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Contents

Synthesis and characterization of dual-sensitive PAMAM derivatives conjugated with enzyme cleavable peptides as gene carriers / Jeil Lee ; Seunghye Park ; Yong-Eun Kwon ; Eugeney Oh ; Dong Woon Kim ; Hwanuk Guim ; Jehyeong Yeon ; Jin-Cheol Kim ; Joon Sig Choi 1

Abstract 1

1. Introduction 1

2. Experimental 2

2.1. Materials 2

2.2. Synthesis of FKFL-cPAMAM G3, RFKFL-cPAMAM G3, and RHFKFL-cPAMAM G3 2

2.3. High-performance liquid chromatography (HPLC) 2

2.4. Plasmid DNA preparation 2

2.5. Agarose gel retardation assay and DNA release test 3

2.6. Dynamic light scattering (DLS) and ζ-potential measurements 3

2.7. Scanning transmission electron microscopy (-in-SEM) imaging and low-voltage energy dispersive X-ray spectroscopy (EDS) 3

2.8. Cell culture 3

2.9. Transfection assay 3

2.10. Cytotoxicity assay 3

2.11. Confocal microscopy 3

2.12. Statistical analysis 4

3. Results and discussion 4

3.1. Synthesis of cPAMAM G3 derivatives conjugated with the cathepsin B-cleavable linker 4

3.2. Characterization of polyplexes and DNA release evaluation 7

3.3. Evaluation of the physicochemical properties of cPAMAM derivatives/pCN-Luci polyplexes 7

3.4. Transfection efficiency in cell lines 9

3.5. Cytotoxicity evaluation of polymer and polyplexes 10

3.6. Intracellular distribution analysis of polyplexes 11

4. Conclusions 12

References 12

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Synthesis and characterization of dual-sensitive PAMAM derivatives conjugated with enzyme cleavable peptides as gene carriers Jeil Lee, Seunghye Park, Yong-Eun Kwon, Eugeney Oh, Dong Woon Kim, Hwanuk Guim, Jehyeong Yeon, Jin-Cheol Kim, Joon Sig Choi p. 636-647

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참고문헌 (28건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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