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Molecular characterization of dysplasia : initiated colorectal cancer with assessing matched tumor and dysplasia samples / Sungwon Jung ; Jong Lyul Lee ; Tae Won Kim ; Jongmin Lee ; Yong Sik Yoon ; Kil Yeon Lee ; Ki-hwan Song ; Chang Sik Yu ; Yong Beom Cho 1

[요약] 1

INTRODUCTION 1

METHODS 2

RESULTS 4

DISCUSSION 8

REFERENCES 9

초록보기

Purpose: Ulcerative colitis (UC) is known to have an association with the increased risk of colorectal cancer (CRC), and UC-associated CRC does not follow the typical progress pattern of adenoma-carcinoma. The aim of this study is to investigate molecular characteristics of UC-associated CRC and further our understanding of the association between UC and CRC.Methods: From 5 patients with UC-associated CRC, matched normal, dysplasia, and tumor specimens were obtained from formalin-fixed paraffin-embedded (FFPE) samples for analysis. Genomic DNA was extracted and whole exome sequencing was conducted to identify somatic variations in dysplasia and tumor samples. Statistical analysis was performed to identify somatic variations with significantly higher frequencies in dysplasia-initiated tumors, and their relevant functions were investigated.Results: Total of 104 tumor mutation genes were identified with higher mutation frequencies in dysplasia-initiated tumors. Four of the 5 dysplasia-initiated tumors (80.0%) have TP53 mutations with frequent stop-gain mutations that were originated from matched dysplasia. APC and KRAS are known to be frequently mutated in general CRC, while none of the 5 patients have APC or KRAS mutation in their dysplasia and tumor samples. Glycoproteins including mucins were also frequently mutated in dysplasia-initiated tumors.Conclusion: UC-associated CRC tumors have distinct mutational characteristics compared to typical adenoma-carcinoma tumors and may have different cancer-driving molecular mechanisms that are initiated from earlier dysplasia status.

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(Editorial) Future direction of enhanced recovery after surgery (ERAS) program in colorectal surgery In Ja Park p. 1-2

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Extended lymphadenectomy in locally advanced rectal cancers : a systematic review Balaji Mahendran, Supriya Balasubramanya, Simone Sebastiani, Sebastian Smolarek p. 3-12

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Long-term evolution of continence and quality of life after sphincteroplasty for obstetric fecal incontinence Vicente Pla-Martí, Jose Martín-Arévalo, Rosa Martí-Fernández, David Moro-Valdezate, Stephanie García-Botello, Alejandro Espí-Macías, Miguel Mínguez-Pérez, Maria Dolores Ruiz-Carmona, Jose Vicente Roig-Vila p. 13-19

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(The) "reverse air leak test" : a new technique for the assessment of low colorectal anastomosis Francesco Crafa, Augusto Striano, Francesco Esposito, Amalia Rosaria Rita Rossetti, Mario Baiamonte, Valeria Gianfreda, Antonio Longo p. 20-27

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Oncological and functional outcomes of transanal total mesorectal excision in a teaching hospital in the Netherlands Joost A.G. van der Heijden, Kelly G.H. van de Pas, Frank J.C. van den Broek, Francois M.H. van Dielen, Gerrit D. Slooter, Adriana J.G. Maaskant-Braat p. 28-35

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(The) impact of variations in care and complications within a colorectal enhanced recovery after surgery program on length of stay James Wei Tatt Toh, Jack Cecire, Kerry Hitos, Karen Shedden, Fiona Gavegan, Nimalan Pathmanathan, Toufic El Khoury, Angelina Di Re, Annelise Cocco, Alex Limmer, Tom Liang, Kar Yin Fok, James Rogers, Edgardo Solis, Grahame Ctercteko p. 36-46

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Clinical validation of implementing enhanced recovery after surgery protocol in elderly colorectal cancer patients Wooree Koh, Chul Seung Lee, Jung Hoon Bae, Abdullah Al-Sawat, In Kyu Lee, Hyeong Yong Jin p. 47-52

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Predictors of postoperative urinary retention after semiclosed hemorrhoidectomy Hong Yoon Jeong, Seok Gyu Song, Jong Kyun Lee p. 53-59

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Proteomic identification of arginine-methylated proteins in colon cancer cells and comparison of messenger RNA expression between colorectal cancer and adjacent normal tissues Yongchul Lim, Da Young Gang, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Hee Cheol Kim p. 60-68

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Foley balloons' tamponade is an effective method for controlling massive pelvic bleeding during colorectal surgery Tzu-Chi Hsu p. 69-71

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Molecular characterization of dysplasia : initiated colorectal cancer with assessing matched tumor and dysplasia samples Sungwon Jung, Jong Lyul Lee, Tae Won Kim, Jongmin Lee, Yong Sik Yoon, Kil Yeon Lee, Ki-hwan Song, Chang Sik Yu, Yong Beom Cho p. 72-81

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Outcomes of surgical management of buschke-lowenstein tumor in a Philippine tertiary hospital Sofia Isabel T. Manlubatan, Mark Augustine S. Onglao, Mayou Martin T. Tampo, Marc Paul J. Lopez p. 82-87

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Single-port robot-assisted abdominoperineal resection : a case review of the first four experiences Moon Suk Choi, Seong Hyeon Yun, Jung Kyong Shin, Yoon Ah Park, Jung Wook Huh, Yong Beom Cho, Hee Cheol Kim, Woo Yong Lee p. 88-92

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(Letter to the Editor) Comments on: factors predicting the presence of concomitant enterocele and rectocele in female patients with external rectal prolapse Ingrid Melo-Amaral, Adrian Teran-Cardoza, Cristopher Varela p. 93-94

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참고문헌 (26건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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20 Benjamin D, Sato T, Cibulskis K, Getz G, Stewart C, Lichtenstein L. Calling somatic SNVs and indels with Mutect2. bioRxiv 2019: 861054. 미소장
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22 D’Aurizio R, Pippucci T, Tattini L, Giusti B, Pellegrini M, Magi A. Enhanced copy number variants detection from whole-exome sequencing data using EXCAVATOR2. Nucleic Acids Res 2016;44: e154. 미소장
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