 저자명 페이지 원문 목차
Abrupt Dyskeratotic and Squamoid Cells in Poorly Differentiated Carcinoma : Case Study of Two Thoracic NUT Midline Carcinomas with Cytohistologic Correlation Taebum Lee, Sangjoon Choi, Joungho Han, Yoon-La Choi, Kyungjong Lee p.349-353

An Immunohistochemical and Polarizing Microscopic Study of the Tumor Microenvironment in Varying Grades of Oral Squamous Cell Carcinoma Aeman Khalid, Safia Siddiqui, Bharadwaj Bordoloi, Nafis Faizi, Fahad Samadi, Noora Saeed p.314-322

Bile Granuloma Mimicking Peritoneal Seeding : A Case Report Hasong Jeong, Hye Won Lee, Hye Ra Jung, Ilseon Hwang, Sun Young Kwon, Yu Na Kang, Sang Pyo Kim, Misun Choe p.339-343

C-reactive Protein Overexpression in the Background Liver of Hepatitis B Virus-Associated Hepatocellular Carcinoma Is a Prognostic Biomarker Jin Ho Shin, Eunsil Yu, Eun Na Kim, Chong Jai Kim p.267-274

Chronic Placental Inflammation as a Risk Factor of Severe Retinopathy of Prematurity Chae Young Kim, Euiseok Jung, Eun Na Kim, Chong Jai Kim, Joo Yong Lee, Ji Hye Hwang, Woo Sun Song, Byong Sop Lee, Ellen Ai-Rhan Kim, Ki-Soo Kim p.290-297

Differential MicroRNA Expression between EGFR T790M and L858R Mutated Lung Cancer Ji Yeon Kim, Woo Jeong Lee, Ha Young Park, Ahrong Kim, Dong Hoon Shin, Chang Hun Lee p.275-282

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars Mi Young Lee, Eun Shin, Hyunchul Kim, In Suk Kwak, Younghee Choi p.307-313

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman : A Case Report and Literature Review Nu Ri Jang, Dae Hyung Lee, Eun Jung Jang, Young Kyung Bae, Jina Baek, Min Hye Jang p.344-348

Prognostic Role of Metastatic Lymph Node Ratio in Papillary Thyroid Carcinoma Jung-Soo Pyo, Jin Hee Sohn, Kyungseek Chang p.331-338

Prognostic Significance of EPHB2 Expression in Colorectal Cancer Progression Bo Gun Jang, Hye Sung Kim, Weon Young Chang, Jeong Mo Bae, Gyeong Hoon Kang p.298-306

Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma Jae Won Joung, Hoon Kyu Oh, Sun Jae Lee, Young Ah Kim, Hyun Jin Jung p.323-330

p40 Immunohistochemistry Is an Excellent Marker in Primary Lung Squamous Cell Carcinoma Khairunisa Ahmad Affandi, Nur Maya Sabrina Tizen, Muaatamarulain Mustangin, Reena Rahayu Md Zin p.283-289

참고문헌 (44건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Cancer treatment and survivorship statistics, 2016 네이버 미소장
2 Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. 네이버 미소장
3 EGFR T790M resistance mutation in non small-cell lung carcinoma 네이버 미소장
4 Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. 네이버 미소장
5 Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer: A new era begins 네이버 미소장
6 MicroRNA expression and function in cancer. 네이버 미소장
7 MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. 네이버 미소장
8 Plasma MiR-21: A Potential Diagnostic Marker of Colorectal Cancer 네이버 미소장
9 Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. 네이버 미소장
10 microRNA expression profile in a large series of bladder tumors: Identification of a 3‐miRNA signature associated with aggressiveness of muscle‐invasive bladder cancer 네이버 미소장
11 Up-regulation ofis a potent prognostic marker for lung adenocarcinoma of female non-smokers 네이버 미소장
12 Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation 네이버 미소장
13 miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124 네이버 미소장
14 Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. 네이버 미소장
15 Betel D, Wilson M, Gabow A, Marks DS, Sander C. The microRNA. org resource: targets and expression. Nucleic Acids Res 2008; 36: D149-53. 미소장
16 Gene Set Enrichment Analysis: A Knowledge-Based Approach for Interpreting Genome-Wide Expression Profiles 네이버 미소장
17 First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. 네이버 미소장
18 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. 네이버 미소장
19 Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation. 네이버 미소장
20 The T790M Mutation in EGFR Kinase Causes Drug Resistance by Increasing the Affinity for ATP 네이버 미소장
21 The quest to overcome resistance to EGFR-targeted therapies in cancer. 네이버 미소장
22 Acquired resistance to TKIs in solid tumours: learning from lung cancer. 네이버 미소장
23 Osimertinib in Pretreated T790M-Positive Advanced Non-Small-Cell Lung Cancer: AURA Study Phase II Extension Component. 네이버 미소장
24 Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer. 네이버 미소장
25 microRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers. 네이버 미소장
26 MiR-1 downregulation correlates with poor survival in clear cell renal cell carcinoma where it interferes with cell cycle regulation and metastasis. 네이버 미소장
27 Role of MicroRNA-1 in Human Cancer and Its Therapeutic Potentials 네이버 미소장
28 miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1. 네이버 미소장
29 miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. 네이버 미소장
30 Decreased expression of microRNA-124 is an independent unfavorable prognostic factor for patients with breast cancer 네이버 미소장
31 Clinical Likelihood of Sporadic Primary EGFR T790M Mutation in EGFR-Mutant Lung Cancer 네이버 미소장
32 Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. 네이버 미소장
33 Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: Comparison between T790M mutation-positive and mutation-negative populations. 네이버 미소장
34 EGFR compound mutants and survival on erlotinib in non-small cell lung cancer (NSCLC) patients (p) in the EURTAC study. 네이버 미소장
35 Highly Sensitive Detection of EGFR T790M Mutation Using Colony Hybridization Predicts Favorable Prognosis of Patients with Lung Cancer Harboring Activating EGFR Mutation 네이버 미소장
36 MicroRNA Expression Aids the Preoperative Diagnosis of Pancreatic Ductal Adenocarcinoma 네이버 미소장
37 Clinical Potential of MicroRNAs in Pancreatic Ductal Adenocarcinoma 네이버 미소장
38 MicroRNA‐196: critical roles and clinical applications in development and cancer 네이버 미소장
39 Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation. 네이버 미소장
40 Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. 네이버 미소장
41 Up-regulation of miR-124 inhibits invasion and proliferation of prostate cancer cells through mediating JAK-STAT3 signaling pathway. 네이버 미소장
42 MiR-124 inhibits the growth of glioblastoma through the downregulation of SOS1. 네이버 미소장
43 Coexistence of EGFR T790M mutation and common activating mutations in pretreatment non-small cell lung cancer: A systematic review and meta-analysis. 네이버 미소장
44 Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. 네이버 미소장

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