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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Background/Aims: Tuberculosis has incidence and mortality rates that are among the highest for all communicable diseases. Adverse drug reactions (ADRs) to anti-tubercular drugs are common, and have a major impact on treatment maintenance and prognosis. It is important to understand the characteristics of ADRs and establish a suitable management plan.

Methods: We retrospectively reviewed patients with ADRs during treatment with first-line antitubercular drugs such as isoniazid, rifampicin, ethambutol, and pyrazinamide from 2009 to 2018. Age, sex, and total treatment period, and the onset, severity, seriousness, and system organ class of ADRs, were analyzed to understand the characteristics of first-line anti-tubercular drug-related ADRs.

Results: A total of 1,606 of 5,482 patients (29.3%) experienced ADRs after administration of first-line anti-tubercular drugs. The incidence of ADRs related to isoniazid, rifampicin, ethambutol, and pyrazinamide was 22.2%, 21.3%, 24.5%, and 29.6%, respectively. A total of 2,098 ADR reports were made (mean of 1.3 ± 0.6 per patient). The rates of mild, moderate, and severe ADRs were 32.4%, 61.1%, and 6.5%, respectively. There were 127 reports (6.1%) of serious ADRs. Skin and appendage disorders were most frequently reported (27.5%), followed by gastrointestinal disorders (17.5%), and liver and biliary system disorders (13.1%). The total treatment period was longer in patients who experienced ADRs (224.0 ± 3.1 days vs. 247.0 ± 4.7 days, p = 0.009).

Conclusions: The incidence of ADRs to first-line anti-tuberculosis drugs was 29.3%, and 6.5% were severe ADRS. ADRs prolonged the overall treatment duration, indicating the importance of their detection and management.

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기사명 저자명 페이지 원문 목차
대한의사협회 회장으로서의 포부 : Aspirations as president of the Korean Medical Association : a step for members and nation, to be reborn as a decent and dignified Korean Medical Association / 회원과 국민을 위한 발걸음, 품위 있고 당당한 대한의사협회로 거듭나기 위해 이필수 p. 369-370
다발골수종 및 관련 형질세포 질환의 조기 진단을 위한 선별 검사 = Screening tests for early diagnosis of multiple myeloma and related plasma cell disorders 김진석, 윤성수, 민창기, 이제중, 윤덕현, 김기현 p. 371-381

2021 대한부정맥학회 심방세동 환자의 새로운 접근법 및 통합적 관리 지침 = The 2021 Korean Heart Rhythm Society guidelines for a new approach and integrated management of atrial fibrillation 박준범, 차명진, 백용수, 조민수, 정보영 p. 382-389

약제 감수성 폐결핵의 진단 및 치료의 최신 지견 = Recent advances in drug susceptible pulmonary tuberculosis diagnosis and treatment 류지원, 심태선 p. 390-399

성인 성장호르몬 결핍증의 진단과 치료 = Diagnosis and treatment of adult growth hormone deficiency 김정희 p. 400-407

원발부위불명암의 진단과 치료 = Cancer of unknown primary : diagnosis and treatment 김영생, 이순일 p. 408-414

바이러스 감염 진단을 위한 신속검사 = Rapid tests for the diagnosis of viral infections 김현수 p. 415-420

1차 항결핵제 약물이상반응 현황 : Adverse drug reactions to first-line anti-tubercular drugs based on individual case safety report in a single tertiary hospital / 단일기관 약물이상사례 보고사례 기반 분석 김현화, 문미라, 최나이, 강동윤, 채경옥, 이정실, 임재준, 조상헌, 강혜련 p. 421-431, [1-2]

당뇨병성 케톤산증의 회복 중에 발생한 Torsades de Pointes 유발 심정지 증례 = Cardiac arrest related to torsades de pointes in a patient recovering from diabetic ketoacidosis 김진모, 이주엽, 유원상, 이명용, 정현경 p. 432-437

고혈압 과거력이 없는 여성에서 출산 후 신동맥 파열로 발견된 양측 신동맥 섬유근이형성증 1예 = A rare case of fibromuscular dysplasia with postpartum renal artery rupture in a non-hypertensive woman 김은은, 원유동, 김연희, 신인혜, 김영옥 p. 438-442

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