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Toxoplasma gondii, a ubiquitous, intracellular parasite of the phylum Apicomplexa, infects an estimated one-third of the human population as well as a broad range of warm-blooded animals. We have observed that some tyrosine kinase inhibitors suppressed the growth of T. gondii within host ARPE-10 cells. Among them, afatinib, human epithermal growth factor receptor 2 and 4 (HER2/4) inhibitor, may be used as a therapeutic agent for inhibiting parasite growth with minimal adverse effects on host. In this report, we conducted a proteomic analysis to observe changes in host proteins that were altered via infection with T. gondii and the treatment of HER2/4 inhibitors. Secreting proteins were subjected to a procedure of micor basic reverse phase liquid chromatography, nano-liquid chromatography-mass spectrometry, and ingenuity pathway analysis serially. As a result, the expression level of heterogeneous nuclear ribonucleoprotein K, semaphorin 7A, a GPI membrane anchor, serine/threonine-protein phosphatase 2A, and calpain small subunit 1 proteins were significantly changed, and which were confirmed further by western blot analysis. Changes in various proteins, including these 4 proteins, can be used as a basis for explaining the effects of T. gondii infections and HER2/4 inhibitors.

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Cutaneous leishmaniasis situation and predicting the distribution of Phlebotomus papatasi and P. sergenti as vectors of leishmaniasis in Ardabil Province, Iran Ali Khamesipour, Soheila Molaei, Navid Babaei-Pouya, Eslam Moradi-Asl p. 229-236

Polarization of M2 macrophages by interaction between prostate cancer cells treated with Trichomonas vaginalis and adipocytes Hyo-Yeoung Chung, Jung-Hyun Kim, Ik-Hwan Han, Jae-Sook Ryu p. 217-227

The role of PI3K/AKT pathway and NADPH oxidase 4 in host ROS manipulation by Toxoplasma gondii Hei Gwon Choi, Fei-Fei Gao, Wei Zhou, Pu-Reum Sun, Jae-Min Yuk, Young-Ha Lee, Guang-Ho Cha p. 237-247

Secretome analysis of host cells infected with Toxoplasma gondii after treatment of human epidermal growth factor receptor 2/4 inhibitors Hye-Jung Kim, Hye-Jin Ahn, Hyeweon Kang, Jaehui Park, Seul Gi Oh, Saehae Choi, Won-Kyu Lee, Ho-Woo Nam p. 249-255

Spatiotemporal trends of malaria in relation to economic development and cross-border movement along the China–Myanmar border in Yunnan Province Xiaotao Zhao, Weerapong Thanapongtharm, Siam Lawawirojwong, Chun Wei, Yerong Tang, Yaowu Zhou, Xiaodong Sun, Jestumon Sattabongkot, Jaranit Kaewkungwal p. 267-278

Descriptions of two digenean trematodes found from a Chinese sea snake, Laticauda semifasciata, in Republic of Korea Seongjun Choe, Il-Hun Kim, Min-Seop Kim, Hae Rim Lee, Youngjun Kim, Keeseon S. Eom p. 279-285

A retrieved sparganum of Spirometra erinaceieuropaei from a Korean man during mechanical thrombectomy Yang-Ha Hwang, Wonsoo Son, Yong-Won Kim, Dong-Hun Kang, Hyun-Ha Chang, Youn-Kyoung Goo, Yeonchul Hong, Dong-Il Chung p. 309-313

Molecular detection of Toxoplasma gondii in Haemaphysalis ticks in Korea Ju Yeong Kim, You Shine Kwak, In-Yong Lee, Tai-Soon Yong p. 327-331, [1-2]

Molecular detection and subtyping of human Blastocystis and the clinical implications : comparisons between diarrheal and non-diarrheal groups in Korean populations Moon-Ju Kim, Eun Jeong Won, Soo Hyun Kim, Jong Hee Shin, Jong-Yil Chai p. 321-326

Transcriptomic features of Echinococcus granulosus protoscolex during the encystation process Junjie Fan, Hongye Wu, Kai Li, Xunuo Liu, Qingqing Tan, Wenqiao Cao, Bo Liang, Bin Ye p. 287-299, [1-4]

First infestation case of sarcoptic mange from a pet rabbit Oryctolagus cuniculus in Republic of Korea Seongjun Choe, Sungryong Kim, Ki-Jeong Na, Tilak Chandra Nath, Barakaeli Abdieli Ndosi, Yeseul Kang, Mohammed Mebarek Bia, Dongmin Lee, Hansol Park, Chatanun Eamudomkarn, Hyeong-Kyu Jeon, Keeseon S. Eom p. 315-319

Seroprevalence and B1 gene phylogeny of Toxoplasma gondii of dogs and cats in Republic of Korea Yeojin Park, Jinhyeong Noh, Hyun-Ji Seo, Keun-Ho Kim, Subin Min, Mi-Sun Yoo, Bo-Ram Yun, Jong-Ho Kim, Eun-Jin Choi, Doo-Sung Cheon, Sung-Jong Hong, Soon-Seek Yoon, Yun Sang Cho p. 257-265

High prevalence of Clonorchis sinensis and other zoonotic trematode metacercariae in fish from a local market in Yen Bai Province, Northern Vietnam Fuhong Dai, Sung-Jong Hong, Jhang Ho Pak, Thanh Hoa Le, Seung-Ho Choi, Byoung-Kuk Na, Woon-Mok Sohn p. 333-338

Surveillance of chigger mite vectors for Tsutsugamushi disease in the Hwaseong area, Gyeonggi-do, Republic of Korea, 2015 Young Yil Bahk, Hojong Jun, Seo Hye Park, Haneul Jung, Seung Jegal, Myung-Deok Kim-Jeon, Jong Yul Roh, Wook-Gyo Lee, Seong Kyu Ahn, Jinyoung Lee, Kwangsig Joo, Young Woo Gong, Mun Ju Kwon, Tong-Soo Kim p. 301-308, [1-2]

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