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Contents

Melanogenesis promotion by 3-deazaneplanocin A, a specific inhibitor of S-adenosylhomocysteine hydrolase, in B16/F10 melanoma cells ＝ B16/F10 흑색종 세포에서 S-Adenosylhomocysteine Hydrolase의 선택적 저해제 3-Deazaneplanocin A에 의한 멜라닌 생성 증진 / Yun Jeong Hwang ; Yong Chool Boo 1

요약 1

Abstract 1

1. Introduction 2

2. Materials and Methods 2

2.1. An Epigenetic Screening Library 2

2.2. Reagents 4

2.3. Cell Culture 4

2.4. Screening Assay for Melanin Synthesis 5

2.5. Cell Viability Assay 5

2.6. Melanin and Protein Content Assays 5

2.7. Cellular TYR Activity Assay 5

2.8. Western Blot Analysis 5

2.9. Quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) Analysis 6

2.10. Enzyme-linked Immunosorbent Assay (ELISA) for S-adenosylhomocysteine 6

2.11. Statistical Analysis 7

3. Results 7

3.1. Screening Assays 7

3.2. Comparison of Three Selected Drugs 8

3.3. Effects of DZNep on Cell Viability and Intracellular Melanin Content 8

3.4. Effects of DZNep on Cellular TYR Activity 9

3.5. Effects of DZNep on the Protein Levels of Melanogenic Enzymes 9

3.6. Effects of DZNep on the mRNA Levels of Melanogenic Enzymes 10

3.7. Effects of DZNep on MITF Protein and mRNA Levels 10

3.8. Effects of DZNep on the Content of S-Adenosylhomocysteine 11

4. Discussion 11

5. Conclusion 13

References 13

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기사명 저자명 페이지 원문 목차
라벤더 꽃과 에센셜 오일의 향기 성분 분석 및 재현 = Analysis and reproduction of fragrance components of Lavandula angustifolia flower and essential oil 고은성, 김형묵, 곽병문, 이미기, 빈범호 p. 93-98

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돌외 캘러스 추출물의 항염, 항알러지 및 S. aureus 에 의한 각질세포 손상 완화 효능 = Effects of Gynostemma pentaphyllum callus extract on anti-inflammation, anti-allergy, and alleviation of keratinocyte damage caused by S. aureus 이혜숙, 이혜민, 김한영 p. 99-105

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Melanogenesis promotion by 3-deazaneplanocin A, a specific inhibitor of S-adenosylhomocysteine hydrolase, in B16/F10 melanoma cells = B16/F10 흑색종 세포에서 S-Adenosylhomocysteine Hydrolase의 선택적 저해제 3-Deazaneplanocin A 에 의한 멜라닌 생성 증진 Yun Jeong Hwang, Yong Chool Boo p. 107-121

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흑효모를 이용한 참도박 발효 추출물의 항염 효과 = Anti-inflammatory effects of Grateloupia elliptica fermenting extracts using Aureobasidium pullulans 부반빈, 이경은, 강상구 p. 123-131

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나이아신아마이드의 인공피부조직 투과 개선을 위한 고형지질나노입자의 설계 연구 = Design of solid lipid nanoparticles to improve penetration of niacinamide through artificial skin tissue 여수호 p. 133-138

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사과 캘러스로부터 분리된 엑소좀-유사 Nanovesicles의 피부 장벽 및 피부 노화 방지 개선 연구 = Study on reinforcing skin barrier and anti-aging of exosome-like nanovesicles isolated from Malus domestica fruit callus 서유리, 이광수, 강용원 p. 139-145

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(The) effect of low molecule collagen peptide on skin anti-glycation and collagen synthesis as a skin aging therapy = 피부 노화 치료로서 저분자콜라겐펩타이드의 피부 항당화와 콜라겐 합성 효과 Hong Seok Kim, Won Kyu Hong, Mun Hoe Lee, Hyeong Min Kim, Hee Chul Chung, Jin Hee Lee p. 147-153

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피부 병원성균에 대한 오배자 천연 복합물의 시너지 항균 효과 = Antimicrobial synergistic effects of gallnut extract and natural product mixture against human skin pathogens 김주희, 최연선, 김왕배, 박진오, 임동중 p. 155-161

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물성 분석을 통한 Valine의 여드름균 바이오필름 내부 세균막 형성 억제 연구 = A study on inhibition of bacterial membrane formation in biofilm formed by acne bacteria in valine through property analysis 송상훈, 황병우, 손성길, 강내규 p. 163-170

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유산균 유래 엑소좀 유사 나노베지클의 피부 장벽 개선 효과 = Skin barrier improvement effect of exosomal nanovesicles derived from lactic acid bacteria 왕혜수, 이광수, 강용원 p. 171-178

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Serine의 인공피부조직 투과 개선을 위한 Stearic Acid 기반 고형지질나노입자의 설계 연구 = A study on the design of stearic acid-based solid lipid nanoparticles for the improvement of artificial skin tissue transmittance of serine 여수호 p. 179-184

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참고문헌 (49건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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12 Y. C. Boo, Up- or downregulation of melanin synthesis using amino acids, peptides, and their analogs, Biomedicines, 8(9), 322 (2020). 미소장
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14 Y. C. Boo, p-coumaric acid as an active ingredient in cosmetics: a review focusing on its antimelanogenic effects, Antioxidants, 8(8), 275 (2019). 미소장
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18 K. D. Haltaufderhyde and E. Oancea, Genome-wide transcriptome analysis of human epidermal melanocytes, Genomics, 104(6 Pt B), 482 (2014). 미소장
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21 J. S. Shin, H. S. Jeong, M. K. Kim, H. Y. Yun, K. J. Baek, N. S. Kwon, and D. S. Kim, The DNA methylation inhibitor 5-azacytidine decreases melanin synthesis by inhibiting CREB phosphorylation, Pharmazie, 70(10), 646 (2015). 미소장
22 S. Yokoyama, E. Feige, L. L. Poling, C. Levy, H. R. Widlund, M. Khaled, A. L. Kung, and D. E. Fisher, Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage, Pigment Cell Melanoma Res., 21(4), 457 (2008). 미소장
23 K. H. Kim, B. H. Bin, J. Kim, S. E. Dong, P. J. Park, H. Choi, B. J. Kim, S. J. Yu, H. Kang, H. H. Kang, E. G. Cho, and T. R. Lee, Novel inhibitory function of miR-125b in melanogenesis, Pigment Cell Melanoma Res., 27(1), 140 (2014). 미소장
24 K. H. Kim, T. R. Lee, and E. G. Cho, SH3BP4, a novel pigmentation gene, is inversely regulated by miR-125b and MITF, Exp. Mol. Med., 49(8), e367 (2017). 미소장
25 H. Song, Y. J . Hwang, J. W. Ha, a nd Y. C. Boo, Screening of an epigenetic drug library identifies 4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-phenyl -benzeneacetamide that reduces melanin synthesis by inhibiting tyrosinase activity independently of epigenetic mechanisms, Int. J. Mol. Sci., 21(13), 4589 (2020). 미소장
26 R. I. Glazer, K. D. Hartman, M. C. Knode, M. M. Richard, P. K. Chiang, C. K. Tseng, and V. E. Marquez, 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60, Biochem. Biophys. Res. Commun., 135(2), 688 (1986). 미소장
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28 J. K. Seok, S. W. Lee, J. Choi, Y. M. Kim, and Y. C. Boo, Identification of novel antimelanogenic hexapeptides via positional scanning of a synthetic peptide combinatorial library, Exp. Dermatol., 26(8), 742 (2017). 미소장
29 J. H. Kim, J. K. Seok, Y. M. Kim, and Y. C. Boo, Identification of small peptides and glycinamide that inhibit melanin synthesis using a positional scanning synthetic peptide combinatorial library, Br. J. Dermatol., 181(1), 128 (2019). 미소장
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32 S. W. Lee, J. H. Kim, H. Song, J. K. Seok, S. S. Hong, and Y. C. Boo, Luteolin 7-sulfate attenuates melanin synthesis through inhibition of CREB- and MITF-mediated tyrosinase expression, Antioxidants, 8(4), 87 (2019). 미소장
33 S. M. An, J. S. Koh, and Y. C. Boo, Inhibition of melanogenesis by tyrosinase siRNA in human melanocytes, BMB Rep., 42(3), 178 (2009). 미소장
34 R. Yang, Y. Zheng, L. Li, S. Liu, M. Burrows, Z. Wei, A. Nace, M. Herlyn, R. Cui, W. Guo, G. Cotsarelis, and X. Xu, Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors, Nat. Commun., 5, 5807 (2014). 미소장
35 G. Y. Seo, Y. Ha, A. H. Park, O. W. Kwon, and Y. J. Kim, Leathesia difformis extract inhibits alpha-MSH-induced melanogenesis in B16F10 cells via down-regulation of CREB signaling pathway, Int. J. Mol. Sci., 20(3), 536 (2019). 미소장
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